• Basket
  • Log in

Join
today

Boliven PRO is more than just patent search

  • Build and save lists using the powerful Lists feature
  • Analyze and download your search results
  • Share patent search results with your clients

New to Patents? Find out more from CambridgeIP ®

Patents »

US7605308: Regulation of quinolate phosphoribosyl transferase expression

Share

Share on Linked In Share on Facebook Share by Email

Filing Information

Inventor(s) Mark A. Conkling · Wen Song · Nandini Mendu ·
Assignee(s) North Carolina State University ·
Attorney/Agent(s) Myers Bigel Sibley & Sajovec, P.A. ·
Primary Examiner Russell Kallis ·
Application Number US9963340
Filing date 09/24/2001
Issue date 10/20/2009
Prior Publication Data
Predicted expiration date 08/10/2018
Patent term adjustment 181
U.S. Classifications 800/317.3  · 536/232  · 800/298  · 536/231  · 800/286  · 536/236  · 435/419  · 800/285  ·
International Classifications A01H500  · A01H510  · C12N1529  · C12N1552  · C12N1554  · C12N1582  ·
Kind CodeB2
Related U.S. Application DataCROSS REFERENCE TO RELATED APPLICATION
This application is a continuation of U.S. application Ser. No. 09/021,286, filed Feb. 10, 1998, now U.S. Pat. No. 6,586,661, which claims the benefit of U.S. Provisional Application No. 60/049,471 filed Jun. 12, 1997, the disclosures of which are hereby incorporated herein in their entirety by reference.
28 Claims, 7 Drawings


Abstract

DNA encoding a plant quinolate phosphoribosyl transferase (QPRTase) enzyme, and constructs comprising such DNA are provided. Methods of altering quinolate phosphoribosyl transferase expression are provided.

Independent Claims | See all claims (28)

  1. 1. An isolated nucleic acid comprising a nucleotide sequence selected from the group consisting of: a) a nucleotide sequence comprising at least 20 consecutive nucleotides of the complement of the nucleotide sequence of SEQ ID NO: 1; b) a nucleotide sequence comprising at least 30 consecutive nucleotides of the complement of the nucleotide sequence of SEQ ID NO: 1; c) a nucleotide sequence comprising at least 50 consecutive nucleotides of the complement of the nucleotide sequence of SEQ ID NO: 1; d) a nucleotide sequence comprising at least 75 consecutive nucleotides of the complement of the nucleotide sequence of SEQ ID NO: 1; e) a nucleotide sequence comprising at least 100 consecutive nucleotides of the complement of the nucleotide sequence of SEQ ID NO: 1; f) a nucleotide sequence comprising at least 125 consecutive nucleotides of the complement of the nucleotide sequence of SEQ ID NO: 1; g) a nucleotide sequence comprising at least 150 consecutive nucleotides of the complement of the nucleotide sequence of SEQ ID NO: 1; h) a nucleotide sequence comprising at least 200 consecutive nucleotides of the complement of the nucleotide sequence of SEQ ID NO: 1; and i) a nucleotide sequence having at least 95% identity with the nucleotide sequence of any of (a)-(h) above.
  2. 10. A seed of a tobacco plant according to claim or 4 or 8, or a progeny thereof, wherein said seed is a transgenic seed.
  3. 13. An isolated nucleic acid comprising a nucleotide sequence selected from the group consisting of: a) a nucleotide sequence comprising at least 20 consecutive nucleotides of the nucleotide sequence of SEQ ID NO: 1; b) a nucleotide sequence comprising at least 30 consecutive nucleotides of the nucleotide sequence of SEQ ID NO: 1; c) a nucleotide sequence comprising at least 50 consecutive nucleotides of the nucleotide sequence of SEQ ID NO: 1; d) a nucleotide sequence comprising at least 75 consecutive nucleotides of the nucleotide sequence of SEQ ID NO: 1; e)a nucleotide sequence comprising at least 100 consecutive nucleotides of the nucleotide sequence of SEQ ID NO: 1; f) a nucleotide sequence comprising at least 125 consecutive nucleotides of the nucleotide sequence of SEQ ID NO: 1; g) a nucleotide sequence comprising at least 150 consecutive nucleotides of the nucleotide sequence of SEQ ID NO: 1; h) a nucleotide sequence comprising at least 200 consecutive nucleotides of the nucleotide sequence of SEQ ID NO: 1; i) a nucleotide sequence having at least 95% identity with the nucleotide sequence of any of (a)-(h) above.

