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US4937196: Membrane bioreactor system

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Filing Information

Inventor(s) Wolfgang J. Wrasidlo · Frieder K. Hofmann · Dirk M. deWinter ·
Assignee(s) Brunswick Corporation ·
Attorney/Agent(s) Waldron & Associates ·
Primary Examiner Larry Jones ·
Application Number US7395655
Filing date 08/18/1989
Issue date 06/26/1990
Predicted expiration date 08/18/2009
U.S. Classifications 435/313  · 435/284  ·
International Classifications C12M 104  ·
Kind CodeA
International Classifications 435313;310;284;287;240.242;286 ·
Related U.S. Application DataThis application is a continuation of applicant's copending application, Ser. No. 07/068,203, filed Jun. 30, 1987, now abandoned benefit of which is hereby claimed under 35 U.S.C. 120.
25 Claims, No Drawings


Abstract

A bioreactor is disclosed in which cells are confined to a compartment formed by porous hydrophyllic sheet membranes through which a nutrient solution diffuses in and exocellular products and metabolic waste diffuse out. Adjacent gas compartments allow the flow of free oxygen into the cell compartment. Each cell compartment is configured to place cells within about 100-200 micrometers of the oxygen transport membrane.

Independent Claims | See all claims (25)

  1. 1. A cell reactor comprising:A. at least one layered cell reactor compartment for confining and retaining living cells and nutrient solution to produce exocellular products,B. at least one associated nutrient compartment for feeding liquid cell nutrients to each said cell reactor compartment and for the removal of exocellular products and metabolic wastes from said cell reactor compartment,C. each said cell reactor compartment and said associated nutrient compartment having a common boundary formed by a porous hydrophyllic sheet membrane having a pore size adapted to permit flow therethrough by diffusion of nutrient, exocellular products and metabolic wastes, and preventing passage therethrough of cells,D. at least one associated gas compartment for the supply of free oxygen into solution in nutrient solution in each said cell reactor compartment,E. each said cell reactor compartment and said associated gas compartment having a common boundary formed by an oxygen transport membrane adapted to permit flow therethrough of free oxygen and adapted to prevent flow of cells, nutrient, exocellular products and metabolic wastes into said gas compartment,F. each said cell reactor compartment and said associated oxygen transport membrane being disposed so that substantially all cells within said cell reactor compartment are within effective oxygen diffusion distance of up to about 100 micrometers to about 200 micrometers of said oxygen transport membrane, said oxygen diffusion distance being effective to maintain cell viability and cell densities greater than about 5.times.108 cells per milliliter by transport of dissolved oxygen from said oxygen transport membrane to said cells solely by diffusion; andG. each said cell reactor compartment layer is separated from each adjacent cell reactor chamber layer by either (i) a nutrient transport compartment or (ii) a gas compartment on one side and a nutrient transport compartment on an opposite side.

References Cited

U.S. Patent Documents

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Foreign Patent Documents

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Other Publications

Biotechnology and Bioengineering, vol. XXIII, pp. 79-95 (1981), (K. Ku et al.), "Development of a Hollow-Fiber System for Large-Scale Culture of Mammalian Cells", see pp. 83-94.

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