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US20090197265: EPIGENETIC ANALYSES

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Filing Information

Inventor(s) Bryan M. Turner · Laura P. O'Neill ·
Assignee(s) THE UNIVERSITY OF BIRMINGHAM , a university ·
Correspondent FULBRIGHT AND JAWORSKI LLP ·
Application Number US12162194
Filing date 01/25/2007
PCT 371 date 12/18/2008
Publication date 08/06/2009
Predicted expiration date 01/25/2027
U.S. Classifications 435/6  ·
International Classifications C12Q168  ·
Kind CodeA1
PCT Application Number WO20PCTGB2007000243 - 01/25/2007
Foreign Priority GB0601538.2 - 01/26/2006 ·
28 Claims, 4 Drawings


Abstract

A method of carrying out epigenetic analysis on an analyte biological sample, the method comprising carrying out chromatin immunoprecipitation on an analyte biological sample, characterised in that the method comprises a step of contacting the analyte biological sample with carrier chromatin. The method of the invention wherein the analyte biological sample comprises less than one million cells. The method of the invention wherein the analyte biological sample comprises less than about 6 μg of DNA and/or less than about 12 μg of chromatin.

Independent Claims | See all claims (28)

  1. 1. A method of carrying out epigenetic analysis on an analyte biological sample, the method comprising carrying out chromatin immunoprecipitation on an analyte biological sample, characterised in that the method comprises a step of contacting the analyte biological sample with carrier chromatin before the step of carrying out chromatin immunoprecipitation on the analyte biological sample.
  2. 8. (canceled)
  3. 17. A method of identifying histone protein modification, non-histone protein modification, and/or DNA methylation, or patterns thereof, in an analyte biological sample, the method comprising carrying out chromatin immunoprecipitation on an analyte biological sample, characterised in that the method comprises a step of contacting the analyte biological sample with carrier chromatin before the step of carrying out chromatin immunoprecipitation on the analyte biological sample.
  4. 23. A method of carrying out epigenetic analysis on a sample of stem cells or a stem cell precursor, the method comprising carrying out chromatin immunoprecipitation on a sample of stem cells or a stem cell precursor, characterised in that the method comprises a step of contacting the stem cells or stem cell precursor with carrier chromatin before the step of carrying out chromatin immunoprecipitation on the sample of stem cells or stem cell precusor.
  5. 27. An epigenetic analysis kit comprising one or more materials for performing chromatin immunoprecipitation, characterised in that the kit further comprises carrier chromatin.

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Referenced By

Document NumberAssigneeInventorsIssue/Pub Date
US7960009 Corning Incorporated Monika Backhaus-Ricoult et al. Jun 2011

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