References Cited

U.S. Patent Documents

Document NumberAssigneesInventorsIssue/Pub Date
US254285 Forest Feb 1882
US299541 Hearn Jun 1884
US2479526 WURTON MACHINE COMPANY Touton Aug 1949
US2728603 STAGG JAMES H Helijo Aug 1955
US3840025 INDUSTRIAL NUCLEONICS CORP Fowler et al. Oct 1974
US3905123 INDUSTRIAL NUCLEONICS CORP Fowler et al. Sep 1975
US4094324 Deutsche Benkert GmbH & Co., K.G. Bolsinger et al. Jun 1978
US4192323 Gas-Fired Products, Inc. Horne Mar 1980
US4243056 Philip Morris Incorporated de la Burde et al. Jan 1981
US4319587 Irving S. Moser Moser Mar 1982
US4372208 Decoufle S.A.R.L. Legardinier Feb 1983
US4459355 International Paper Company Cello et al. Jul 1984
US4499911 JOHNSON WILLIAM H Johnson Feb 1985
US4557280 Brown & Williamson Tobacco Corporation Gravely et al. Dec 1985
US4617945 Naarden International N.V. Vos et al. Oct 1986
US4693976 SCHILPEROORT ROBBERT A Schilperoort Sep 1987
US4699158 Philip Morris Incorporated Sprinkel Oct 1987
US4700725 Philip Morris Incorporated Geiszler Oct 1987
US4751348 Cold Spring Harbor Laboratory Malmberg et al. Jun 1988
US4762785 Calgene, Inc. Comai Aug 1988
US4766911 R. J. Reynolds Tobacco Company Oglesby Aug 1988
US4793367 Rothmans of Pall Mall Canada Limited Brackmann Dec 1988
US4795855 FILLATTI JOANNE Fillatti et al. Jan 1989
US4821747 R. J. Reynolds Tobacco Company Stuhl et al. Apr 1989
US4835162 ABOOD LEO G Abood May 1989
US4885248 Lubrizol Genetics, Inc. Ahlquist Dec 1989
US4940838 SCHILPEROORT ROBBERT A Schilperoort et al. Jul 1990
US4943674 Calgene, Inc. Houck et al. Jul 1990
US4945050 Cornell Research Foundation, Inc. Sanford et al. Jul 1990
US4954442 Purdue Research Foundation Gelvin et al. Sep 1990
US4962028 DNA Plant Technology Corporation Bedbrook et al. Oct 1990
US4966916 ABOOD LEO G Abood Oct 1990
US4990607 The Rockefeller University Katagiri et al. Feb 1991
US5015580 Agracetus Christou et al. May 1991
US5023179 LAM ERIC Lam et al. Jun 1991
US5034322 Monsanto Company Rogers et al. Jul 1991
US5036006 Cornell Research Foundation, Inc. Sanford et al. Jul 1991
US5062434 Brown & Williamson Tobacco Corporation Aulbach et al. Nov 1991
US5097025 The Rockefeller University Benfey et al. Mar 1992
US5100792 Cornell Research Foundation, Inc. Sanford et al. Mar 1992
US5107065 Calgene, Inc. Shewmaker et al. Apr 1992
US5109876 R. J. Reynolds Tobacco Company Hayden et al. May 1992
US5149645 Rijksuniversiteit Leiden Hoekema et al. Sep 1992
US5157115 Taniguchi Oct 1992
US5177308 Agracetus Barton et al. Jan 1993
US5179022 E. I. Du Pont de Nemours & Co. Sanford et al. Jan 1993
US5190931 The Research Foundation of State University of New York Inouye et al. Mar 1993
US5204253 E. I. Du Pont de Nemours and Company Sanford et al. Apr 1993
US5208149 The Research Foundation of State University of New York Inouye et al. May 1993
US5223419 The Rockefeller University Katagiri et al. Jun 1993
US5229292 Stine Seed Farm, Inc. Stock et al. Jul 1993
US5231020 DNA Plant Technology Corporation Jorgensen et al. Jul 1993
US5254800 Imperial Chemical Industries PLC Bird et al. Oct 1993
US5260205 Philip Morris Incorporated Nakatani et al. Nov 1993
US5268463 JEFFERSON RICHARD A Jefferson Dec 1993
US5272065 Research Foundation of State University of New York Inouye et al. Dec 1993
US5283184 DNA Plant Technology Corporation Jorgensen et al. Feb 1994
US5352605 Monsanto Company Fraley et al. Oct 1994
US5356799 Pioneer Hi-Bred International, Inc. Fabijanski et al. Oct 1994
US5365015 Imperial Chemical Industries PLC Grierson et al. Nov 1994
US5369023 Philip Morris Incorporated Nakatani et al. Nov 1994
US5371015 Cornell Research Foundation, Inc. Sanford et al. Dec 1994
US5377697 Hoechst Celanese Corporation Deutsch et al. Jan 1995
US5394894 Zade Mar 1995
US5432081 Cambia Biosystems, L.L.C. Jefferson Jul 1995
US5451514 Zeneca Limited Boudet et al. Sep 1995
US5453566 Calgene, Inc. Shewmaker et al. Sep 1995
US5459252 North Carolina State University Conkling et al. Oct 1995
US5464763 Rijksuniversiteit Leiden Schilperoort et al. Nov 1995
US5478744 Cornell Research Foundation, Inc. Sanford et al. Dec 1995
US5501967 Mogen International, n.v./Rijksuniversiteit te Leiden Offringa et al. Mar 1996
US5530196 Monsanto Company Fraley et al. Jun 1996
US5540242 Brown & Williamson Tobacco Corporation Chao et al. Jul 1996
US5580722 Oncogene Science, Inc. Foulkes et al. Dec 1996
US5599670 Cambia Biosystems. L.L.C. Jefferson Feb 1997
US5610288 Hekton Institute for Medical Research Rubenstein Mar 1997
US5626152 Molins PLC Davis et al. May 1997
US5635381 Mogen International NV Hooykaas et al. Jun 1997
US5665543 Oncogene Science, Inc. Foulkes et al. Sep 1997
US5668295 Philip Morris Incorporated Wahab et al. Sep 1997
US5683985 The Salk Institute for Biological Studies Chu et al. Nov 1997
