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US5108755: Biodegradable composites for internal medical use

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Filing Information

Inventor(s) Alma U. Daniels · Jorge Heller ·
Assignee(s) SRI International · University of Utah ·
Attorney/Agent(s) Morrison & Foerster ·
Primary Examiner Thurman K. Page ·
Assistant Examiner William E. Benston ·
Application Number US7345034
Filing date 04/27/1989
Issue date 04/28/1992
Predicted expiration date 04/28/2009
U.S. Classifications 424/426  · 524/417  ·
International Classifications A61F 200  ·
Kind CodeA
International Classifications 424426;78 ·
10 Claims, No Drawings


Abstract

A family of composites suitable for use as materials of construction for implantable medical devices is disclosed. In the most preferred embodiment, the substrate polymer is an ortho ester polymer formed by the reaction of a ketene acetal having a functionality of two or more with a polyol. Also in the most preferred embodiment, the reinforcement material in the composites is calcium-sodium metaphosphate ("CSM") fibers. In other embodiments, the composites may replace either (but not both) of the substrate or the reinforcement with materials of the art.

Independent Claims | See all claims (10)

  1. 1. A reinforced bioerodible composite having a polymer substrate phase and dispersed therethrough a fiber reinforcement phase in a weight ratio of said polymer substrate phase to said fiber reinforcement phase of from 10:90 to 90:10, said polymer substrate phase being selected from the group consisting of poly(ortho ester), poly(levo lactic acid), poly(d/l lactic acid), poly(glycolic acid), the poly(ethyl ether) polydioxanone, L-lactide, epsilon-caprolactone, polycaprolactone, polyanhydrides, polypropylene fumarate, polyiminocarbonate, polyhydroxybutrate, polyhydroxyvalerate, poly(alkylene oxalate) and poly(ester-amide) and mixtures and copolymers thereof and said fiber reinforcement phase being selected from the group consisting of calcium-sodium metaphosphate, calcium phosphate, oriented poly(glycolic acid), oriented poly(lactic acid), sodium-calcium-aluminum polyphosphate, and mixtures thereof, subject to the proviso that when said polymer substrate phase is other than poly(ortho ester), said fiber reinforcement phase must include calcium-sodium metaphosphate and that when said fiber reinforcement phase is other than calcium-sodium metaphosphate, said polymer substrate phase must include poly(ortho ester).

References Cited

U.S. Patent Documents

Document NumberAssigneesInventorsIssue/Pub Date
US3640741 HOLLISTER INC Etes Feb 1972
US3739773 AMERICAN CYANAMID CO Schmitt Jun 1973
US4093709 Alza Corporation Choi et al. Jun 1978
US4096239 Syntex Corporation Katz et al. Jun 1978
US4304767 SRI International Heller et al. Dec 1981
US4346028 Monsanto Company Griffith Aug 1982
US4513143 SRI International Ng et al. Apr 1985
US4532335 SRI International Helwing Jul 1985
US4639366 Merck & Co., Inc. Heller Jan 1987
US4717487 Monsanto Company Griffith et al. Jan 1988
US4764364 S R I International Heller et al. Aug 1988
US4786664 General Electric Company Yates Nov 1988

Foreign Patent Documents

Document NumberAssigneesInventorsIssue/Pub Date
EP0031223MONSANTO COMPANYJul 1981
EP0146398Southern Research InstituteJun 1985
GB2169914MITSUBISHI MINING & CEMENT COJul 1986

