Filing Information

Inventor(s)	Alma U. Daniels · Jorge Heller ·
Assignee(s)	SRI International · University of Utah ·  View assignee updates
Attorney/Agent(s)	Morrison & Foerster ·
Primary Examiner	Thurman K. Page ·
Assistant Examiner	William E. Benston ·
Application Number	US7345034
Filing date	04/27/1989
Issue date	04/28/1992
Predicted expiration date	04/28/2009
U.S. Classifications	424/426  · 524/417  ·
International Classifications	A61F 200  ·
Kind Code	A
International Classifications	424426;78 ·

Patent Family

Abstract

A family of composites suitable for use as materials of construction for implantable medical devices is disclosed. In the most preferred embodiment, the substrate polymer is an ortho ester polymer formed by the reaction of a ketene acetal having a functionality of two or more with a polyol. Also in the most preferred embodiment, the reinforcement material in the composites is calcium-sodium metaphosphate ("CSM") fibers. In other embodiments, the composites may replace either (but not both) of the substrate or the reinforcement with materials of the art.

Independent Claims | See all claims (10)

1. 1. A reinforced bioerodible composite having a polymer substrate phase and dispersed therethrough a fiber reinforcement phase in a weight ratio of said polymer substrate phase to said fiber reinforcement phase of from 10:90 to 90:10, said polymer substrate phase being selected from the group consisting of poly(ortho ester), poly(levo lactic acid), poly(d/l lactic acid), poly(glycolic acid), the poly(ethyl ether) polydioxanone, L-lactide, epsilon-caprolactone, polycaprolactone, polyanhydrides, polypropylene fumarate, polyiminocarbonate, polyhydroxybutrate, polyhydroxyvalerate, poly(alkylene oxalate) and poly(ester-amide) and mixtures and copolymers thereof and said fiber reinforcement phase being selected from the group consisting of calcium-sodium metaphosphate, calcium phosphate, oriented poly(glycolic acid), oriented poly(lactic acid), sodium-calcium-aluminum polyphosphate, and mixtures thereof, subject to the proviso that when said polymer substrate phase is other than poly(ortho ester), said fiber reinforcement phase must include calcium-sodium metaphosphate and that when said fiber reinforcement phase is other than calcium-sodium metaphosphate, said polymer substrate phase must include poly(ortho ester).