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US6933331: Nanotechnology for drug delivery, contrast agents and biomedical implants

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Filing Information

Inventor(s) Tapesh Yadav · Clayton Kostelecky ·
Assignee(s) NanoProducts Corporation ·
Attorney/Agent(s) Stuart T. Langley · Hogan & Hartson L.L.P. ·
Primary Examiner Katarzyna Wyrozebski ·
Application Number US9790036
Filing date 02/20/2001
Issue date 08/23/2005
Prior Publication Data
Predicted expiration date 05/22/2018
U.S. Classifications 523/210  · 524/406  · 523/200  · 523/375  · 524/403  · 523/137  · 524/408  · 524/434  · 524/435  · 524/436  · 523/105  ·
International Classifications --
Kind CodeB2
International Classifications 524435 · 524403 · 524406 · 524408 · 524434 · 524436 · 523210 · 523105 · 523137 · 523200 · 523375 · 424 129 · 424 133 · 424 161 · 424 165 · 424 9322 · 424 9323 · 424 9411 · 424408 · 424417 · 424421 ·
Related U.S. Application DataRELATED APPLICATIONS
This application is a continuation of Ser. No. 09/083,893 now U.S. Pat. No. 6,228,904 filed on May 22, 1998 which is incorporated herein by reference and which claims the benefit of U.S. Provisional applications 60/049,077 filed on Jun. 5, 1997, 60/069,936 filed on Dec. 17, 1997, and 60/079,225 filed on Mar. 24, 1998 and which is a continuation-in-part of U.S. patent application Ser. No. 08/739,257, filed Oct. 30, 1996, now U.S. Pat. No. 5,905,000, titled NANOSTRUCTURED ION CONDUCTING SOLID ELECTROLYTES, which is a continuation-in-part of U.S. Ser. No. 08/730,661, filed Oct. 11, 1996, now U.S. Pat. No. 5,952,040 titled “PASSIVE ELECTRONIC COMPONENTS FROM NANO-PRECISION ENGINEERED MATERIALS” which is a continuation-in-part of U.S. Ser. No. 08/706,819, filed Sep. 3, 1996, now U.S. Pat. No. 5,851,507 titled “INTEGRATED THERMAL PROCESS FOR THE CONTINUOUS SYNTHESIS OF NANOSCALE POWDERS” and U.S. Ser. No. 08/707,341, filed Sep. 3, 1996, now U.S. Pat. No. 5,788,738 titled “METHOD OF PRODUCING NANOSCALE POWDERS BY QUENCHING OF VAPORS”.
28 Claims, 3 Drawings


Abstract

A nanocomposite structure comprising a nanostructured filler or carrier intimately mixed with a matrix, and methods of making such a structure. The nanostructured filler has a domain size sufficiently small to alter an electrical, magnetic, optical, electrochemical, chemical, thermal, biomedical, or tribological property of either filler or composite by at least 20%.

Independent Claims | See all claims (28)