Referenced By

Document NumberAssigneeInventorsIssue/Pub Date
AU2001262159 UNIV GENT SCHACHT ETIENNE HONORE Jul 2005
AU757775 BTG INT LTD CORDEN THOMAS JOSEPH et al. Mar 2003
EP1267953 UNIVERSITEIT GENT SCHACHT, Etienne, Honor Jun 2006
EP1588724 NGK SPARK PLUG CO., LTD Mizutani, Yoiohiro, c/o NGK Spark Plug Co. Ltd. et al. Oct 2005
EP1005379 THE UNIVERSITY OF NOTTINGHAM Thomas Joseph CORDEN et al. Feb 2004
EP1142596 UNIVERSITEIT GENT Etienne Honor Schacht Oct 2001
EP0627911 BOARD OF REGENTS THE UNIVERSITY OF TEXAS SYSTEM Jeffrey A. HUBBELL et al. Oct 2000
US6074840 The Regents of The University of Michigan Jeffrey Bonadio et al. Jun 2000
US6306922 Boards of Regents, The University of Texas System Jeffrey A. Hubbell et al. Oct 2001
US5962427 The Regent of the University of Michigan Steven A. Goldstein et al. Oct 1999
US6060582 The Board of Regents, The University of Texas System Jeffrey A. Hubbell et al. May 2000
US5462990 Board of Regents, The University of Texas System Jeffrey A. Hubbell et al. Oct 1995
US5763416 The Regent of the University of Michigan Jeffrey Bonadio et al. Jun 1998
US6333193 Nipro Corporation Toshikazu Shiba Dec 2001
USRE37410 Massachusetts Institute of Technology Henny Brem et al. Oct 2001
US6232384 BMG Inc. Suong-Hyu Hyon May 2001
US6077989 Rita Kandel et al. Jun 2000
US6160084 Massachusetts Institute of Technology Robert S. Langer et al. Dec 2000
US6300127 Emory University Gregory A. Hair et al. Oct 2001
US5942496 The Regent of The University of Michigan Jeffrey Bonadio et al. Aug 1999
US5785993 Focal, Inc. Keith Baker et al. Jul 1998
US5902599 Massachusetts Institute of Technology Kristi S. Anseth et al. May 1999
US6160240 Biotronik Mess-und Therapiegerate GmbH & Co Ingenieurburo Berlin Carslen Momma et al. Dec 2000
US5410016 Board of Regents, The University of Texas System Jeffrey A. Hubbell et al. Apr 1995
US5637113 Advanced Cardiovascular Systems, Inc. Joseph M. Tartaglia et al. Jun 1997
US5707385 Advanced Cardiovascular Systems, Inc. Michael S. Williams Jan 1998
US5874509 Clemson University Shalaby W. Shalaby et al. Feb 1999
US5700286 Advanced Cardiovascular Systems, Inc. Joseph M. Tartaglia et al. Dec 1997
US5629077 Advanced Cardiovascular Systems, Inc. Todd H. Turnlund et al. May 1997
US5626863 Board of Regents, The University of Texas System Jeffrey A. Hubbell et al. May 1997
US5766710 Advanced Cardiovascular Systems, Inc. Todd Hanson Turnlund et al. Jun 1998
US6251136 Advanced Cardiovascular Systems, Inc. Judy A. Guruwaiya et al. Jun 2001
US6585757 Advanced Cardiovascular Systems, Inc. Joseph R. Callol Jul 2003
US7309232 Dentigenix Inc. Bruce Rutherford et al. Dec 2007
US6444803 Emory University Gregory A. Hair et al. Sep 2002
US6774105 The Regents of the University of Michigan Jeffrey Bonadio et al. Aug 2004
US6822000 AP Pharma, Inc. Steven Y. Ng et al. Nov 2004
US7201940 Advanced Cardiovascular Systems, Inc. Pamela A. Kramer Apr 2007
US7258891 Advanced Cardiovascular Systems, Inc. Stephen D. Pacetti et al. Aug 2007
US7297159 Advanced Cardiovascular Systems, Inc. Syed F. A. Hossainy et al. Nov 2007
US7416558 Advanced Cardiovascular Systems, Inc. Philip S. Yip et al. Aug 2008
US6605114 Advanced Cardiovascular Systems, Inc. John Y. Yan et al. Aug 2003
US6946145 A.P. Pharma, Inc. Steven Y. Ng et al. Sep 2005
US7077860 Advanced Cardiovascular Systems, Inc. John Y. Yan et al. Jul 2006
US7329366 Advanced Cardiovascular Systems Inc. David C. Gale et al. Feb 2008
US7297758 Advanced Cardiovascular Systems, Inc. David C. Gale et al. Nov 2007
US6537589 Kyung Won Medical Co., Ltd. Soo Kyung Chae et al. Mar 2003
US7455674 Smith & Nephew PLC John Rose Nov 2008
US7413574 Advanced Cardiovascular Systems, Inc. Philip S. Yip et al. Aug 2008
US6388043 MnemoScience GmbH Robert S. Langer et al. May 2002
US7012106 Ethicon, Inc. Jenny J. Yuan et al. Mar 2006
