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EP2082215: MOLECULAR DETECTION SYSTEM
14 Claims, 1 Drawings
The current document has no english abstract.
- A molecular sensor comprising:
a flow path (12) configured for flowing a solution (28) potentially containing a target molecule (26):
a source (16) of polarised light;
a detector (18) arranged to receive light from the source after it has passed through the flow path; and
a sensor element (19) comprising a scaffold moiety (20) with an aspect ratio of at least 75:1 disposed within the flow path and a receptor moiety (24), for the target molecule, attached to the scaffold moiety.
- The molecular sensor of any preceding claim comprising a plurality of scaffold moieties (20).
- The molecular sensor of any preceding claim wherein the or each scaffold moiety (20) has a plurality of receptor moietie (24) attached thereto.
- The molecular sensor of any preceding claim wherein the or each scaffold moiety (20) is anchored in the flow path such that, in use, the or each scaffold moiety is capable of alignment in a flow but its location is fixed within the flow path.
- The molecular sensor of any preceding claim additionally comprising a flow cell which is rotatable in use to generate flow in the solution.
- The molecular sensor of any preceding claim wherein the light source (16) is a source of linearly polarised beams of light.
- The molecular sensor of any preceding claim wherein the light source (16) is a linear dichroic spectroscope.
- The molecular sensor of any preceding claim wherein the detector (18) is one which generates a spectrum that illustrates the absorbance of the solution with respect to wavelength.
- The molecular sensor of any preceding claim wherein the light source (16) and detector (18) are arranged to respectively emit and detect light passing perpendicularly to the flow direction.
- A method for sensing a target molecule (26) in a flowing solution (28) comprising:
providing in a flow path (12) a scaffold moiety (20) with an aspect ratio of at least 75:1 and having a receptor moiety (27), for the target molecule, attached thereto;
flowing a solution (28) potentially containing a target molecule (26) along the flow path (12);
passing polarised light through the flow path; and
detecting the polarised light after it has passed through the flow path.
Foreign Patent Documents
|Document Number||Assignees||Inventors||Issue/Pub Date|
|WO2004010117||UNIVERSITY OF WARWICK|
|RODGER A: "CIRCULAR DICHROISM AND LINEAR DICHROISM" ENCYCLOPEDIA OF ANALYTICAL CHEMISTRY, 2000, pages 10305-10333, XP001153376|
|DAFFORN T R ET AL: "Protein Fiber Linear Dichroism for Structure Determination and Kinetics in a Low-Volume, Low-Wavelength Couette Flow Cell" BIOPHYSICAL JOURNAL, vol. 86, January 2004 (2004-01), pages 404-410, XP002471306 cited in the application|
|SOLIMANI R ET AL: "Flavonoid-DNA Interaction Studied with Flow Linear Dichroism Technique" J. AGRIC. FOOD CHEM., vol. 43, 1995, pages 876-882, XP002471307|
|CHEN R J ET AL: "Noncovalent functionalization of carbon nanotubes for highly specific electronic biosensors" PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC, US, vol. 100, no. 9, 29 April 2003 (2003-04-29), pages 4984-4989, XP002332682 ISSN: 0027-8424|
|DRECHSLER U ET AL: "Nanoparticles: Scaffolds for Molecular Recognition" CHEM. EUR. J., vol. 10, 5 November 2004 (2004-11-05), pages 5570-5579, XP002471308|
|YU C AND IRUDAYARAJ J: "Multiplex Biosensor Using Gold Nanorods" ANALYTICAL CHEMISTRY, vol. 79, no. 2, 15 January 2007 (2007-01-15), pages 572-579, XP002471309|
The current document is not referenced by other documents.