Join
today

Boliven PRO is more than just patent search

  • Build and save lists using the powerful Lists feature
  • Analyze and download your search results
  • Share patent search results with your clients

Patents »

US6214617: Centrifugal fermentation process

Share

Filing Information

Inventor(s) Heath H. Herman ·
Assignee(s) Kinetic Biosystems, Inc. ·
Attorney/Agent(s) Kilpatrick Stockton LLP ·
Primary Examiner David A. Redding ·
Application Number US9224645
Filing date 12/31/1998
Issue date 04/10/2001
Predicted expiration date 03/28/2015
U.S. Classifications 435/394  · 435/348  · 435/171  · 435/681  · 435/366  · 435/410  · 435/41  ·
International Classifications --
Kind CodeB1
International Classifications 4352851 · 4352861 · 4352865 · 4352867 · 4352891 · 435813 · 435 41 · 435 681 · 435 701 · 435 711 · 435171 · 435348 · 435366 · 435394 · 435410 ·
Related U.S. Application DataCROSS-REFERENCE TO RELATED APPLICATIONS
This application claims priority to U.S. Provisional Patent Applications Nos. 60/070,304; 60/070,251; 60/070,270; 60/070,133; 60/070,283; 60/070,078; 60/070,301 all filed Dec. 31, 1997, and this application is a continuation-in-part of U.S. patent application Ser. No. 09/115,109, filed Jul. 13, 1998, now U.S. Pat. No. 6,133,019, which is a continuation-in-part of U.S. patent application Ser. No. 08/784,718, filed Jan. 16, 1997, now U.S. Pat. No. 5,821,116, which is a division of U.S. patent application Ser. No. 08/412,289, filed Mar. 28, 1995, now U.S. Pat. No. 5,622,819.
16 Claims, 51 Drawings


Abstract

The present invention comprises a novel culture methods and devices in which living cells or subcellular biocatalysts are immobilized by the opposition of forces. The immobilized cells or biocatalysts may be attached to support complexes that add to the resultant vector forces.

Independent Claims | See all claims (16)

  1. 1. A method of producing secreted products from a biocatalyst comprising containing the biocatalyst in at least one chamber in a centrifugal force field wherein a continuous flow of a liquid acts to create a force which opposes the centrifugal force field and wherein a gravitational force contributes to the resultant vector summation of all forces acting on the biocatalyst, wherein the gravitational force, the centrifugal force and the opposing liquid force substantially immobilize the biocatalyst at a position in the chamber, the liquid is at hydraulic pressures greater than ambient pressure, and wherein no gaseous phase is present in said chamber, wherein the biocatalyst produces secreted products.
  2. 8. A method of removing contaminants from a liquid comprising containing a biocatalyst in at least one chamber in a centrifugal force field wherein a continuous flow of the liquid acts to create a force which opposes the centrifugal force field and wherein a gravitational force contributes to the resultant vector summation of all forces acting on the biocatalyst, wherein the gravitational force, the centrifugal force and the opposing liquid force substantially immobilize the biocatalyst at a position in the chamber, the liquid is at hydraulic pressures greater than ambient pressure, and wherein no gaseous phase is present in said chamber, wherein the biocatalyst removes contaminants from the liquid.

