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US4661458: Cell culture system


Filing Information

Inventor(s) Eric S. Berry · Bernard R. Danti ·
Assignee(s) Cell Environmental Systems, Ltd. ·
Attorney/Agent(s) Iver P. Cooper ·
Primary Examiner Robert J. Warden ·
Assistant Examiner Jeremy Jay ·
Application Number US6697864
Filing date 10/02/1984
PCT 371 date 10/02/1984
Issue date 04/28/1987
Predicted expiration date 04/28/2004
U.S. Classifications 435/284  · 435/240  ·
International Classifications C12M 300  ·
Kind CodeA
International Classifications 435240;241;285;286;284;311;313;316;813 ·
Related U.S. Application DataRELATED APPLICATION
This application is a continuation of our application Ser. No. 527,997, filed Aug. 31, 1983, abandoned, entitled CELL CULTURE SYSTEM, the disclosure of which is incorporated by reference herein.
PCT Application Number PCTUS8401350 - 08/22/1984
PCT Publication Number WO198501062 - 03/14/1985
4 Claims, No Drawings


A device is described which provides a totally enclosed and secure environment for the culture of cells and for the production of biologicals, pharmaceuticals, and other cell-derived products of commercial value. The device comprises several modules of differing functions: regulating the cellular growth environment, providing a suitable cell growth substrate or environment, or separating of desired product form interfering substances. Each module comprises a series of membranes separated by a solid support material which is channeled to provide a series of parallel capillaries for the flow of nutrients, environmental regulating fluids, or gas exchange. The structure and composition of the separating membranes limits the nature, rate, and size of the particular material exchanged across an individual membrane into or from an adjacent compartment. The capillaries are so dimensioned that the nutrients and gases are diffused over distances typical of human tissue.

Independent Claims | See all claims (4)

  1. 1. A cell growth system for the growth of cells and the recovery of desired metabolic products which comprises(a) a culture medium circulation means providing a plurality of separate, parallel medium channels into which the culture medium is distributed and from which it is withdrawn;(b) a cell growth means providing a plurality of separate, parallel culture channels into which cells may be introduced and where cell growth may occur, further providing means for removing the desired metabolic product or cells containing said product from said culture channels;(c) semipermeable membrane means separating said medium channels from said culture channels, said culture channels and medium channels being so dimensioned and disposed so that no cell is more than about 500 microns from the nearest source of nutrients, where each membrane contacts a plurality of culture channels and a plurality of medium channels, where each membrane has a molecular weight cutoff of at least 1000 daltons, and in which the channels have a depth of less than about 1000 microns and a width of less than about 1650 microns.

References Cited

U.S. Patent Documents

Document NumberAssigneesInventorsIssue/Pub Date
US3323653 Lacey Jun 1967
US3695444 IONICS Iaconelli Oct 1972
US3734851 MATSUMURA K Matsumura May 1973
US3827565 MATSUMURA K Matsumura Aug 1974
US4069157 E. I. Du Pont de Nemours and Company Hoover Jan 1978
US4124478 Tsien Nov 1978
US4225671 Battelle-Institut e.V. Puchinger Sep 1980
US4323455 Kuraray Co., Ltd. Tanaka Apr 1982
US4416993 McLeod & Miller (Engineers) Limited McKeown Nov 1983
US4540492 Millipore Corporation Kessler Sep 1985

Foreign Patent Documents

Document NumberAssigneesInventorsIssue/Pub Date
WO20WO8001043May 1980
GB1128181GORAN HEDENSep 1968

Other Publications

Feder, J. et al., Scientific American, vol. 248, No. 1, 1983, pp. 36-43.