US5684241 Philip Morris Incorporated Nakatani et al. Nov 1997
US5685710 Martinez Sagrera et al. Nov 1997
US5693512 The Ohio State Research Foundation Finer et al. Dec 1997
US5713376 Berger Feb 1998
US5716780 Genelabs Technologies, Inc. Edwards et al. Feb 1998
US5723751 The Trustees of Rockefeller University Chua Mar 1998
US5731179 Japan Tobacco Inc. Komari et al. Mar 1998
US5759829 Calgene, Inc. Shewmaker et al. Jun 1998
US5767378 Novartis AG Bojsen et al. Jun 1998
US5776502 Oncogene Science, Inc. Foulkes et al. Jul 1998
US5776771 Nitto Chemical Industry Co., Ltd. Yu et al. Jul 1998
US5780051 DynaGen, Inc. Eswara et al. Jul 1998
US5792922 Sembiosys Genetics Inc. Moloney Aug 1998
US5796500 Voxel Hart Aug 1998
US5803081 Regent Court Technologies O'Donnell et al. Sep 1998
US5810020 Osmotek, Inc. Northway et al. Sep 1998
US5819751 R. J. Reynolds Tobacco Company Barnes et al. Oct 1998
US5830318 Schweitzer-Mauduit International, Inc. Snow et al. Nov 1998
US5830728 Agracetus, Inc. Christou et al. Nov 1998
US5834236 The Salk Institute for Biological Studies Lamb et al. Nov 1998
US5837876 North Carolina State University Conkling et al. Nov 1998
US5843720 Novo Nordisk A/S Tangney et al. Dec 1998
US5845647 Regent Court Technologies O'Donnell et al. Dec 1998
US5846720 Oncogene Science, Inc. Foulkes et al. Dec 1998
US5851804 Apollon, Inc. Snyder et al. Dec 1998
US5858742 Monsanto Company Fraley et al. Jan 1999
US5858774 The Research Foundation of State University of New York Malbon et al. Jan 1999
US5862750 Oranmay Investments B.V. Dell'Olmo Jan 1999
US5863733 Oncogene Science, Inc. Foulkes et al. Jan 1999
US5877023 Novartis Finance Corp. Sautter et al. Mar 1999
US5929306 University of Kentucky Research Foundation Torisky et al. Jul 1999
US5932782 Pioneer Hi-Bred International, Inc. Bidney Aug 1999
US5962768 PLANT GENETIC SYSTEMS NV Cornelissen et al. Oct 1999
US5976793 Oncogene Science, Inc. Foulkes et al. Nov 1999
US5976880 Novartis Finance Corporation Sautter et al. Nov 1999
US5981839 Calgene, LLC Knauf et al. Nov 1999
US5989915 Monsanto Company Christou et al. Nov 1999
US5994629 Novartis AG Bojsen et al. Nov 1999
US6020969 Philip Morris Incorporated Struckhoff et al. Feb 2000
US6022863 Yale University Peyman Feb 2000
US6051409 Novartis Finance Corporation Hansen et al. Apr 2000
US6051757 Washington University Barton et al. Apr 2000
US6060310 The United States of America as represented by the Department of Health and Human Services Cho-Chung May 2000
US6065592 Wik May 2000
US6077992 E. I. du Pont de Nemours and Company Yadav Jun 2000
US6135121 Regent Court Technologies Williams Oct 2000
US6136779 OSI Pharmaceuticals, Inc. Foulkes et al. Oct 2000
US6153811 Dekalb Genetics Corporation Lowe et al. Nov 2000
US6165712 OSI Pharmaceuticals, Inc. Foulkes et al. Dec 2000
US6165715 Cancer Research Campaign Technology Limited Collins et al. Dec 2000
US6166032 Synapse Pharmaceuticals International, Inc. Viner Dec 2000
US6174724 Monsanto Company Rogers et al. Jan 2001
US6191258 The Salk Institute for Biological Studies Lamb et al. Feb 2001
US6197827 Cary Medical Corporation Cary Mar 2001
US6202649 Regent Court Technologies Williams Mar 2001
US6203976 OSI Pharmaceuticals, Inc. Foulkes et al. Mar 2001
US6255560 Monsanto Company Fraley et al. Jul 2001
US6262033 Fujisawa Pharmaceutical Co., Ltd. Morishita et al. Jul 2001
US6265638 Pioneer Hi-Bred International, Inc. Bidney et al. Jul 2001
US6271031 E.I. du Pont de Nemours and Company Falco et al. Aug 2001
US6279475 Decoufl s.a.r.l. Cardoso Aug 2001
US6281410 Calgene LLC Knauf et al. Aug 2001
US6303847 Nippon Paper Industries Co., Ltd. Kawaoka et al. Oct 2001
US6350479 Regent Court Technologies Williams et al. Feb 2002
US6423520 North Carolina State University Conkling et al. Jul 2002
US6425401 Regent Court Technologies LLC Williams Jul 2002
USRE38123 Regent Court Technologies, LLC. Williams May 2003
US6557560 CTC Canada Inc. Kastner May 2003
US6584981 Schweitzer-Mauduit International, Inc. Hampl, Jr. Jul 2003
US6586661* North Carolina State University Conkling et al. Jul 2003
US6907887 Vector Tobacco Ltd. Conkling Jun 2005
US6911541 North Carolina State University Conkling Jun 2005
US7304220 North Carolina State University Conkling et al. Dec 2007
US20010006797 Kumagai et al. Jul 2001
US20010026941 Held et al. Oct 2001
US20020174874 Regent Court Technologies LLC Williams Nov 2002
US20030018997 Conkling et al. Jan 2003
US20030140366 Conkling et al. Jul 2003
US20040031074 Conkling et al. Feb 2004
US20040103454 Conkling et al. May 2004
US20040168211 Conkling et al. Aug 2004
US20060057723 CONKLING MARK A Conkling et al. Mar 2006
US20060157072 ALBINO ANTHONY Albino et al. Jul 2006
US20070240728 Nara Institute of Science and Technology Hashimoto et al. Oct 2007

