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US7582733: Humanized antibodies that recognize beta amyloid peptide

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Filing Information

Inventor(s) Guriq Basi · Jose William Saldanha ·
Assignee(s) Elan Pharma International Limited · Wyeth ·
Attorney/Agent(s) Townsend and Townsend and Crew LLP ·
Primary Examiner Larry R. Helms ·
Assistant Examiner Meera Natarajan ·
Application Number US10232030
Filing date 08/30/2002
Issue date 09/01/2009
Prior Publication Data
Predicted expiration date 11/30/2018
U.S. Classifications 530/387.1  · 530/388.24  ·
International Classifications C07K1600  ·
Kind CodeB2
Related U.S. Application DataRELATED APPLICATIONS
The instant application is a continuation of U.S. patent application Ser. No. 10/010,942, filed Dec. 6, 2001 (granted Mar. 13, 2007 as U.S. Pat. No 7,189,819, which claims the benefit of U.S Provisional Patent Application Ser. No. 60/251,892, filed Dec. 6, 2000 (expired). The entire content of the above-referenced application are incorporated herein by reference.
13 Claims, 10 Drawings


Abstract

The invention provides improved agents and methods for treatment of diseases associated with amyloid deposits of Aβ in the brain of a patient. Preferred agents include humanized antibodies.

Independent Claims | See all claims (13)

  1. 1. A humanized antibody; which specifically binds to beta amyloid peptide (Aβ) with a binding affinity of at least 107 M−1, or antigen binding fragment thereof selected from the group consisting of a Fab, a Fab′, F(ab′)2, a FV, and a single-chain antibody, wherein the humanized antibody comprises: (i) a humanized light chain comprising three complementarity determining regions (CDR1, CDR2, and CDR3) from the 3D6 immunoglobulin light chain variable region sequence set forth as SEQ ID NO:2, and a light chain variable region framework sequence, wherein at least three framework positions selected from the group consisting of L1, L2, L36, and L46 (Kabat numbering convention) are occupied by Y, V, L and R, respectively, and (ii) a humanized light chain comprising three comnplementarity determining regions (CDR1, CDR2, and CDR3) from the 2D6 immunoglobulin heavy chain variable region sequence set forth as SEQ ID NO:4, and a heavy chain variable regions framework sequence, wherein framework positions H49, H93, and H94 (Kabat numbering convention) are occupied by A, V, and R respectively.

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