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US5108438: Prosthetic intervertebral disc

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Filing Information

Inventor(s) Kevin R. Stone ·
Assignee(s) ReGen Corporation ·
Attorney/Agent(s) Lahive & Cockfield ·
Primary Examiner David Isabella ·
Application Number US7520027
Filing date 05/07/1990
Issue date 04/28/1992
Predicted expiration date 04/28/2009
U.S. Classifications 623/17  ·
International Classifications A61F 244  ·
Kind CodeA
International Classifications 62311;12;16;17;18;20;23;66;1 ·
Related U.S. Application DataCROSS-REFERENCE TO RELATED APPLICATION
This application is a continuation-in-part applicant's copending U.S. Patent Application serial no 317,951, now U.S. Pat. No. 5,007,934, entitled "PROSTHETIC MENISCUS", filed Mar. 2, 1989, which is a continuation-in-part of U.S. Patent Application Ser. No. 075,352, entitled "PROSTHETIC MENISCUS", filed July 20, 1987, now U.S. Pat. No. 4,880,429. U.S. Patent Application Ser. No. 317,951 is incorporated herein by reference.
27 Claims, No Drawings


Abstract

A prosthetic intervertebral disc is disclosed which can be implanted in the human skeleton, and which can act as a scaffold for regrowth of intervertebral disc material. The disc includes a dry, porous, volume matrix of biocompatible and bioresorbable fibers which may be interspersed with glyscosaminoglycan molecules. The matrix is adapted to have in vivo an outer surface contour substantially the same as that of a natural intervertebral disc, whereby said matrix establishes an at least partially bioresorbable scaffold adapted for ingrowth of intervertebral fibrochondrocytes. Cross-links may be provided by a portion of the GAG molecules.

Independent Claims | See all claims (27)

  1. 1. A prosthetic intervertebral disc comprising a dry, porous volume matrix of biocompatible and bioresorbable fibers, said fibers selected from the group consisting of natural polymers, and analogs and mixtures thereof,said matrix being adapted to have in vivo an outer surface contour substantially the same as that of a natural intervertebral disc,whereby said matrix establishes an at least partially bioresorbable scaffold adapted for ingrowth of vertebral fibrochondrocytes, and wherein said scaffold and said ingrown vertebral fibrochondrocytes support natural intervertebral load forces.
  2. 24. A method of regenerating intervertebral tissue in vivo comprising the steps of:(a) fabricating a prosthetic intervertebral disc comprising a dry porous volume matrix of biocompatible and bioresorbable fibers, said fibers selected from the group consisting of natural polymers, and analogs and mixtures thereof,said matrix being adapted to have in vivo an outer surface contour substantially the same as that of a natural intervertebral disc, whereby said matrix establishes an at least partially bioresorbable scaffold adapted for ingrowth of vertebral fibrochondrocytes, and wherein said scaffold and said ingrown vertebral fibrochondrocytes support natural intervertebral load forces; and(b) implanting said disc into a spine by surgical procedures.said implanted disc stimulating regeneration of intervertebral tissue.

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