Foreign Patent Documents

Document NumberAssigneesInventorsIssue/Pub Date
CA2032443EIDGENOESS TECH HOCHSCHULEJun 1991
CA2248622CELESTE JOEMar 1999
CA2325344COMMW SCIENT IND RES ORGOct 1999
CA1341091UNIV NEW YORKSep 2000
DE11917552Apr 1969
DE2203105REYNOLDS LEASING CORPJan 1972
EP0116718Max-Planck-Gesellschaft zur FrderungAug 1984
EP0120515RIJKSUNIVERSITEIT LEIDENOct 1984
EP0120515BOct 1984
EP0120516RIJKSUNIVERSITEIT LEIDENOct 1984
EP0120516RIJKSUNIVERSITEIT LEIDENOct 1984
EP0131620Monsanto CompanyJan 1985
EP0131623Monsanto CompanyJan 1985
EP0131624Monsanto CompanyJan 1985
EP0140308THE RESEARCH FOUNDATION OFMay 1985
EP0140308THE RESEARCH FOUNDATION OFMay 1985
EP0140308THE RESEARCH FOUNDATION OFMay 1985
EP0140308THE RESEARCH FOUNDATION OFMay 1985
EP0159779LUBRIZOL GENETICS INC.Oct 1985
EP0176112Rijksuniversiteit LeidenApr 1986
EP176112Apr 1986
EP0189707PLANT GENETIC SYSTEMS N.V.Aug 1986
EP0223399AGRACETUS, INC.May 1987
EP0223399AGRACETUS, INC.May 1987
EP0224287Rijksuniversiteit LeidenJun 1987
EP0240208CALGENE, INC.Oct 1987
EP0240208CALGENE, INC.Oct 1987
EP0240208CALGENE, INC.Oct 1987
EP0265556Max-Planck-Gesellschaft zur FrderungMay 1988
EP0270822Max-Planck-Gesellschaft zur FrderungJun 1988
EP0290799Max-Planck-Gesellschaft zur FrderungNov 1988
EP0290799Max-Planck-Gesellschaft zur FrderungNov 1988
EP0290799Max-Planck-Gesellschaft zur FrderungNov 1988
EP0320500Max-Planck-Gesellschaft zur FrderungJun 1989
EP0320500Max-Planck-Gesellschaft zur FrderungJun 1989
EP0131623Monsanto CompanyMar 1991
EP0458367Calgene LLCNov 1991
EP0458367Calgene LLCNov 1991
EP0467349THE RESEARCH FOUNDATION OFJan 1992
EP0486214Philip Morris Products Inc.May 1992
EP0486214Philip Morris Products Inc.May 1992
EP0486234PIONEER HI-BRED INTERNATIONAL, INC.May 1992
EP0647715DNA Plant Technology CorporationApr 1995
EP0818532TAKARA BIO INC.Jan 1998
EP1457562UNIV NORTH CAROLINASep 2004
EP1457563UNIV NORTH CAROLINASep 2004
WO198402913Aug 1984
WO198402919Aug 1984
WO198402920Aug 1984
WO199012084Oct 1990
WO199101379Feb 1991
WO199102070Feb 1991
WO199111535Aug 1991
WO199113992Sep 1991
WO199114790Oct 1991
WO199215680Sep 1992
WO199218522Oct 1992
WO199219732Nov 1992
WO199305163Mar 1993
WO199305646Apr 1993
WO199314768Aug 1993
WO199317116Sep 1993
WO199420627Sep 1994
WO199426913Nov 1994
WO199428142Dec 1994
WO199428142Dec 1994
WO199511687May 1995
WO199512415May 1995
WO199516031Jun 1995
WO199534668Dec 1995
WO199535388Dec 1995
WO199621725Jul 1996
WO199705261Feb 1997
WO199708330Mar 1997
WO199712046Apr 1997
WO199732016Sep 1997
WO199738723Oct 1997
WO199741892Nov 1997
WO199744064Nov 1997
WO199744450Nov 1997
WO199749727Dec 1997
WO199805226Feb 1998
WO199805757Feb 1998
WO199830701Jul 1998
WO199832843Jul 1998
WO199856923Dec 1998
WO199856932Dec 1998
WO199910512Mar 1999
WO199913085Mar 1999
WO199914348Mar 1999
WO199925854May 1999
WO199926634Jun 1999
WO199932619Jul 1999
WO199932642Jul 1999
WO199949029Sep 1999
WO199953050Oct 1999
WO199961631Dec 1999
WO200012735MONSANTO CO.Mar 2000
WO200018939PIONEER HI-BRED INTERNATIONAL, INC.Apr 2000
WO200029566ETH ZRICHMay 2000
WO200037060NATIONAL RESEARCH COUNCIL OF CANADAJun 2000
WO200037663THE SAMUEL ROBERTS NOBLE FOUNDATION, INC.Jun 2000
WO2000055333CAMBIA BIOSYSTEMS LLCSep 2000
WO200063398RHOBIOOct 2000
WO200067558Michael TIMKONov 2000
WO200109302MONSANTO COMPANYFeb 2001
WO200138514MIDWEST OILSEEDS, INC.May 2001
WO200144482CROPDESIGN N.V.Jun 2001
WO200149844RUTGERS, THE STATE UNIVERSITY OF NEW JERSEYJul 2001
WO200151630BAYLOR UNIVERSITYJul 2001
WO200168836GENETICA, INC.Sep 2001
WO200177350Oct 2001
WO200200927EPIGENOMICS AGJan 2002
WO200218607NORTH CAROLINA STATE UNIVERSITYMar 2002
WO200238588NORTH CAROLINA STATE UNIVERSITYMay 2002
WO2002100199VECTOR TOBACCO LTD.Dec 2002
WO200501830722ND CENTURY LIMITED, LLCMar 2005
WO2008020333NATIONAL RESEARCH COUNCIL OF CANADAFeb 2008
WO2008070274NORTH CAROLINA STATE UNIVERSITYJun 2008
* cited by examiner

