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US4797368: Adeno-associated virus as eukaryotic expression vector

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Filing Information

Inventor(s) Barrie J. Carter · Jon D. Tratschin ·
Assignee(s) The United States of America as represented by the Department of Health and Human Services ·
Attorney/Agent(s) Holman & Stern ·
Primary Examiner Thomas G. Wiseman ·
Assistant Examiner Stephanie Seidman ·
Application Number US6712236
Filing date 03/15/1985
Issue date 01/10/1989
Predicted expiration date 01/10/2006
U.S. Classifications 435/320  · 435/68  ·
International Classifications C12N 700  ·
Kind CodeA
International Classifications 435172.3;240;317;68;235;91;70;320;235 ·
4 Claims, No Drawings


Abstract

The present invention relates to a vector comprising part of AAV DNA contained in a plasmid and capable of being packaged into AAV particles and functioning as a vector for stable integration and expression of a gene in eukaryotic cells when under control of an AAV transcription promoter. A method of preparing such plasmids which are packagable and rescuable is also described.

Independent Claims | See all claims (4)

  1. 1. A vector comprising part of AAV DNA contained in a plasmid and capable of being packaged into AAV particles and functioning as a vector for stable maintenance or expression of a gene or a DNA sequence in eukaryotic cells when under control of an AAV transcription promotor.

References Cited

U.S. Patent Documents

Document NumberAssigneesInventorsIssue/Pub Date
US4419446 The United States of America as represented by the Department of Health and Human Services Howley et al. Dec 1983

Other Publications

Tratschin, J. et al. (Sep. 1984) J. Virol 51:611-619.
Tratschin, J. et al. (Oct. 1984) Molec. Cell. Biol. 4:2072-2081.
Hermonat, P. and N. Muzyczka (Oct. 1984) PNAS 81:6466-6470.
Laughlin et al., Gene, 23 (1983) 65-73.

Referenced By

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