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US20090222085: Cellulose Based Heart Valve Prosthesis

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Filing Information

Inventor(s) Vijay Kumar ·
Assignee(s) UNIVERSITY OF IOWA RESEARCH FOUNDATION ·
Correspondent MCDONNELL BOEHNEN HULBERT & BERGHOFF LLP ·
Application Number US12391249
Filing date 02/23/2009
Publication date 09/03/2009
Predicted expiration date 02/23/2029
U.S. Classifications 623/242  · 600/36  · 623/126  ·
International Classifications A61F206  · A61F224  ·
Kind CodeA1
25 Claims, 10 Drawings


Abstract

Disclosed are cellulose-based pliable, porous and non-porous prosthesis structures that can be formed to various geometries such as thin films, membranes, hollow tubes, heart valves, including an aortic heart valve. Also disclosed are methods for preparing a cellulose-based porous prosthesis structure.

Independent Claims | See all claims (25)

  1. 1. A single-pieced, cellulose-based heart valve prosthesis comprising (a) a stent body; and (b) a plurality of leaflet-forming membranes, wherein (i) the stent body defines a generally tubular shape centered about an axis; and (ii) the plurality of leaflet-forming membranes are located within the stent body so as to form a one-way valve prosthesis, wherein the valve prosthesis comprises a proximal end and a distal end.
  2. 6. A method for preparing a cellulose-based porous structure comprising (a) providing a source of cellulose; (b) treating the cellulose with paraformaldehyde in anhydrous dimethylsulfoxide (DMSO) under conditions suitable to form methylolcellulose; (c) mixing the methylolcellulose with a water-soluble porogen; (d) casting the methylolcellulose and porogen mixture in an appropriate mold; (e) soaking the methylolcellulose and porogen in a DMSO-miscible organic solvent or mixed solvent system under conditions suitable to form a solid methylolcellulose-porogen matrix; (f) removing the matrix from the mold and soaking the solid matrix in water until the solid cellulose-based porous structure is formed.
  3. 10. A method for preparing a cellulose-based porous heart valve prosthesis formed as a single unit comprising: (a) providing a source of cellulose; (b) treating the cellulose with paraformaldehyde in anhydrous dimethylsulfoxide (DMSO) under conditions suitable to form methylolcellulose; (c) mixing the methylolcellulose with a water-soluble porogen; (d) casting the methylolcellulose and porogen mixture in an appropriate mold; (e) soaking the methylolcellulose matrix in a DMSO-miscible organic solvent or mixed solvent system under conditions suitable to form a solid methylolcellulose matrix; and (f) removing the matrix from the mold and soaking the solid matrix in water until the solid cellulose heart valve is formed, wherein the mold comprises the shape of a heart valve and stent body.
  4. 17. A method for preparing a cellulose-based structure comprising (a) providing a source of cellulose; (b) treating the cellulose with paraformaldehyde in anhydrous dimethylsulfoxide (DMSO) under conditions suitable to form methylolcellulose; (c) casting the methylolcellulose in an appropriate mold; and (d) removing the solidified methylolcellulose matrix from the mold and soaking the solid matrix in water until the solid cellulose-based structure is formed.
  5. 18. A method for preparing a cellulose-based heart valve prosthesis formed as a single unit comprising: (a) providing a source of cellulose; (b) treating the cellulose with paraformaldehyde in anhydrous dimethylsulfoxide (DMSO) under conditions suitable to form methylolcellulose; (c) casting the methylolcellulose in an appropriate mold; and (d) removing the solidified methylolcellulose matrix from the mold and soaking the solid matrix in water until the solid cellulose-based heart valve is formed, wherein the mold comprises the shape of a heart valve and stent body.
  6. 21. A single-pieced, cellulose-based heart valve prosthesis comprising (a) a stent body; and (b) at least one leaflet-forming membrane, wherein (i) the stent body defines a generally tubular shape centered about an axis; and (ii) the at least one leaflet-forming membrane is located within the stent body so as to form a one-way valve prosthesis, wherein the valve prosthesis comprises a proximal end and a distal end.

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