Other Publications

Hughes K. et al., Journal of Bacteriology; Jan. 1993, vol. 175, No. 2; pp. 479-486.*
Elomaa P. et al., Molecular Breeding 1996, vol. 2, pp. 41-50.*
Waterhouse P. et al., Trends in Plant Sciences, Nov. 1999, vol. 4, No. 11 pp. 452-457.*
Levin J. et al. Plant Molecular Biology; 2000, vol. 44, pp. 759-775.*
European Search Report Application No. 04004191.5, Jul. 12, 2004.
European Search Report Application No. 04004192.3, Jul. 12, 2004.
Hamill et al., “Over-expressing a yeast ornithine decarboxylase gene in transgenic roots of Nicotiana rustica can lead to enhanced nicotine accumulation,” Plant Molecular Biology, vol. 15, 1990, pp. 27-38.
Database EMBL Online! EBI; clone TAP0198, Mar. 5, 1996, XP002285509, 2 pages.
Holmberg et al., “Transgenic tobacco expressing Vitreoscilla hemoglobin exhibits enhanced growth and altered metabolite production”, Nature Biotechnology, vol. 15, 1997, pp. 244-247.
Abeyama et al. “A role for NF-κB-Dependent Gene Transactivation in Sunburn” The Journal of Clinical Investigation 105(12):1751-1759 (Jun. 2000).
Adam et al. (1995) “Transcription of tobacco phytochrome-A genes initiates at multiple start sites and requires multiple cis-acting regulatory elements.” Plant Mol. Biol. 29(5):983-993.
Akimoto et al. “Growth Inhibition of Cultured Human Tenon's Fibroblastic Cells by Targeting the E2F Transcription Factor” Exp. Eye Res. 67:395-401 (1998).
Aparicio et al. (2001) “Recognition of cis-acting sequences in RNA 3 of Prunus necrotic ringspot virus by the replicase of Alfalfa mosaic virus”. J. Gen. Virol. 82(Pt 4):947-951.
Blastn 2.2.3 RID: 1028939485-09139-26659 http://www.ncbi.nlm.nih.gov/blast/Blast.cgi, Apr. 24, 2002.
Blastn 2.2.3 RID: 1029876573-03236-18654 http://www.ncbi.nlm.nih.gov/blast/Blast.cgi, Apr. 24, 2002.
Bogusz et al. “Functioning Haemoglobin Genes in Non-Nodulating Plants” Nature 331:178-180 (1988).
Borisjuk et al. (2000) “Tobacco ribosomal DNA spacer element stimulates amplification and expression of heterologous genes” Nat. Biotechnol. 18(12):1303-1306.
Bustos et al. (1989) “Regulation of β-glucuronidase expression in transgenic tobacco plants by an A/T-rich, cis-acting sequence found upstream of a French bean β-phaseolin gene” Plant Cell 1(9):839-853.
Clusel et al. (1995) “Inhibition of HSV-1 proliferation by decoy phosphodiester oligonucleotides containing ICP4 recognition sequences” Gene Expr. 4(6):301-309.
D'Acquisto et al. “Local Administration of Transcription Factor Decoy Oligonucleotides to Nuclear Factor-κB Prevents Carrageenin-Induced Inflammation in Rat Hind Paw” Gene Therapy 7:1731-1737 (2000) (abstract only).
GenBank accession No. U08931, Nicotiana tabacum cryptic seed coat-specific promoter (1994).
Ehsan et al. (2001) “Long-term stabilization of vein graft wall architecture and prolonged resistance to experimental atherosclerosis after E2F decoy oligonucleotide gene therapy” J. Thorac. Cardiovasc. Surg. 121(4):714-722.
Evans et al. Distribution of Root RNA Species in Other Vegetative Organs of Pea (Pisum sativum L. ) Mol. Gen. Genet. 214:153-157 (1988).
Fobert et al. “T-DNA Tagging of a Seed Coat-Specific Cryptic Promoter in Tobacco” Plant Journal 6(4):567-577 (1994).
Fuller et al. “Soybean Nodulin Genes: Analysis of cDNA Clones Reveals Several Major Tissue-Specific Sequences in Nitrogen-Fixing Root Nodules” Proc. Natl. Acad. Sci. USA 80:2594-2598 (1983).
Geffers et al. (2000) “Anaerobiosis-specific interaction of tobacco nuclear factors with cis-regulatory sequences in the maize GapC4 promoter” Plant Mol. Biol. 43(1):11-21.
Genbank Accession No. AC021028. Homo sapiens chromosome 10 clone RP11-137H2, 44 pp. (2002).
Hashimoto et al. “Intraspecific Variability of the Tandem Repeats in Nicotiana Putrescine N-Methyltransferases” Plant Molecular Biology 37:25-37 (1998).
Hsu et al. “Phloem Mobility of Xenobiotics VI.A Phloem-Mobile Pro-Nematocide based on Oxamyl Exhibiting Root-Specific Activation in Transgenic Tobacco” Pestic. Sci. 44:9-19 (1995).
