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US4382076: Hepatitis A antibody assay


Filing Information

Inventor(s) William M. Hurni · William J. Miller · William J. McAleer ·
Assignee(s) Merck & Co., Inc. ·
Attorney/Agent(s) Donald J. Perrella ·
Primary Examiner Anna P. Fagelson ·
Application Number US6383668
Filing date 06/01/1982
Issue date 05/03/1983
Predicted expiration date 05/03/2000
U.S. Classifications 436/531  · 436/820  ·
International Classifications G01N 3348  ·
Kind CodeA
International Classifications 4248;12;78 ·
Related U.S. Application DataRELATED APPLICATION
The present application is a continuation-in-part of copending application Ser. No. 97,299 filed Nov. 26, 1979, now abandoned.
5 Claims, No Drawings


A diagnostic reagent for hepatitis A antibody is prepared by adhering hepatitis A antibody to a surface by non-specific adsorption followed by specific coupling of hepatitis A antigen to the antibody. This reagent is useful in an in vitro assay for hepatitis A antibody.

Independent Claims | See all claims (5)

  1. 1. A method of preparing a diagnostic reagent for use in an assay for hepatitis A antibody comprising contacting an opaque or transparent surface, the surface being substantially free of metallic globules and having hepatitis A antibody adhered thereto, with a cell culture fluid containing hepatitis A antigen whereby the surface has an inner layer of hepatitis A antibody and an outer layer of hepatitis A antigen.

References Cited

U.S. Patent Documents

Document NumberAssigneesInventorsIssue/Pub Date
US4092116 General Electric Company Giaever May 1978
US4164566 Merck & Co., Inc. Provost Aug 1979

Other Publications

Hollos, Actamicrobiol Acad. Sci. Hung., vol. 22, 1975, pp. 168-178.
Ransom, Practical Competitive Binding Assay Methods Mosby Co., St. Louis, 1976 pp, 57-59.
Friedman, Immunoserol. in the Diag. of Inf Dis. Sym. ASM, Easton PA, 1977, University Park Press, 1979, pp. 92-103.
Abbott Lab, Antibody to Hepititis A Virus .sup.125 I (Human)/Hepatitis A Virus (Primate) HAVAB.TM., Radioimmunoassay for Detection of Antibody to Hepititis A Virus, flyer, 13 pp., Rev. Nov., 1978.

Patent Family

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