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US4601978: Mammalian metallothionein promoter system

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Filing Information

Inventor(s) Michael Karin ·
Assignee(s) The Regents of the University of California ·
Attorney/Agent(s) Townsend and Townsend ·
Primary Examiner Thomas G. Wiseman ·
Assistant Examiner James Martinell ·
Application Number US6444134
Filing date 11/24/1982
Issue date 07/22/1986
Predicted expiration date 07/22/2003
U.S. Classifications 435/68  · 435/70  ·
International Classifications C12N 120  ·
Kind CodeA
International Classifications 43568;70;91;172;253;317;240;241;172.3 ·
16 Claims, No Drawings


Abstract

A cloning vector comprises a replication system from a bovine papilloma virus, a regulatory system including the promoter and terminator from a human metallothionein II gene, and a prokaryotic replication system. The vector is useful for transforming mammalian cells where it is maintained as an automonously replicating episome. Transcription may be regulated by the presence of heavy metals and/or glucocorticoid hormones in the growth media.

Independent Claims | See all claims (16)

  1. 1. A DNA sequence of less than 500 base pairs, said DNA sequence comprising the human MT-II transcriptional regulatory system further comprising the transcription initiation sequence.
  2. 5. A DNA construct capable of regulated expression of an inserted gene in a mammalian host, said construct comprising an extrachromosomal replication system recognized by a mammalian host, which replication system has been joined to a human MT-II gene inducible regulatory system in vitro, said construct having DNA sequence(s) defining at least one restriction site within the transcriptional control of the regulatory region for insertion of the gene.
  3. 10. A DNA construct useful for expression of a structural gene to produce a polypeptide in a mammalian host, said vector comprising (a) a replicon from bovine papilloma virus and (b) a regulatory system from a human MT-II gene comprising a promoter and a terminator and having at least one restriction site downstream from the promoter in the direction of transcription.

References Cited

The current document has no citations.

Other Publications

Karin et al., Nucleic Acids Res. 10, 3165 (1982).
Durnam et al., Proc. Natl. Acad. Sci. USA 77, 6511 (1980).
Pulido et al., Biochemistry 5, 1768 (1966).
Brinster et al., Nature 296, 39 (1982).
Hager et al., Nature 291, 340 (1981).
Karin, Diss. Abstr. 40(9), 4084 (1980).
Douglas R. Lowy, et al,. Nature (1980) 287:72-74.
Ming-Fan Law et al., Proc. Natl. Acad. Sci. USA (1981) 78:2727-2731.
Sarver et al., Preprint of Mol. Cell Biol. (1981).