International Search Report for International Application Serial No. PCT/US01/47371, mailed Aug. 18, 2003.
International Search Report for International Application Serial No. PCT/US01/26788, mailed Jul. 17, 2002.
Johnson et al. (2001) “Regulation of DNA binding and trans-activation by a xenobiotic stress-activated plant transcription factor” J. Biol. Chem. 276(1):172-178.
Keller et al. “Specific Expression of a Novel Cell Wall Hydroxyproline-Rich Glycoprotein Gene in Lateral Root Initiation” Genes & Dev. 3:1639-1646 (1989) (Abstract only).
Kitamoto et al. “Increased Activity of Nuclear Factor-κB Participates in Cardiovascular Remodeling Induced by Chronic Inhibition of Nitric Oxide Synthesis in Rats” Circulation 102:806-812 (2000).
Konopka (2000) “Rev-binding aptamer and CMV promoter act as decoys to inhibit HIV replication” Gene 255(2):235-244.
Kubota et al. “Cloning of a Nuclear-Encoded Photosystem 1 Gene, psaEb, in Nicotiana sylvestris” Plant Physiol 108:1297-1298 (1995).
Lee et al. “CRE-Transcription Factor Decoy Oligonucleotide Inhibition of MCF-7 Breast Cancer Cells: Cross-Talk with p53 Signaling Pathway” Biochemistry 39:4863-4868 (2000).
Lerner et al. “Cloning and Characterization of Root-Specific Barley Lectin” Plant Physiology 91:124-129 (1989).
Maniatis et al. “Regulation of Inducible and Tissue Specific Gene Expression” Science 237:1237-1244 (1987).
Mann et al. “Ex-vivo Gene Therapy of Human Vascular Bypass Grafts with E2F Decoy: The PREVENT Single-Centre, Randomised, Controlled Trial” The Lancet 354:1493-1498 (Oct. 30, 1999).
Mann et al. “Pressure-Mediated Oligonucleotide Transfection of Rat and Human Cardiovascular Tissues” Proc. Natl. Acad. Sci. USA 96:6411-6416 (May 1999).
Mischiati et al. “Interaction of the Human NF-κB p. 52 Transcription Factor with DNA-PNA Hybrids Mimicking the NF-κB Binding Sites of the Human Immunodeficiency Virus Type 1 Promoter” The Journal of Biological Chemistry 274(46):33114-33122 (1999).
Morishita et al. (1995) “A gene therapy strategy using a transcription factor decoy of the E2F binding site inhibits smooth muscle proliferation in vivo” Proc. Natl. Acad. Sci. USA 92(13):5855-5859.
Morishita et al. “Application of Transcription Factor “Decoy” Strategy as Means of Gene Therapy and Study of Gene Expression in Cardiovascular Disease” Circ. Res. 82:1023-1028 (1998).
Morishita et al. “Role of AP-1 Complex in Angiotensin II-Mediated Transforming Growth Factor-β Expression and Growth of Smooth Muscle Cells: Using Decoy Approach Against AP-1 Binding Site” Biochemical and Biophysical Research Communications 243:361-367 (1998).
Nastruzzi et al. “Liposomes as Carriers for DNA-PNA Hybrids” Journal of Controlled Release 68:237-249 (2000).
GenBank Accession No. D42070 Tobacco psaEb gene for PSI-E subunit of photosystem I (1995).
GenBank Accession No. X70902 N.tobacum T85 gene for auxin-binding protein (1998).
Park et al. “Dual Blockade of Cyclic AMP Response Element-(CRE) and AP-1-Directed Transcription by CRE-Transcription Factor Decoy Oligonucleotide” The Journal of Biological Chemistry 274(3):1573-1580 (Jan. 15, 1999).
Piva et al. “Modulation of Estrogen Receptor Gene Transcription in Breast Cancer Cells by Lipsome Delivered Decoy Molecules” Journal of Steroid Biochemistry and Molecular Biology 75:121-128 (2000).
Rafty et al. “Novel Negative Regulator Element in the Platelet-Derived Growth Factor B Chain Promoter That.Mediates ERK-Dependent Transcriptional Repression” The Journal of Biological Chemistry 275(15):11478-11483 (2000).
Reichers et al., “Structure and Expression of the Gene Family Encoding Putrescine N-methyltransferase in Nicotiana tabacum: New Clues to the Evolutionary Origin of Cultivated Tobacco” Plant Molecular Biology 41:387-401 (1999).
Sanford et al. “The Biolistic Process” Trends in Biotechnology 6:299-302 (1988).
Sharma et al. (1996) “Transcription factor decoy approach to decipher the role of NF-kB in oncogenesis” Anticancer Res. 16(1):61-70.