  1. 1. A biomedical material for administration in a human or animal comprising: nanostructured ceramic powders whose surface has been reacted with a precursor; a solid matrix; wherein the nanostructured ceramic powders have been embedded in the solid matrix; and wherein the nanostructured ceramic powders have a domain size smaller than a capillary blood vessel.
  2. 11. A biomedical material for administration in a human or animal comprising; nanostructured ceramic powders whose surface has been reacted with a precursor; a solid matrix; wherein the nanostructured ceramic powders have been embedded in the solid matrix; wherein the nanostructured ceramic powders have a domain size smaller than a capillary blood vessel; and a drug, wherein the nanostructured ceramic powders function as a carrier for the drug.
  3. 12. A biomedical material for administration in a human or animal comprising: nanostructured ceramic powders whose surface has been reacted with a precursor; a solid matrix; wherein the nanostructured ceramic powders have been embedded in the solid matrix; wherein the nanostructured ceramic powders have a domain size smaller than a capillary blood vessel; and a coating formed on the nanostructured ceramic powders wherein the nanostructured powders are water-soluble and the coated material is water-insoluble.
  4. 13. A biomedical material for administration in a human or animal comprising: nanostructured ceramic powders whose surface has been reacted with a precursor; a solid matrix; wherein the nanostructured ceramic powders have been embedded in the solid matrix; wherein the nanostructured ceramic powders have a domain size smaller than a capillary blood vessel; and wherein the material delivers a time-release drug.
  5. 14. A biomedical material for administration in a human or animal comprising: nanostructured ceramic powders whose surface has been reacted with a precursor; a solid matrix; wherein the nanostructured ceramic powders have been embedded in the solid matrix; wherein the nanostructured powders have a domain size smaller than a capillary blood vessel; and wherein the nanostructured ceramic powders are responsive to an externally applied magnetic field so as to preferentially gather and function in locations having an applied magnetic field.
  6. 16. A biomedical material for administration in a human or animal comprising: nanostructured ceramic powders whose surface has been reacted with a precursor; a solid matrix; wherein the nanostructured ceramic powders have been embedded in the solid matrix; wherein the nanostructured ceramic powders have a domain size smaller than a capillary blood vessel; and wherein the powders comprise a marker.
  7. 19. A biomedical material for administration in a human or animal comprising: a filler of powders whose surfaces have been reacted with a precursor; a solid matrix; wherein the filler of powders is embedded in the solid matrix; wherein the filler powders are nanostructured; the loading of the filler is less than 95 volume percent; and wherein the filler composition comprises a ceramic and the composition is administered in a human or animal.
  8. 20. A material for biological application comprising: nanostructured inorganic powders having a domain size smaller than 100 nm; wherein the surface of the nanostructured inorganic powders has been reacted with a precursor to form a coating; wherein the coating comprises a polymer and the coated nanostructured inorganic powders serve as a time-release delivery of a drug.
  9. 21. A biomedical material for administration in a human or animal comprising: nanostructured metallic powders whose surfaces have been reacted with a precursor; a solid matrix; wherein the nanostructured metallic powders are embedded in the solid matrix; a solid composite comprising a matrix and nanostructured metallic powders; and wherein the nanostructured metallic powders have a domain size smaller than a capillary blood vessel.
  10. 24. A nanostructured material comprising: water-soluble nanostructured inorganic powders having a domain size smaller than 100 nm; wherein the surfaces of the nanostructured inorganic powders have been reacted with a precursor; wherein the nanostructured inorganic powders become water-insoluble after the nanostructured inorganic powders have been reacted with the precursor.
  11. 25. A nanostructured material comprising: water-insoluble nanostructured inorganic powders having a domain size smaller than 100 nm; wherein the surfaces of the nanostructured inorganic powders have been reacted with a precursor; a coating on the powders, wherein the coating comprises a metallic species and the coated powders are a vehicle to deliver biologically active species; wherein the nanostructured inorganic powders becomes water-soluble after the nanostructured inorganic powders have been reacted with the precursor.

References Cited

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Referenced By

Document NumberAssigneeInventorsIssue/Pub Date
US7388042 PPG Industries Ohio, Inc. Tapesh Yadav et al. Jun 2008
US7498063 Regents of the University of Minnesota David Y. H. Pui et al. Mar 2009
US7247338 Regents of the University of Minnesota David Y. H. Pui et al. Jul 2007
US7282194 GP Medical, Inc. Hsing-Wen Sung et al. Oct 2007
US7279322 Regents of the University of Minnesota David Y. H. Pui et al. Oct 2007
US7341757 NanoProducts Corporation Tapesh Yadav Mar 2008
US7905942 SDCmaterials, Inc. Fredrick P. Layman Mar 2011
US7897127 SDCmaterials, Inc. Frederick P. Layman et al. Mar 2011
US7678419 SDC Materials, Inc. Rob Kevwitch et al. Mar 2010
US7708974 PPG Industries Ohio, Inc. Tapesh Yadav May 2010
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US8051724 SDCmaterials, Inc. Frederick P. Layman et al. Nov 2011
US8094247 Cambrios Technologies Corporation Pierre-Marc Allemand et al. Jan 2012
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Patent Family

Document NumberAssigneeInventorsIssue/Pub Date
US20020014182 Clayton Kostelecky et al. Feb 2002
US6933331 NanoProducts Corporation Tapesh Yadav et al. Aug 2005