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US7235233: Serotype 5 adenoviral vectors with chimeric fibers for gene delivery in skeletal muscle cells or myoblasts


Filing Information

Inventor(s) Menzo Jans Emco Havenga · Abraham Bout ·
Assignee(s) Crucell Holland B.V. ·
Attorney/Agent(s) TraskBritt ·
Primary Examiner Joseph Woitach ·
Assistant Examiner Robert M. Kelly ·
Application Number US10381857
Filing date 09/25/2001
PCT 371 date 08/13/2003
Issue date 06/26/2007
Prior Publication Data
Predicted expiration date 01/14/2022
Patent term adjustment 111
U.S. Classifications 424/931  · 514/44  · 435/325  · 424/932.1  ·
International Classifications A01N4304  · A01N6300  · A01N6500  · A61K3170  · C12N500  · C12N502  ·
Kind CodeB2
This application is a national entry under 35 U.S.C. § 371 of PCT/NL01/00703, filed Sep. 25, 2001, published in English on Apr. 4, 2002, as WO 02/27006 A1, which claims the benefit of U.S. Provisional Application No. 60/235,665, filed Sep. 26, 2000.
PCT Application Number WO20PCTNL0100703 - 09/25/2001
PCT Publication Number WO200227006 - 04/04/2002
Foreign Priority EP00203336 - 09/26/2000 ·
3 Claims, 6 Drawings


The invention provides means and methods for transduction of a skeletal muscle cell and/or a muscle cell specific precursor thereof. Provided is the use of a gene delivery vehicle derived from an adenovirus, having a tropism for said cells, for the preparation of a medicament. In a preferred aspect of the invention, said gene delivery vehicle comprises at least a tropism determining part of an adenoviral fiber protein of subgroup B and/or F. More preferably, said gene delivery vehicle comprises at least part of a fiber protein of an adenovirus of stereotype (11, 16, 35, 40 and/or 51) or a functional part, derivative and/or analogue thereof.

Independent Claims | See all claims (3)

  1. 1. A method of delivering a nucleic acid of interest to a human skeletal muscle cell in vitro or a human myoblast cell in vitro, the method comprising: delivering the nucleic acid of interest to said human skeletal muscle cell or said human myoblast cell by infecting said human skeletal muscle cell in vitro or said human myoblast cell in vitro with a replication-deficient recombinant serotype 5 adenovirus, said recombinant serotype 5 adenovirus having a tropism for said human skeletal muscle cell or said human myoblast cell, said recombinant serotype 5 adenovirus comprising an adenoviral genomic nucleic acid comprising the nucleic acid of interest; wherein said recombinant serotype 5 adenovirus comprises a fiber protein comprising a knob and a shaft region from the fiber protein of an adenovirus serotype selected from the group consisting of serotypes 11, 13, 16, 17, 35, 38, 40-S, 40-L, 47 and 51.

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