Siebertz et al. (1989) “cis-Analysis of the wound-inducible promoter wun1 in transgenic tobacco plants and histochemical localization of its expression” Plant Cell 1(10):961-968.
Singer et al. “Transcription: The Transfer of DNA Sequence Information to RNA” Genes and Genomes section 3.2: 134-145, University Science Books, Mill Valley, CA (1991).
Takata et al. “Novel Cis Element for Tissue-Specific Transcription of Rat Platelet-Derived Growth Factor β-Receptor Gene” Hypertension 33(II):298-302 (1999).
Tomita et al. “Transcription Factor Decoy for NF B Inhibits Cytokine and Adhesion Molecule Expressions in Synovial Cells Derived from Rheumatoid Arthritis” Rheumatology 39:749-757 (2000).
Wadgaonkar et al. (1999) “CREB-binding protein is a nuclear integrator of nuclear factor-kB and p53 signaling” J. Biol. Chem. 274(4):1879-1882.
Wang et al. (1992) “Characterization of cis-acting elements regulating transcription from the promoter of a constitutively active rice actin gene” Mol. Cell Biol. 12(8):3399-3406.
Wang et al. “Targeted Disruption of Stat6 DNA Binding Activity by an Oligonucleotide Decoy Blocks IL-4-Driven TH2 Cell Response” Blood 95(4):1249-1257 (Feb. 15, 2000).
Watanabe et al. “Cloning and Expression of Two Genes Encoding Auxin-Binding Proteins From Tobacco” Plant Molecular Biology 36:63-74 (1998).
Wu et al. “Inhibition of In Vitro Transcription by Specific Double-Stranded Oligodeoxyribonucleotides” Gene 89:203-209 (1990).
Yamamoto “A Tobacco Root-Specific Gene; Characterization and Regulation of its Expression” J. Cell Biochem. 13(D) (Suppl.) (1989) (Abstract).
Yamamoto “A Tobacco Root-Specific Gene; Characterization and Regulation of its Transcription” Ph.D. Thesis submitted to the Graduate Faculty of North Carolina State University. Genetics Department (1989).
Yamamoto et al. “Root-Specific Genes from Tobacco and Arabidopsis homologous to an Evolutionary Conserved Gene Family of Membrane Channel Proteins” Nucleic Acids Research 18:7449 (1990).
Yamamoto et al. (1991) Characterization of cis-acting sequences regulating root-specific gene expression in tobacco. Plant Cell 3(4):371-382.
Yia-Herttuala et al. “Cardiovascular Gene Therapy” The Lancet 355:213-222 (Jan. 15, 2000).
Brunnemann et al. “Assessment of Carcinogenic Volatile N-Nitrosamines in Tobacco and in Mainstream and Sidestream Smoke from Cigarettes” Cancer Research 37:3218-3222 (1977).
Brunnemann et al. “Recent Advances in Tobacco Science: Analytical Studies on N-Nitrosamines in Tobacco and Tobacco Smoke” Proceedings of a Symposium Presented at the 45th Meeting of the Tobacco Chemists' Research Conference, vol. 17, Oct. 20, 1991, Oct. 23, 1991, The Grove Park Inn, Asheville, North Carolina.
Burton et al. “Burley Tobacco—The Effects of Harvesting and Curing Procedures on the Composition of the Cured Leaf” Tobacco Science 5:49-53 (1988).
Chamberlain et al. “Curing Effects on Contents of Tobacco Specific Nitrosamines in Bright and Burley Tobaccos” USDA, ARS, pp. 1-41 (1986).
Chang et al. “Gene Expression from Both Intronless and Intron-Containing Rous Sarcoma Virus Clones is Specifically Inhibited by Anti-Sense RNA” Molecular and Cellular Biology 5(9):2341-2348 (1985).
Collins et al. “Use of Anther-Derived Haploids in Nicotiana. I. Isolation of Breeding Lines Differing in Total Alkaloid Content” Crop Sci. 14:77-80 (1974).
De Block et al. “Expression of Foreign Genes in Regenerated Plants and in Their Progeny” EMBO Journal 3(8):1681-1689 (1984).
Feth et al. “Determination of Putrescine N-methyltransferase By High Performance Liquid Chromatography” Phytochemistry 24(5): 921-923 (1985).
Higo et al. “Plant cis-acting regulatory DNA elements (PLACE) database: 1999” Nucleic Acids Research 27:297-300 (1999).
Lagrimini et al. “Peroxidase-Induced Wilting in Transgenic Tobacco Plants” The Plant Cell 2:7-18 (1990).
Leete et al. “Biosynthesis and Metabolism of the Tobacco Alkaloids” in Alkaloids: Chemical and Biological Perspectives, S.W. Pelletier, ed. John Wiley & Sons, pp. 85-152 (1983).
