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US6855533: Structure-based designed herbicide resistant products


Filing Information

Inventor(s) Genichi Kakefuda · Karl-Heinz Ott · Jae-Gyu Kwagh · Gerald W. Stockton ·
Assignee(s) BASF Corporation ·
Attorney/Agent(s) Sutherland Asbill & Brennan LLP ·
Primary Examiner Nashaat T. Nashed ·
Application Number US10407339
Filing date 04/04/2003
Issue date 02/15/2005
Prior Publication Data
Predicted expiration date 04/20/2015
U.S. Classifications 435/232  · 536/232  ·
International Classifications --
Kind CodeB2
International Classifications 435232 · 435183 · 435189 · 536 232 · 536 231 ·
Related U.S. Application DataThis application is a continuation of U.S. Ser. No. 09/367,512 filed Aug. 17, 2000 now U.S. Pat. No. 6,576,455, which is a continuation of PCT/US96/05782 filed Apr. 19, 1996, and a divisional of U.S. Ser. No. 08/455,355 filed on May 31, 1995, issued as U.S. Pat. No. 5,928,937, which is a continuation-in-part of Ser. No. 08/426,125 filed Apr. 20, 1995, issued as U.S Pat. No. 5,853,973.
5 Claims, 27 Drawings


Disclosed herein are structure-based modelling methods for the preparation of acetohydroxy acid synthase (AHAS) variants, including those that exhibit selectively increased resistance to herbicides such as imidazoline herbicides and AHAS inhibiting herbicides. The invention encompasses isolated DNAs encoding such variants, vectors that include the DNAs, and methods for producing the variant polypeptides and herbicide resistant plants containing specific AHAS gene mutations. Methods for weed control in crops are also provided.

Independent Claims | See all claims (5)

  1. 1. A variant plant acetohydroxy acid synthase (AHAS) protein comprising at least one mutation at an amino acid residue corresponding to amino acid G583 of SEQ ID NO: 1, wherein said variant plant AHAS protein is more resistant to an herbicide than the wild-type plant AHAS protein.

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Referenced By

The current document is not referenced by other documents.

Patent Family

Document NumberAssigneeInventorsIssue/Pub Date
US20030180929 American Home Products Corporation Karl-Heinz Ott et al. Sep 2003
US6855533 BASF Corporation Genichi Kakefuda et al. Feb 2005