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US6716967: Rupestris stem pitting associated virus nucleic acids, proteins, and their uses

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Filing Information

Inventor(s) Dennis Gonsalves · Baozhong Meng ·
Assignee(s) Cornell Research Foundation, Inc. ·
Attorney/Agent(s) Clark & Elbing, LLP ·
Primary Examiner James Housel ·
Assistant Examiner Bao Qun Li ·
Application Number US9568189
Filing date 05/09/2000
Issue date 04/06/2004
Predicted expiration date 05/19/2018
U.S. Classifications 530/388.1  · 435/6  · 424/139.1  · 424/141.1  · 424/801  · 435/5  · 530/391.5  · 435/91  · 435/71  · 536/221  · 536/243.2  · 530/389.1  ·
International Classifications --
Kind CodeB1
International Classifications 436 5 · 436 6 · 436 912 · 436 71 · 536 221 · 536 2432 · 5303881 · 5303891 · 5303915 · 4241441 · 424801 · 4241391 ·
Related U.S. Application DataThis application is a continuation of application Ser. No. 09/081,320, filed May 19, 1998, now U.S. Pat. No. 6,093,544, which claims the benefit of U.S. Provisional Patent applications Ser. Nos. 60/047,147, filed May 20, 1997, and 60/069,902, filed Dec. 17, 1997. This work was supported by the U.S. Department of Agriculture Clonal Repository—Geneva, Grant Nos. 58-2349-9-01 and 58-2349-9 and U.S. Department of Agriculture Cooperative Agreement Grant Nos. 58-1908-4-023, 58-3615-5-036, and 58-3615-7-060. The U.S. Government may have certain rights in the invention.
40 Claims, 16 Drawings


Abstract

This invention relates to purified monoclonal antibodies that specifically bind to a Rupestris stem pitting associated virus coat protein or coat protein polypeptide, and methods of detecting a Rupestris stem pitting associated virus.

Independent Claims | See all claims (40)

  1. 1. A purified monoclonal antibody or binding portion thereof that specifically binds to a Rupestris stem pitting associated virus coat protein or coat protein polypeptide, wherein said coat protein or coat protein polypeptide is selected from the group consisting of: (a) a coat protein or coat protein polypeptide encoded by the nucleic acid molecule of SEQ ID NO:10, SEQ ID NO-21, or SEQ ID NO:32; (b) a coat protein or coat protein polypeptide having the amino acid sequence of SEQ ID NO:11; (c) a coat protein or coat protein polypeptide having the amino acid sequence of SEQ ID NO:22; and (d) a coat protein or coat protein polypeptide having the amino acid sequence of SEQ ID NO:33.

References Cited

U.S. Patent Documents

Document NumberAssigneesInventorsIssue/Pub Date
US4358535 Board of Regents of the University of Washington Falkow et al. Nov 1982
US4480040 The United States of America as represented by the Secretary of Agriculture Owens et al. Oct 1984
US5043272 Life Technologies, Incorporated Hartley Aug 1991
US5104792 The United States of America as represented by the Department of Health and Human Services Silver et al. Apr 1992
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Foreign Patent Documents

Document NumberAssigneesInventorsIssue/Pub Date
EP0571911Becton Dickinson and CompanyDec 1993
WO199621034Jul 1996
WO199737037Oct 1997

Other Publications

Ling et al. Arch Virol. 1997, vol. 142, pp. 1101-1116.*
Coding et al. Monoclonal Antibodies Principles and Practice 1996, Third edition. Haicourt Race and Company Publishers, pp. 62-62, pp. 141-180, and pp. 465-475.*
Minafra et al., “Detection of an unusual RNA in grapevines indexing positive for rupestris stem pitting,”
Stobbs et al., “Survey for rupestris stem-pitting and corky bark diseases of grapevine in the Niagara peninsula, Ontario,”
Meng et al., “Nucleotide sequence and genomic organization of grapevine Rupestris stem pitting-associated virus and its detection by RT-PCR,”
Zhang et al., “Nucleotide Sequence and RT-PCR Detection of a Virus Associated with Grapevine Rupestris Stem-Pitting Disease,”
GenBank Accession AF026278 “Grapevine Rupestris stem pitting associated virus,” (submitted Sep. 22, 1997).
GenBank Accession AF057136 “Rupestris stem pitting associated virus,” (submitted Apr. 3, 1998).
Azzam et al., “Detection of dsRNA in Grapevines Showing Symptoms of Rupestris Stem Pitting Disease and the Variabilities Encountered,”
Azzam et al., “Detection of dsRNA from Cleistothecia and Conidia of the Grape Powdery Mildew Pathogen,
Beachy et al., “Coat Protein-Mediated Resistance Against Virus Infection,”
Credi, “Characterization of Grapevine Rugose Wood Disease Sources of Italy,”
Krastanova et al., “Transformation of Grapevine Rootstocks with the Coat Protein Gene of Grapevine Fanleaf Nepoviurus,”
Le Gall et al., “
Meng et al., “Nucleotide Sequence and Genomic Organization of Grapevine Rupestris Stem Pitting Associated Virus and its Detection by RT-PCR,”
Meng et al., Rupestris Stem Pitting of Grapevines: Nucleotide Sequence, RT-PCR Detection, and Viral Origin of Associated DsRNA, 12
Meng et al., “Nucleotide Sequence and Genome Structure of Grapevine Rupestris Stem Pitting Associated Virus-1 Reveal Similarities to Stem Pitting Virus,”
Monette et al., “The Use of In Vitro Cultures in the Investigation of Grapevine Virus-like Diseases,”
Monette et al., “Double-Stranded RNA from Rupestris Stem Pitting-Affected Grapevines,”
Salati et al., “Detection of Grapevine Viruses Associated with Leafroll, Corky Bark, and Rupestris Stem Pitting Using F(ab)
Schell et al., “Transformation of ‘Nova’ Tangelo With the coat Protein Gene of Citrus Tristeza Closterovirus,”
Wetzel et al. “A Highly Sensitive Immunocapture Polymerase Chain Reaction Method for Plum Pox Potyvirus Detection,”
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Referenced By

The current document is not referenced by other documents.

Patent Family

Document NumberAssigneeInventorsIssue/Pub Date
US6093544 Cornell Research Foundation, Inc. Dennis Gonsalves et al. Jul 2000
US6716967 Cornell Research Foundation, Inc. Dennis Gonsalves et al. Apr 2004