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EP2082215: MOLECULAR DETECTION SYSTEM

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Filing Information

Inventor(s) DAFFORN, TIMOTHY RICHARD, · MATTHEW HICKS ·
Assignee(s) THE UNIVERSITY OF BIRMINGHAM ·
Attorney/Agent(s) David Ian Ward ·
Application Number EP07824622.0
Filing date 11/19/2007
Publication date 07/29/2009
U.S. Classifications --
International Classifications G01N 21/ 19  ·
Kind CodeA1
PCT Application Number GB2007004405 - 11/19/2007
PCT Publication Number WO2008059280 - 05/22/2008
14 Claims, 1 Drawings


Abstract

The current document has no english abstract.

Independent Claims | See all claims (42)

  1. A molecular sensor comprising: a flow path (12) configured for flowing a solution (28) potentially containing a target molecule (26): a source (16) of polarised light; a detector (18) arranged to receive light from the source after it has passed through the flow path; and a sensor element (19) comprising a scaffold moiety (20) with an aspect ratio of at least 75:1 disposed within the flow path and a receptor moiety (24), for the target molecule, attached to the scaffold moiety.
  2. The molecular sensor of any preceding claim comprising a plurality of scaffold moieties (20).
  3. The molecular sensor of any preceding claim wherein the or each scaffold moiety (20) has a plurality of receptor moietie (24) attached thereto.
  4. The molecular sensor of any preceding claim wherein the or each scaffold moiety (20) is anchored in the flow path such that, in use, the or each scaffold moiety is capable of alignment in a flow but its location is fixed within the flow path.
  5. The molecular sensor of any preceding claim additionally comprising a flow cell which is rotatable in use to generate flow in the solution.
  6. The molecular sensor of any preceding claim wherein the light source (16) is a source of linearly polarised beams of light.
  7. The molecular sensor of any preceding claim wherein the light source (16) is a linear dichroic spectroscope.
  8. The molecular sensor of any preceding claim wherein the detector (18) is one which generates a spectrum that illustrates the absorbance of the solution with respect to wavelength.
  9. The molecular sensor of any preceding claim wherein the light source (16) and detector (18) are arranged to respectively emit and detect light passing perpendicularly to the flow direction.
  10. A method for sensing a target molecule (26) in a flowing solution (28) comprising: providing in a flow path (12) a scaffold moiety (20) with an aspect ratio of at least 75:1 and having a receptor moiety (27), for the target molecule, attached thereto; flowing a solution (28) potentially containing a target molecule (26) along the flow path (12); passing polarised light through the flow path; and detecting the polarised light after it has passed through the flow path.

References Cited

Foreign Patent Documents

Document NumberAssigneesInventorsIssue/Pub Date
WO2004010117UNIVERSITY OF WARWICK

Other Publications

RODGER A: "CIRCULAR DICHROISM AND LINEAR DICHROISM" ENCYCLOPEDIA OF ANALYTICAL CHEMISTRY, 2000, pages 10305-10333, XP001153376
DAFFORN T R ET AL: "Protein Fiber Linear Dichroism for Structure Determination and Kinetics in a Low-Volume, Low-Wavelength Couette Flow Cell" BIOPHYSICAL JOURNAL, vol. 86, January 2004 (2004-01), pages 404-410, XP002471306 cited in the application
SOLIMANI R ET AL: "Flavonoid-DNA Interaction Studied with Flow Linear Dichroism Technique" J. AGRIC. FOOD CHEM., vol. 43, 1995, pages 876-882, XP002471307
CHEN R J ET AL: "Noncovalent functionalization of carbon nanotubes for highly specific electronic biosensors" PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC, US, vol. 100, no. 9, 29 April 2003 (2003-04-29), pages 4984-4989, XP002332682 ISSN: 0027-8424
DRECHSLER U ET AL: "Nanoparticles: Scaffolds for Molecular Recognition" CHEM. EUR. J., vol. 10, 5 November 2004 (2004-11-05), pages 5570-5579, XP002471308
YU C AND IRUDAYARAJ J: "Multiplex Biosensor Using Gold Nanorods" ANALYTICAL CHEMISTRY, vol. 79, no. 2, 15 January 2007 (2007-01-15), pages 572-579, XP002471309

Referenced By

The current document is not referenced by other documents.

Patent Family

Document NumberAssigneeInventorsIssue/Pub Date
GB0622956 UNIV BIRMINGHAM Dec 2006
EP2082215 THE UNIVERSITY OF BIRMINGHAM DAFFORN, TIMOTHY RICHARD, et al. Jul 2009
ES2396566 --