Referenced By

Document NumberAssigneeInventorsIssue/Pub Date
EP1425379 ISIS INNOVATION LIMITED TRIFFITT, J. T., University of Oxford, Botnar R.C. et al. Jul 2006
EP0360837 BRUNSWICK CORPORATION Wolfgang J. WRASIDLO et al. Oct 1993
EP0814896 Henry B. Kopf Henry B. Kopf Sep 2002
US6566126 Fibercell Systems, Inc. John J. S. Cadwell May 2003
US7413284 FUJIFILM Dimatix, Inc. John A. Higginson et al. Aug 2008
US7316780 Pall Corporation Thomas J. Fendya et al. Jan 2008
US6933144 Fibercell Systems, Inc. John J. S. Cadwell Aug 2005
US7448741 FUJIFILM Dimatix, Inc. Kevin C. von Essen Nov 2008
US7514256 Emilio Barbera-Guillem Apr 2009
US6589790 Bio Merieux Bruno Colin et al. Jul 2003
US6878344 Symyx Technologies, Inc. Paul Mansky et al. Apr 2005
US7910361 Allen C. Barnes et al. Mar 2011
US7665815 Fujifilm Dimatix, Inc. David A. Swett et al. Feb 2010
US7673969 Fujifilm Dimatix, Inc. Paul A. Hoisington et al. Mar 2010
US7985058 Mark Gray Jul 2011
US8048315 Pall Corporation Thomas J. Fendya et al. Nov 2011
US8039252 Eric Berry Oct 2011
USD652446 FUJIFILM Dimatix, Inc. David A. Brady et al. Jan 2012
US8043512 Pall Corporation James A. Bair et al. Oct 2011
USD653284 FUJIFILM Dimatix, Inc. Frederick H. Amidon, Jr. et al. Jan 2012
US8231202 FUJIFILM Dimatix, Inc. Andreas Bibl et al. Jul 2012
US8517508 --
US8796015 --
USD414272 bioMerieux Vitek, Inc. Raymond E. O'Bear et al. Sep 1999
US5702945 Heraeus Instruments GmbH Hans-Otto Nagels et al. Dec 1997
US5981211 Regents of the University of Minnesota Wei-Shou Hu et al. Nov 1999
US6214574 Henry B. Kopf Apr 2001
US5187095 Baxter International Inc. Rudolf F. Bliem et al. Feb 1993
US5240854 BERRY ERIC S Eric S. Berry et al. Aug 1993
US5591636 Precision Instrument Design George M. Grass Jan 1997
US5102790 Baxter International Inc. Rudolf F. Bliem et al. Apr 1992
US5264344 University of Leicester Sneath; Peter H. A. Nov 1993
USD370263 Heraeus Instruments GmbH Frank W. Falkenberg et al. May 1996
US4693983 National Research Development Corporation Graham A. Davies et al. Sep 1987
US4937196 Brunswick Corporation Wolfgang J. Wrasidlo et al. Jun 1990
US5183760 SWEETANA STEPHANIE A Stephanie A. Sweetana et al. Feb 1993
US5015585 ROBINSON JAMES R James R. Robinson May 1991
US5153131 The United States of America as represented by the Administrator of the National Aeronautics and Space Administration David A. Wolf et al. Oct 1992
US5453270 Hypermetabolic Therapies, Inc. Nathan Bills Sep 1995
US6022742 Henry B. Kopf Feb 2000
US4895806 Millipore Ireland B.V. Minh S. Le et al. Jan 1990
US5599688 Precision Instrument Design George M. Grass Feb 1997
US5605835 Regents of the University of Minnesota Wei-Shou Hu et al. Feb 1997
US5686301 Heraeus Instruments GmbH Frank W. Falkenberg et al. Nov 1997
US5575910 Sartorius AG Massoud Karbachsch et al. Nov 1996
US6146883 Navicyte, Inc. George M. Grass Nov 2000
US6127141 Henry B. Kopf Oct 2000
US5658797 Augustinus Bader Aug 1997
US5190878 Minuth Wilhelm Mar 1993
US4912057 Cancer Diagnostics, Inc. Raouf A. Guirguis et al. Mar 1990
US5380437 Biomedical Research And Development Laboratories, Inc. Joseph Bertoncini Jan 1995

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