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US4837285: Collagen matrix beads for soft tissue repair

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Filing Information

Inventor(s) Richard A. Berg · Frederick H. Silver · James M. Pachence ·
Assignee(s) MediMatrix ·
Attorney/Agent(s) Michael Ebert ·
Primary Examiner John Kight ·
Assistant Examiner Nathan M. Nutter ·
Application Number US7093826
Filing date 09/08/1987
Issue date 06/06/1989
Predicted expiration date 06/06/2006
U.S. Classifications 530/356  · 523/105  ·
International Classifications C08H 106  ·
Kind CodeA
International Classifications 530356 ·
Related U.S. Application DataCROSS-REFERENCE TO RELATED APPLICATIONS
This application is a continuation-in-part of copending application Ser. No. 875,827 filed June 18 ,1986;which was a continuation -in-part of application Ser. No. 843,828 filed Mar. 26, 1986 and now U.S. Pat. No. 4,703,108; which application was in turn a continuation of application Ser. No. 593,733 filed Mar. 27, 1984, now abandoned.
15 Claims, No Drawings


Abstract

Collagen-based compositions for augmenting soft tissue, wound dressings, implants, injectable formulations or other drug delivery systems, comprising resorbable collagen matrix beads, the beads having an average pore size of from 50 to 350 microns, and the collagen comprising from 1 to 30% by volume of the beads, the collagen matrix being sufficiently open to stimulate cellular ingrowth therethrough and yet sufficiently stiff and non-compressible to fill and protect a wound, and the formulation being sufficiently moisture and gas permeable to prevent liquid pooling on a wound and to permit sufficient oxygen diffusion for promoting wound healing.

Independent Claims | See all claims (15)

  1. 1. A wound dressing or implant comprising resorbable, porous collagen matrix beads having particle sizes of from about 100 to 4000 microns, the beads having an average pore size of from about 50 to 350 microns, and the collagen comprising from 1 to 30% by volume of the beads, the porous collagen matrix forming a skeleton providing a volume sufficient for cells to attach and grow into the matrix and being stiff and non-compressible to a degree sufficient to fill and protect a wound, the dressing or implant having a degree of moisture and gas permeability sufficient to prevent liquid pooling on a wound and to permit sufficient oxygen diffusion for promoting wound healing.
  2. 8. A compostion for injection into a wound site in mammals for promoting soft tissue augmentation, comprising a suspension of resorbable, porous native collagen matrix beads having particle sizes of about 100 to 4000 microns in an aqueous medium, the beads having an average pore size of 50 to 350 microns, the collagen comprising from 1 to 30% by volume of the beads, the porous collagen matrix beads forming a skeleton providing a volume sufficient for cells to attach and grow into the matrix, and being stiff and non-compressible to a degree sufficient to conform to the tissue to be repaired.

References Cited

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