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US7045362: Device and method for detecting organic molecules in a test substance

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Filing Information

Inventor(s) Gerhard Hartwich · Harald Lossau ·
Assignee(s) Harald Lossau ·
Attorney/Agent(s) Squire, Sanders & Dempsey ·
Primary Examiner Jeffrey R. Snay ·
Application Number US10220235
Filing date 02/15/2001
PCT 371 date 08/27/2002
Issue date 05/16/2006
Prior Publication Data
Predicted expiration date 10/30/2022
Patent term adjustment 622
U.S. Classifications 436/172  · 436/820.8  · 436/422  ·
International Classifications G01N2164  ·
Kind CodeB2
PCT Application Number WO20PCTDE0100571 - 02/15/2001
PCT Publication Number WO200169210 - 09/20/2001
Foreign Priority DE10013254 - 03/17/2000 ·
27 Claims, 10 Drawings


Abstract

An apparatus for detecting organic molecules, especially biomolecules and polymers, in a probe substance, comprises a test system (300) comprising an array of test sites (T) to which the probe substance can be supplied, each test site having specific probe molecules (320), an illumination system (100) for optically illuminating a sub-array of test sites (T), and a detection system (400) for identifying those test sites (T) whose probe molecules (320) interact with the organic molecules (350) to be detected, the illumination system (100) comprising an array of independently addressable illumination sources (B) arranged such that to each test site (T) of the sub-array is assigned at least one illumination source (B) that illuminates substantially only it.

Independent Claims | See all claims (27)

  1. 1. A method for detecting organic molecules in a probe substance, with the following process steps: providing a test system (300) comprising an array of test sites (T), each test site having specific probe molecules (320); providing an illumination system (100) for optically illuminating the array of test sites, the illumination system comprising an array of independently addressable illumination sources (B) that are arranged such that to each test site (T) of a sub-array of the test system (300) is assigned at least one illumination source that illuminates substantially only it; supplying the probe substance to the test system (300); illuminating the test sites (T) by addressing the respective illumination sources (B) assigned to them, according to a preselected pattern wherein, in at least one step, multiple test sites are illuminated simultaneously; reading out all illuminated test sites together after each step of the illumination pattern with a detection system (400) having no spatial resolution; and identifying those test sites (T) whose probe molecules (320) interact with the organic molecules (350) to be detected.

References Cited

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Foreign Patent Documents

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* cited by examiner