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US4661458: Cell culture system

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Filing Information

Inventor(s) Eric S. Berry · Bernard R. Danti ·
Assignee(s) Cell Environmental Systems, Ltd. ·
Attorney/Agent(s) Iver P. Cooper ·
Primary Examiner Robert J. Warden ·
Assistant Examiner Jeremy Jay ·
Application Number US6697864
Filing date 10/02/1984
PCT 371 date 10/02/1984
Issue date 04/28/1987
Predicted expiration date 04/28/2004
U.S. Classifications 435/284  · 435/240  ·
International Classifications C12M 300  ·
Kind CodeA
International Classifications 435240;241;285;286;284;311;313;316;813 ·
Related U.S. Application DataRELATED APPLICATION
This application is a continuation of our application Ser. No. 527,997, filed Aug. 31, 1983, abandoned, entitled CELL CULTURE SYSTEM, the disclosure of which is incorporated by reference herein.
PCT Application Number PCTUS8401350 - 08/22/1984
PCT Publication Number WO198501062 - 03/14/1985
4 Claims, No Drawings


Abstract

A device is described which provides a totally enclosed and secure environment for the culture of cells and for the production of biologicals, pharmaceuticals, and other cell-derived products of commercial value. The device comprises several modules of differing functions: regulating the cellular growth environment, providing a suitable cell growth substrate or environment, or separating of desired product form interfering substances. Each module comprises a series of membranes separated by a solid support material which is channeled to provide a series of parallel capillaries for the flow of nutrients, environmental regulating fluids, or gas exchange. The structure and composition of the separating membranes limits the nature, rate, and size of the particular material exchanged across an individual membrane into or from an adjacent compartment. The capillaries are so dimensioned that the nutrients and gases are diffused over distances typical of human tissue.

Independent Claims | See all claims (4)

  1. 1. A cell growth system for the growth of cells and the recovery of desired metabolic products which comprises(a) a culture medium circulation means providing a plurality of separate, parallel medium channels into which the culture medium is distributed and from which it is withdrawn;(b) a cell growth means providing a plurality of separate, parallel culture channels into which cells may be introduced and where cell growth may occur, further providing means for removing the desired metabolic product or cells containing said product from said culture channels;(c) semipermeable membrane means separating said medium channels from said culture channels, said culture channels and medium channels being so dimensioned and disposed so that no cell is more than about 500 microns from the nearest source of nutrients, where each membrane contacts a plurality of culture channels and a plurality of medium channels, where each membrane has a molecular weight cutoff of at least 1000 daltons, and in which the channels have a depth of less than about 1000 microns and a width of less than about 1650 microns.

References Cited

U.S. Patent Documents

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US3323653 Lacey Jun 1967
US3695444 IONICS Iaconelli Oct 1972
US3734851 MATSUMURA K Matsumura May 1973
US3827565 MATSUMURA K Matsumura Aug 1974
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Foreign Patent Documents

Document NumberAssigneesInventorsIssue/Pub Date
WO20WO8001043May 1980
GB1128181GORAN HEDENSep 1968

Other Publications

Feder, J. et al., Scientific American, vol. 248, No. 1, 1983, pp. 36-43.

Referenced By

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EP1425379 ISIS INNOVATION LIMITED TRIFFITT, J. T., University of Oxford, Botnar R.C. et al. Jul 2006
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