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US6923964: Active immunization of AScr for prion disorders


Filing Information

Inventor(s) Dale B. Schenk ·
Assignee(s) Neuralab Limited ·
Attorney/Agent(s) Townsend and Townsend and Crew LLP ·
Primary Examiner Elizabeth Kemmerer ·
Assistant Examiner Christopher James Nichols ·
Application Number US9585817
Filing date 06/01/2000
Issue date 08/02/2005
Predicted expiration date 04/16/2020
Patent term adjustment 503
U.S. Classifications 424/185.1  · 514/12  · 514/4  · 514/2  ·
International Classifications --
Kind CodeB1
International Classifications 4241851 · 514 2 · 514 4 · 514 12 · 530300 · 530350 ·
Related U.S. Application DataThis application claims the benefit under 35 U.S.C. 119(e) of U.S. Application No. 60/137,010, filed Jun. 1, 1999, which is hereby incorporated herein in its entirety. This application is also a continuation-in-part of U.S. application Ser. No. 09/580,015, filed May 26, 2000, now abandoned, which is a continuation-in-part of U.S. application Ser. No. 09/322,289, filed May 28, 1999, which is a continuation in part of U.S. Ser. No. 09/201,430, filed Nov. 30, 1998, now U.S. Pat. No. 6,787,523 which claims the benefit under 35 U.S.C. 119(e) of U.S. Application No. 60/080,970, filed Apr. 7, 1998, and U.S. Application 60/067,740, filed Dec. 2, 1997.
10 Claims, 16 Drawings


Disclosed are pharmaceutical compositions and methods for preventing or treating a number of amyloid diseases, including Alzheimer's disease, prion diseases, familial amyloid neuropathies and the like. The pharmaceutical compositions include immunologically reactive amounts of amyloid fibril components, particularly fibril-forming peptides or proteins. Also disclosed are therapeutic compositions and methods which use immune reagents that react with such fibril components.

Independent Claims | See all claims (10)

  1. 1. A method of treating a prior disorder associated with AScr in a mammalian subject suffering from the disorder, comprising administering to the subject a dosage of an agent effective to produce an immune response comprising antibodies against the agent and an adjuvant that augments the immune response to the agent, and thereby treating the disorder, wherein the agent is PrR or AScr.

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