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US5752974: Injectable or implantable biomaterials for filling or blocking lumens and voids of the body

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Filing Information

Inventor(s) Woonza M. Rhee · Richard A. Berg · George H. Chu · Frank A. DeLustro · Dan M. Jolivette · Kimberly A. McCullough ·
Assignee(s) Collagen Corporation ·
Attorney/Agent(s) Morrison & Foerster, LLP ·
Primary Examiner Jeffrey A. Schmidt ·
Application Number US8574050
Filing date 12/18/1995
Issue date 05/19/1998
Predicted expiration date 12/18/2015
U.S. Classifications 606/214  · 606/1  ·
International Classifications A61B 1700  ·
Kind CodeA
International Classifications 606213;214;215;216;1 ·
48 Claims, No Drawings


Abstract

Methods for completely or partially blocking, augmenting, sealing, or filling various biological lumens and voids within the body of a patient are disclosed. Lumens include arteries, veins, intestines, Fallopian tubes, and trachea. Voids include various lesions, fissures, diverticulae, cysts, fistulae, aneurysms, or other undesirable voids that may exist within a patient's body. In the most general method of the invention, an effective amount of a biomaterial is administered (e.g., via injection, catheter, or surgical implantation) into the lumen or void. Preferred biomaterial compositions for use in the present invention are disclosed.

Independent Claims | See all claims (48)

  1. 1. A method for completely or partially blocking, augmenting, sealing, or filling a lumen or void within the body comprising the steps of:a) providing a polymer and a hydrophilic crosslinking agent in suspension or solution to form an injectable or implantable biomaterial;b) injecting or implanting the biomaterial into a lumen or void within the body; andc) allowing the biomaterial to anchor to body tissue surrounding the lumen or void to totally or partially block or fill the lumen or void.
  2. 35. A method for completely or partially blocking, augmenting, sealing, or filling a biological lumen or void within the body of a patient comprising administering an effective amount of a biomaterial into the lumen or void;wherein the biomaterial is crosslinked using a mixture of hydrophilic and hydrophobic crosslinking agents.
  3. 46. A method for completely or partially blocking, augmenting, sealing, or filling a biological lumen or void within the body of a patient comprising administering an effective amount of a biomaterial into the lumen or void;wherein the biomaterial is a polymeric hydrogel which comprises a first synthetic polymer crosslinked using a second synthetic polymer, wherein the first synthetic polymer contains two or more nucleophilic groups, and the second synthetic polymer contains two or more electrophilic groups capable of forming covalent bonds with the nucleophilic groups on the first synthetic polymer.

References Cited

U.S. Patent Documents

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US4963146 Colla-Tec Incorporated Li Oct 1990
US5019087 American Biomaterials Corporation Nichols May 1991
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Foreign Patent Documents

Document NumberAssigneesInventorsIssue/Pub Date
EP0668081COLLAGEN CORPORATIONAug 1995
EP0697218COLLAGEN CORPORATIONFeb 1996
EP0713707COLLAGEN CORPORATIONMay 1996
EP0732109COLLAGEN CORPORATIONSep 1996
WO20WO9401483Jan 1994
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Other Publications

"Hysteroscopic Approaches for Tubal Closure," John J. Sciarra, Research Frontiers in Fertility Regulation, 1980, Chapter 26, pp. 270-286.
Longaker et al. "Maternal Outcome After Open Fetal Surgery: A Review of the First 17 Human Cases", J. Amer. Med Assoc., 265(6):737-741.

Referenced By

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