Referenced By

Document NumberAssigneeInventorsIssue/Pub Date
US6462176 Genentech, Inc. Avi J. Ashkenazi Oct 2002
US7314619 Genentech, Inc. Camellia W. Adams et al. Jan 2008
US7595046 Genentech, Inc. Camellia W. Adams et al. Sep 2009
US6740739 Genentech, Inc. Avi J. Ashkenazi et al. May 2004
US7285533 Genentech, Inc. Avi J. Ashkenazi Oct 2007
US6469144 Genentech, Inc. Avi J. Ashkenazi Oct 2002
US6746668 Genentech, Inc. Avi J. Ashkenazi Jun 2004
US6342369 Genentech, Inc. Avi J. Ashkenazi Jan 2002
US6589733 Osi Pharmaceuticals, Inc. J. Gordon Foulkes et al. Jul 2003
US6998116 Genentech, Inc. Avi J. Ashkenazi Feb 2006
US6407216 Genentech, Inc. Frederick J. de Sauvage et al. Jun 2002
US6376175 OSI Pharmaceuticals, Inc. J. Gordon Foulkes et al. Apr 2002
US7749755 Genentech, Inc. Avi J. Ashkenazi Jul 2010
US7750118 Genentech, Inc. Avi J. Ashkenazi Jul 2010
US7772365 Zymogenetics, Inc. Jane A. Gross et al. Aug 2010
US7807153 Genentech, Inc. Camellia W. Adams et al. Oct 2010
US7811984 Genentech, Inc. Napoleone Ferrara et al. Oct 2010
US7833529 ZymoGenetics, Inc. Jane A. Gross Nov 2010
US7842292 Ares Trading S.A. Herve Broly et al. Nov 2010
US7060278 Genentech, Inc. Napoleone Ferrara et al. Jun 2006
US7939631 Genentech, Inc. Avi J. Ashkenazi May 2011
US8012473 Genentech, Inc. Menno Van Lookeren Campagne Sep 2011
US8029783 Genentech, Inc. Camellia W. Adams et al. Oct 2011
US8030023 Genentech, Inc. Camellia W. Adams et al. Oct 2011
US8092799 Genentech, Inc. Camellia W Adams et al. Jan 2012
EP1889915 Genentech Inc. Avi J. Ashkenazi et al. Feb 2008
EP1939293 ZymoGenetics, Inc. Paul O. Sheppard et al. Jul 2008
EP1950300 Genentech, Inc. Yvonne M. Chen et al. Mar 2011
EP1958965 Genentech, Inc. Camelia W. Adams et al. Dec 2010
EP1927600 Zymogenetics, Inc. Lowell J. Brady et al. Jun 2008
EP1736545 ZymoGenetics, Inc. Wayne R. Kindsvogel et al. Dec 2006
EP1988102 ZymoGenetics, Inc. Zeren Gao et al. Nov 2008
EP1961811 ZymoGenetics, Inc. Cindy A. Sprecher et al. Aug 2010
EP0776970 F. Hoffmann-La Roche AG Randy Saiki et al. Jun 1997
US6159462 Genentech, Inc. William Matthews et al. Dec 2000
US5089397 California Biotechnology Inc. Peter J. Kushner et al. Feb 1992
US5482851 Genentech, Inc. Derynck; Rik M. A. et al. Jan 1996
US5643563 Chiron Corporation Martha B. Ladner et al. Jul 1997
US6103224 Chiron Corporation Martha B. Ladner et al. Aug 2000
US5681719 Chiron Corporation Martha B. Ladner et al. Oct 1997
US6165712 OSI Pharmaceuticals, Inc. Foulkes; J. Gordon et al. Dec 2000
US5846714 Chiron Corporation John Stephen Haskill et al. Dec 1998
US5846720 Oncogene Science, Inc. Foulkes; J. Gordon et al. Dec 1998
US5990281 Genentech, Inc. de Sauvage; Frederic J. et al. Nov 1999
US6030945 Genentech, Inc. Avi J. Ashkenazi Feb 2000
US6146851 Chiron Corporation Martha B. Ladner et al. Nov 2000
US5284763 Genentech, Inc. Derynk; Rik M. A. et al. Feb 1994
US5801231 Genentech, Inc. Derynck; Rik M. A. et al. Sep 1998
US6087178 Chiron Corporation John Stephen Haskill et al. Jul 2000
US6203976 OSI Pharmaceuticals, Inc. J. Gordon Foulkes et al. Mar 2001
US5672343 Chiron Corporation Martha B. Ladner et al. Sep 1997
US5851984 Genentech, Inc. William Matthews et al. Dec 1998
US4886747 Genentech, Inc. Derynck; Rik M. A. et al. Dec 1989
US5863733 Oncogene Science, Inc. Foulkes; J. Gordon et al. Jan 1999
US5580722 Oncogene Science, Inc. Foulkes; J. Gordon et al. Dec 1996
US5976793 Oncogene Science, Inc. Foulkes; J. Gordon et al. Nov 1999
US6204020 Chiron Corporation Martha B. Ladner et al. Mar 2001
US6136779 OSI Pharmaceuticals, Inc. Foulkes; J. Gordon et al. Oct 2000
US6270987 Genentech, Inc. Yang Wang et al. Aug 2001
US5665543 Oncogene Science, Inc. Foulkes; J. Gordon et al. Sep 1997
US5830756 Chiron Corporation John Stephen Haskill et al. Nov 1998
US6001582 The University of North Carolina John Stephen Haskill et al. Dec 1999
US6117422 Chiron Corporation Martha B. Ladner et al. Sep 2000
US6046048 Genetech, Inc. Avi J. Ashkenazi et al. Apr 2000
US6156300 Chiron Corporation Martha B. Ladner et al. Dec 2000
US6291643 Board of Reports, The University of Texas System Hua Zou et al. Sep 2001

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