References Cited

U.S. Patent Documents

Document NumberAssigneesInventorsIssue/Pub Date
US2616619 MACLEOD NORMAN A MacLeod Nov 1952
US3450598 FLOW LAB Welsh et al. Jun 1969
US3580840 LITTON SYSTEMS INC Uridil May 1971
US3717551 BIZZINI B Bizzini et al. Feb 1973
US3753731 CHRIST C Christ Aug 1973
US3821087 DEDRICK R Knazek et al. Jun 1974
US3843454 ABBOTT LAB Weiss Oct 1974
US3865695 AGRICOLE DE MYCELIUM DU CENTRE Massier Feb 1975
US3871961 GIANESSI MATILDE Gianessi Mar 1975
US3883393 US HEALTH EDUCATION & WELFARE Knazek et al. May 1975
US3928142 Smith Dec 1975
US3941662 Max-Planck-Gesellschaft zur Forderung der Wissenschaften e.V. Munder et al. Mar 1976
US3948732 Instrumentation Laboratory, Inc. Haddad et al. Apr 1976
US3968035 Eli Lilly and Company Howe Jul 1976
US3997396 Monsanto Company Delente Dec 1976
US4001090 Societe d'Assistance Technique pour Produits Nestle S.A. Kalina Jan 1977
US4036693 Massachusetts Institute of Technology Levine et al. Jul 1977
US4059485 Monsanto Company Tolbert et al. Nov 1977
US4087327 Monsanto Company Feder et al. May 1978
US4113173 Baxter Travenol Laboratories, Inc. Lolachi Sep 1978
US4114802 Baxter Travenol Laboratories, Inc. Brown Sep 1978
US4148689 Sanraku-Ocean Co., Ltd. Hino et al. Apr 1979
US4166768 Monsanto Company Tolbert et al. Sep 1979
US4169010 Phillips Petroleum Company Marwil Sep 1979
US4178209 Monsanto Company Tolbert et al. Dec 1979
US4184916 Monsanto Company Tolbert et al. Jan 1980
US4184922 The Government of the United States Knazek et al. Jan 1980
US4189534 Massachusetts Institute of Technology Levine et al. Feb 1980
US4195131 PAPAS GARY R Papas Mar 1980
US4201845 Monsanto Company Feder et al. May 1980
US4203801 Burroughs Wellcome Co. Telling et al. May 1980
US4220725 United States of America Knazek et al. Sep 1980
US4225671 Battelle-Institut e.V. Puchinger et al. Sep 1980
US4237033 Merck & Co., Inc. Scattergood Dec 1980
US4237218 Bio-Rad Laboratories, Inc. Monthony et al. Dec 1980
US4266032 Monsanto Company Miller et al. May 1981
US4279753 Arco Environmental Company Nielson et al. Jul 1981
US4289854 Monsanto Company Tolbert et al. Sep 1981
US4293654 Massachusetts Institute of Technology Levine et al. Oct 1981
US4296882 Terumo Corporation Kobayashi Oct 1981
US4308351 LEIGHTON JOSEPH Leighton et al. Dec 1981
US4335215 Monsanto Company Tolbert et al. Jun 1982
US4372484 Gambro AB Larsson et al. Feb 1983
US4391912 Asahi Kasei Kogyo Kabushiki Kaisha Yoshida et al. Jul 1983
US4413058 ARCURI EDWARD J Arcuri et al. Nov 1983
US4425112 The United States of America as represented by the Department of Health and Human Services Ito Jan 1984
US4442206 Stanford University Michaels et al. Apr 1984
US4463019 Kikkoman Corporation Okuhara et al. Jul 1984
US4537860 Monsanto Company Tolbert et al. Aug 1985
US4546085 A/S Nunc Johannson et al. Oct 1985
US4557504 KUHNS ROGER J Kuhns Dec 1985
US4603109 Norton Company Lillo Jul 1986
US4661455 Dorr-Oliver Incorporated Hubbard Apr 1987
US4683062 Ceskoslovenska akademie ved Krovák et al. Jul 1987
US4693983 National Research Development Corporation Davies et al. Sep 1987
US4722902 Endotronics, Inc. Harm et al. Feb 1988
US4734372 Brown University Research Foundation Rotman Mar 1988
US4748124 E. I. Du Pont de Nemours and Company Vogler May 1988
US4764471 Nabisco Brands, Inc. Ripka Aug 1988
US4774187 S Diessel Gmbh & Co. Lehmann Sep 1988
US4804628 Endotronics, Inc. Cracauer et al. Feb 1989
US4833083 Sepragen Corporation Saxena May 1989
US4833089 Shimadzu Corporation Kojima et al. May 1989
US4837390 Keyes Offshore, Inc. Reneau Jun 1989
US4839292 CREMONESE JOSEPH G Cremonese Jun 1989
US4851354 Trustees of the University of Pennsylvania Winston et al. Jul 1989
US4874358 Utah Bioreseach, Inc. Brimhall et al. Oct 1989
US4894342 C. D. Medical, Inc. Guinn et al. Jan 1990
US4895806 Millipore Ireland B.V. Le et al. Jan 1990
US4897359 Bio-Response, Inc. Oakley et al. Jan 1990
US4898718 Cipan-Companhia Industrial Produtora De Antibioticos, S. A. Cardoso Feb 1990
US4908319 SMYCZEK PETER J Smyczek et al. Mar 1990
US4931401 La Societe de Recherche Snc Inc. Safi Jun 1990
US4937196 Brunswick Corporation Wrasidlo et al. Jun 1990
US4939087* Washington State University Research Foundation, Inc. Van Wie et al. Jul 1990
US5151368 Technical Research Associates, Inc. Brimhall et al. Sep 1992
US5248613 ROUBICEK RUDOLF V Roubicek Sep 1993
US5272075 Large Scale Biology Corporation Anderson et al. Dec 1993
US5622819* Kinetic Biosystems, Inc. Herman Apr 1997
US5821116* Kinetic Biosystems, Inc. Herman Oct 1998

Foreign Patent Documents

Document NumberAssigneesInventorsIssue/Pub Date
JP54114474Nov 1979
JP62100279SANKI ENG KKMay 1987
* cited by examiner

Other Publications

Lindahl, P.E., “Principle of a Counter-streaming Centrifuge for the Separation of Particles of Different Sizes”,
Morton, H., “A Survey of Commercially Available Tissue Culture Media”, In Vitro, vol. 6, No. 2 (1970).
Sanderson et al., “Cell Separations by Counterflow Centrifugation”,
Clark et al., “Optimizing Culture Conditions for the Production of Animal Cells in Microcarrier Culture”,
, vol. 8, No. 22, p. 16 (Nov. 14, 1994).

Patent Family

The current document is not in a family.