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US6569442: Preparation of polymer foam having gelled sol coating for intervertebral disc reformation

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Filing Information

Inventor(s) Jean Chin Chin Gan · Paul Ducheyne · Edward Vresilovic · Irving Shapiro ·
Assignee(s) The Trustees of the University of Pennsylvania ·
Attorney/Agent(s) Woodcock Washburn LLP ·
Primary Examiner David M. Naff ·
Application Number US9833284
Filing date 04/12/2001
Issue date 05/27/2003
Prior Publication Data
Predicted expiration date 08/08/2016
U.S. Classifications 424/426  · 435/325  · 424/937  · 435/176  · 435/177  · 435/180  · 424/423  · 435/381  · 435/395  · 435/397  · 623/171.6  · 128/898  ·
International Classifications --
Kind CodeB2
International Classifications 435174 · 435176 · 435177 · 435180 · 435325 · 435378 · 435381 · 435395 · 435397 · 424 937 · 424423 · 424426 · 128898 · 623 1716 ·
Related U.S. Application DataThis Application is a division of application Ser. No. 09/314,511, filed May 19, 1999, now U.S. Pat. No. 6,240,926, which is a division of application Ser. No. 08/694,191, filed Aug. 8, 1996, now U.S. Pat. No. 5,964,807.
9 Claims, 1 Drawings


Abstract

Methods and materials are provided for reforming degenerated intervertebral discs of the spine of a vertebrate and in particular the spine of a human. Tissue is evacuated from the nucleus pulposus portion of a degenerated intervertebral disc space, and a biodegradable substrate containing isolated intervertebral disc cells is implanted in the evacuated space for reformation of intervertebral disc tissue. Intervertebral disc cells are provided by digesting intervertebral disc tissue with collagenase and incubating the cells in a medium supplemented with hyaluronidase. The substrate may be bioactive so as to enhance cell function. Substrates include bioactive glass granules, polymer foams and the polymer foams coated with a bioactive gel material produced by a sol-gel process. A polymer foam is dipped into a sol resulting from combining a metal alkoxide precursor with water and acid, residual sol is evacuated from pores of the foam, and remaining sol contained by the foam is allowed to gel. The polymer of the foam may be poly(D,L-lactide-co-glycolide). A preferred bioactive gel material contains 70% SiO2, 25% CaO and 5% P2O5.

Independent Claims | See all claims (9)

  1. 1. A method of making a bioactive substrate comprising a porous polymer foam coated with a bioactive gel material, wherein the bioactive gel material is produced by a sol-gel process comprising combining a metal alkoxide precursor with water and an acid catalyst to produce a sol and allowing the sol to gel, comprising the steps of: dipping the porous polymer foam into the sol whereby pores of the polymer foam are filled with the sol, evacuating residual sol from the pores of the polymer foam, and allowing remaining sol contained by the porous polymer foam to gel to obtain the porous polymer foam coated with the bioactive gel material, wherein the bioactive gel material penetrates the pores of the polymer foam and at least about 50% of the surface of the polymer foam, which includes the pores, is coated with the bioactive gel material.

References Cited

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Foreign Patent Documents

Document NumberAssigneesInventorsIssue/Pub Date
WO199805274Feb 1998
* cited by examiner

Other Publications

Baldick, H. et al., “Bioactive Glass Increases Alkaline Phosphatase Activity in Rat Marrow Stromal Cells In Vitro,”
El-Ghannam et al., “Bioactive material template for in vitro synthesis of bone,”
Healy et al., “Hydration and preferential molecular adsorption on titanium in vitro,”
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Referenced By

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