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US6395226: Alkoxysilane/alkysilane copolymer coating of medical devices

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Filing Information

Inventor(s) Sean D. Plunkett ·
Assignee(s) Medtronic, Inc. ·
Attorney/Agent(s) Thomas G. Berry · Stephen W. Bauer · Daniel W. Latham ·
Primary Examiner Angela D. Sykes ·
Assistant Examiner P M Bianco ·
Application Number US9286804
Filing date 04/06/1999
Issue date 05/28/2002
Predicted expiration date 04/06/2019
U.S. Classifications 422/48  · 210/645  · 604/609  · 604/614  · 422/157  · 96/10  · 261/DIG.28  · 422/44  ·
International Classifications --
Kind CodeB1
International Classifications 210645- 46 · 210650- 54 · 424422-426 · 96 7- 11 · 428446- 47 · 442152- 53 · 4352971-2974 · 604 401 · 604 609 · 604 614 · 422 44 · 422 45 · 422 48 · 210696 · 210767 · 210782 · 210348 · 128898 · 424400 · 424486 · 96 4 · 96155 · 96218 · 96234 · 96235 · 96243 · 96296 · 96299 · 428391 · 428378 · 442157 · 522 91 · 522 99 · 516906 · 556400 · 556462 · 4352891 · 261296 · 261 19 · 261 28 · 261 29 · 261 75 · 261DIG 28 ·
11 Claims, 11 Drawings


Abstract

A coating for microporous hollow fiber membrane blood oxygenators increases the resistance of the fibers to passage of blood plasma through the micropores. The coating comprises alkoxysilane/alkylsilane copolymer, preferably aminoalkylsiloxane.

Independent Claims | See all claims (11)

  1. 1. A medical device comprising a hollow fiber membrane comprising micropores and a siloxane copolymer coating on the hollow fiber membrane that does not cover or fill the micropores, wherein the siloxane copolymer coating presents a surface near the micropores that reduces the migration of plasma across the micropores in the membrane.
  2. 5. A medical device comprising a microporous hollow fiber membrane, in which the membrane is coated with an alkoxysilane/alkylsilane copolymer coating by a method comprising the steps of: formulating a liquid alkoxysilane/alkylsilane copolymer coating; and coating the device to create a thin film of silicone on the microporous fiber membrane to the extent sufficient to reduce migration of plasma across micropores in the membrane but neither covering or filling any micropores, and curing the copolymer on the device.
  3. 6. A medical device comprising a microporous hollow fiber membrane having a coating applied to the membrane according to a method comprising the steps of: formulating a liquid alkoxysilane/alkylsilane copolymer coating; and coating the device to create a thin film of silicone on the microporous fiber membrane but neither covering or filling any micropores, and curing the copolymer on the device.

References Cited

U.S. Patent Documents

Document NumberAssigneesInventorsIssue/Pub Date
US3846359* RHONE POULENC SA Rostaing Nov 1974
US4049873* Imperial Chemical Industries Limited Creasey et al. Sep 1977
US4906465* Massachusetts Institute of Technology Chaikof et al. Mar 1990
US4909989 Terumo Kabushiki Kaisha (Terumo Corporation) Fukazawa et al. Mar 1990
US4923679* Terumo Kabushiki Kaisha Fukasawa et al. May 1990
US5643681 Cobe Laboratories, Inc. Voohees et al. Jul 1997
US5702823 COBE Laboratories, Inc. Forrestal et al. Dec 1997
US5738902 COBE Laboratories, Inc. Forrestal et al. Apr 1998
US6024918* Medtronic, Inc. Hendriks et al. Feb 2000
US6136938* Dow Corning Corporation Halloran Oct 2000

Foreign Patent Documents

Document NumberAssigneesInventorsIssue/Pub Date
EP0353687*DOW CORNING CORPORATIONFeb 1990
WO199115952Oct 1991
* cited by examiner

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