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US7179650: Compositions and uses for a novel cell-death-protecting protein


Filing Information

Inventor(s) Edward T. H. Yeh ·
Assignee(s) Board of Regents, the University of Texas System ·
Attorney/Agent(s) Fulbright & Jaworski LLP ·
Primary Examiner Anne M. Wehbe′ ·
Application Number US9484964
Filing date 01/18/2000
Issue date 02/20/2007
Predicted expiration date 11/04/2017
U.S. Classifications 435/455  · 435/320.1  · 435/325  ·
International Classifications C12N1563  · C12N1574  · C12N500  ·
Kind CodeB1
Related U.S. Application Data1.0 BACKGROUND OF THE INVENTION
This application is a divisional of U.S. patent application Ser. No. 08/964,162, now abandoned, filed on Nov. 4, 1997, which is a continuing application of U.S. Provisional Application Ser. No. 60/030,302, filed Nov. 5, 1996, the content of which is specifically incorporated herein by reference in its entirety.
6 Claims, 21 Drawings


Disclosed are compositions comprising a novel cell-death protecting protein, sentrin-1, and the gene which encodes it. Also disclosed are methods of making and using sentrin polypeptides and nucleic acid segments in various diagnostic and pharmaceutical applications. In a preferred embodiment, overexpression of sentrin-1 confers protection against both anti-Fas/APO-1 and TNF-induced apoptosis.

Independent Claims | See all claims (6)

  1. 1. A method of inhibiting apoptosis in a cell comprising providing, in vitro, the cell with a nucleic acid segment encoding a polypeptide comprising SEQ ID NO:2, wherein a Fas and/or TNFR1 mediated apoptosis pathway is inhibited in the cell.
  2. 4. A method of inhibiting apoptosis in a cell comprising providing, in vitro, the cell with a nucleic acid segment comprising at least SEQ ID NO:1, wherein a Fas and/or TNFR1 mediated apoptosis pathway is inhibited in the cell.

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Other Publications

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Referenced By

The current document is not referenced by other documents.