US7105018 Advanced Cardiovascular Systems, Inc. Philip S. Yip et al. Sep 2006
US7217744 mnemoScience GmbH Andreas Lendlein et al. May 2007
US7514122 Advanced Cardiovascular Systems, Inc. Pamela A. Kramer Apr 2009
US7622070 Advanced Cardiovascular Systems, Inc. Svava Maria Atladottir et al. Nov 2009
US6527801 Advanced Cardiovascular Systems, Inc. Debashis Dutta Mar 2003
US6776792 Advanced Cardiovascular Systems Inc. John Y. Yan et al. Aug 2004
US6858431 Medtronic Sofamor Danek Gregory A. Hair et al. Feb 2005
US7144422 Advanced Cardiovascular Systems, Inc. K. T. Venkateswara Rao Dec 2006
US7163715 Advanced Cardiovascular Systems, Inc. Pamela A. Kramer Jan 2007
US6626950 Ethicon, Inc. Kelly R. Brown et al. Sep 2003
US6720402 MnemoScience GmbH Robert S. Langer et al. Apr 2004
US6702849 Advanced Cardiovascular Systems, Inc. Debashis Dutta et al. Mar 2004
US7291166 Advanced Cardiovascular Systems, Inc. E. Tina Cheng et al. Nov 2007
US7186789 Advanced Cardiovascular Systems, Inc. Syed F. A. Hossainy et al. Mar 2007
US6464723 Advanced Cardiovascular Systems, Inc. Joseph R. Callol Oct 2002
US6551618 University of Birmingham Andrew Baird et al. Apr 2003
US6602975 Board of Regents, The University of Texas System Jeffrey A. Hubbell et al. Aug 2003
US7381048 Advanced Cardiovascular Systems, Inc. Daniel Gene Brown et al. Jun 2008
US7553377 Advanced Cardiovascular Systems, Inc. Yung-Ming Chen et al. Jun 2009
US6406711 Jin-Yong Lee Jin-Yong Lee et al. Jun 2002
US6471993 Massachusetts Institute of Technology Venkatram R. Shastri et al. Oct 2002
US6652579 Advanced Cardiovascular Systems, Inc. Daniel L. Cox et al. Nov 2003
US6521750 UNIV EMORY Gregory A. Hair et al. Feb 2003
US6933328 Universiteit Gent Etienne Honor Schacht Aug 2005
US6780427 Genzyme Corporation Keith Baker et al. Aug 2004
US7220414 A.P. Pharma, Inc. Stephen J. Brocchini et al. May 2007
US7563324 Advanced Cardiovascular Systems Inc. Yung-Ming Chen et al. Jul 2009
US7588550 The Trustees of Columbia University in the City of New York Edward F. Leonard et al. Sep 2009
US6602287 Advanced Cardiovascular Systems, Inc. Deborra Sanders Millare et al. Aug 2003
US7312299 Advanced Cardiovascular Systems, Inc. Syed F. A. Hossainy et al. Dec 2007
US7604700 Advanced Cardiovascular Systems, Inc. Jason Fox et al. Oct 2009
US7470283 Advanced Cardiovascular Systems, Inc. Debashis Dutta Dec 2008
US7229471 Advanced Cardiovascular Systems, Inc. David C. Gale et al. Jun 2007
US7198675 Advanced Cardiovascular Systems Jason Fox et al. Apr 2007
US7301001 Advanced Cardiovascular Systems, Inc. Syed F. A. Hossainy et al. Nov 2007
US7390333 Advanced Cardiovascular Systems, Inc. Debashis Dutta Jun 2008
US7435255 Advnaced Cardiovascular Systems, Inc. K. T. Venkateswara Rao Oct 2008
US7524891 Smith & Nephew PLC John Rose et al. Apr 2009
US7867547 Advanced Cardiovascular Systems, Inc. Andrew J. Tochterman et al. Jan 2011
US7875233 Advanced Cardiovascular Systems, Inc. Bin Huang et al. Jan 2011
US7875283 Advanced Cardiovascular Systems, Inc. Syed F. A. Hossainy et al. Jan 2011
US7875697 Medtronic, Inc. Julie A. Alkatout et al. Jan 2011
US7886419 Advanced Cardiovascular Systems, Inc. Bin Huang et al. Feb 2011
US7901452 Abbott Cardiovascular Systems Inc. David C. Gale et al. Mar 2011
US7658880 Advanced Cardiovascular Systems, Inc. Patrick P. Wu Feb 2010
US7662326 Advanced Cardiovascular Systems, Inc. David C. Gale et al. Feb 2010
US7699879 Warsaw Orthopedic, Inc. Michael C. Sherman et al. Apr 2010
US7699890 Advanced Cardiovascular Systems, Inc. John Y. Yan Apr 2010
US7708548 Advanced Cardiovascular Systems, Inc. Daniel Brown et al. May 2010

Patent Family

Document NumberAssigneeInventorsIssue/Pub Date
CA2031529 STANFORD RES INST INT DANIELS ALMA U et al. Oct 1990
EP0422208 SRI INTERNATIONAL Alma U. DANIELS et al. Apr 1991
US5108755 SRI International Alma U. Daniels et al. Apr 1992