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US20090296744: Laser Based Identification of Molecular Characteristics

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Filing Information

Inventor(s) Marcos Dantus · Vadim V. Lozovoy ·
Assignee(s) BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY ·
Correspondent HARNESS, DICKEY & PIERCE, P.L.C. ·
Application Number US12085878
Filing date 11/29/2006
PCT 371 date 06/17/2009
Publication date 12/03/2009
Predicted expiration date 11/29/2026
U.S. Classifications 372/5  · 250/286  · 250/282  · 372/25  · 356/364  · 372/27  ·
International Classifications B01D5944  · G01J400  · H01J4940  · H01S310  · H01S330  ·
Kind CodeA1
PCT Application Number WO20PCTUS2006045686 - 11/29/2006
47 Claims, 5 Drawings


Abstract

Enantiomers are characterized, identified, synthesized and/or modified with a shaped laser pulse. In another aspect of the present invention, binary shaping and circular polarization are employed with a laser pulse. A further aspect of the present invention provides a quarter-wave plate in combination with one or more pulse shapers.

Independent Claims | See all claims (47)

  1. 1. A method of manufacturing a pharmaceutical compound, the method comprising: (a) emitting a laser beam; (b) shaping the laser beam; (c) polarizing the laser beam; (d) testing the pharmaceutical compound with the shaped and polarized laser beam; (e) automatically determining a chiral property of the pharmaceutical compound based on the test; and (f) creating a substantially helical and propeller-like direction and curvature of the polarized and shaped laser beam to cause enantiomeric selectivity.
  2. 2. (canceled)
  3. 11. A method of manufacturing a pharmaceutical product, the method comprising: (a) emitting a set of laser beam pulses on the pharmaceutical product, each of the pulses having a duration of less than 100 femtoseconds; (b) shaping the pulses to control phase and amplitude in the pulses; (c) automatically detecting and compensating for distortions in the pulses, without a genetic learning algorithm; (d) polarizing the pulses after step (b) to control the electric field direction therein; and (e) detecting or changing a characteristic of the pharmaceutical product with the shaped and polarized pulses.
  4. 19. A method of operating a laser system, the method comprising: (a) emitting a laser beam pulse; (b) minimizing phase distortions of the pulse by pulse shaping without a genetic learning algorithm; and (c) polarization shaping of the pulse after step (b).
  5. 22-24. (canceled)
  6. 28. A method of operating a laser system, the method comprising using at least two of: (a) vertical linear, (b) horizontal linear, (c) right circular, and (d) left circular, pulse shapes to test essentially all possible pulse shapes for determining chiral sensitivity in a specimen.
  7. 29-31. (canceled)
  8. 37. A method of operating a laser system, the method comprising: (a) emitting a laser pulse; (b) shaping the pulse including polarization; and (c) detecting secondary structure of a specimen in response to interaction of the shaped pulse on the specimen.
  9. 40-50. (canceled)
  10. 51. A laser system comprising: a laser operably emitting laser beam pulses, each being less than 1000 fs in duration and having a bandwidth greater than 10 nm; at least one device operably linearly and circularly polarizing the pulses; a spectrometer; and a controller connected to the spectrometer and device; the controller automatically causing the device to vary the polarization based at least in part on a signal from the spectrometer, and without a genetic learning algorithm.
  11. 52-57. (canceled)
  12. 58. A laser system comprising: an ultraviolet laser pulse having a center wavelength shorter than about 420 nm and a bandwidth greater than about 10 nm; an adaptive shaper operably varying a characteristic of the pulse; and a detector operably detecting a chiral property of a specimen.
  13. 60-62. (canceled)
  14. 63. A laser system comprising: laser pulses having a second or third order harmonic wavelength; a shaper operably varying a characteristic of the pulses; a polarizer operably polarizing the pulses; and a detector operably detecting a chiral characteristic of a specimen acted upon by the shaped and polarized pulses.
  15. 64-67. (canceled)
  16. 68. A method of manufacturing a pharmaceutical compound, the method comprising: (a) emitting a laser beam; (b) shaping the beam; (c) polarizing the laser beam; (d) using at least two of: (i) zero, (ii) π, (iii) right, and (iv) left, circular polarization to test for effectiveness in determining chiral sensitivity to different laser beam shapes; and (e) detecting or changing a characteristic of the pharmaceutical compound with the shaped and polarized beam.

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