Legg et al. “Inheritance of Per Cent Total Alkaloids in Nicotiana Tabacum L. II Genetic Effects of Two Loci in Burley 21 X LA Burley 21 Populations” Can J Genet Cytol.13:287-91 (1971).
Mizusaki et al. “Phytochemical Studies on Tobacco Alkaloids XIV. The Occurrence and Properties of Putrescine N-methyltransferase in Tobacco Roots” Plant & Cell Physiology 12:633-640 (1971).
Napoli et al. “Introduction of a Chimeric Chalcone Synthase Gene into Petunia Results in Reversible Co-Suppression of Homologous Genes in trans” The Plant Cell 2:279-289 (1990).
Preiss et al. “Molecular genetics of Kruppel, a gene required for segmentation of the Drosophila embryo” Nature 313:27-32 (1985).
Rombauts et al. “PlantCARE, a plant cis-acting regulatory element database” Nucleic Acids Research 27:295-296 (1999).
Schroth et al. “Tobacco-Specific Nitrosamines,” Research and Development, Neuchatel-Quarterly Report, pp. 1-8, Apr.-Jun. 1994.
Shilito et al. “Direct Gene Transfer to Protoplasts of Dicotyledonous and Monocotyledonous Plants by a Number of Methods, Including Electroporation” Methods Enzymol. 153:313-36 (1987).
Watson “Nicotine free flavorful too” in The Buffalo News, A9and A15. Sep. 7, 1997 (newspaper article).
Wu et al. “The Arabidopsis 14-3-3 Multigene Family” Plant Physiol. 114:1421-1431 (1997).
Beck et al, “Nucleotide Sequence and Exact Localization of the Neomycin Phosphotransferase Gene from Transposon Tn 5”, Gene, 19: 327-336 (1982).
Bevan & Flavell, “A Chimaeric Antibiotic Resistance Gene as a Selectable Marker for Plant Cell Transformation”, Nature, 304: 184-187 (1983).
Chilton et al., “Tailoring the Agrobacterium Ti Plasmid as a Vector for Plant Genetic Engineering”, Stadler Symp., 13: 39-53 (1981).
Colbere-Garapin et al., “A New Dominant Hybrid Selective Marker for Higher Eukaryotic Cells”, J. Mol. Biol., 150: 1-14 (1981).
Davies and Jimenez, “A New Selective Agent for Eukaryotic Cloning Vectors”, Am. J. Trop. Med. Hyg., 29(5): 1089-1092 (1980).
Depicker et al., “Nopaline Synthase: Transcript Mapping and DNA Sequence”, Journal of Molecular and Applied Genetics, 1(6): 561-573 (1982).
Fraley et al., “Expression of Bacterial Genes in Plant Cells”, Proc. Natl. Acad. Sci. USA, 80: 4803-4807 (1983).
Fraley et al., “Use of a Chimeric Gene to Confer Antibiotic Resistance to Plant Cells”, Advances in Gene Technology: Molecular Genetics of Plants and Animals, 20: 211-221 (1983).
Framond et al., “Mini-Ti: A New Vector Strategy for Plant Genetic Engineering”, Bio/Technology, 5: 262-269 (1983).
Halk et al., “Cloning of Alfalfa Mosaic Virus Coat Protein Gene and Anti-Sense RNA into Binary Vector and Their Expression in Transformed Tobacco Tissue”, Molecular Strategies for Crop Protection, p. 41, 1986.
Hermaisteens et al., “The Agrobacterium Tumefaciens Ti Plasmid as a Host Vector System for Introducing Foreign DNA in Plant Cells”, Nature, 287: 654-656 (1980).
Herrera-Estrella et al., “Chimeric Genes as Dominant Selectable Markers in Plant Cells”, The Embo Journal, 2(6): 987-995 (1993).
Herrera-Estrella et al., “Expression of Chimaeric Genes Transferred into Plant Cells Using a Ti-Plasmid-Derived Vector”, Nature, 303: 209-213 (1983).
Hooykaas et al., “The Ti-Plasmid of Agrobacterium Tumefacines: A Natural Genetic Engineer”, TIBS,307-309 (1985).
Horsch et al., “A Simple and General Method for Transferring Genes into Plants”, Biological Sciences, 227: 1229-1231 (1985).
Lorz et al., “Transformation Studies Using Synthetic DNA Vectors Coding For Antibiotic Resistance”, Plant Tissue Culture, 511-512 (1982).
Smith et al., “Antisense RNA Inhibition of Polygalacturonase Gene Expression in Transgenic Tomatoes”, Nature, 334: 724-726 (1988).
Wang et al., “Right 25 bp Terminus Sequence of the Nopaline T- DNA is Essential for and Determines Direction of DNA Transfer from Agrobacterium to the Plant Genome”, Cell, 38: 455-462 (1984).
Database entry of Ensembl Human Genome Server, AC006461.2.1.181215, BLASTN 2.0a13MP-WashU [Jun. 10, 1997], 2 pp.
Database entry of Ensembl Human Genome Server, AC024028.10.1.176278, BLASTN 2.0a13MP-WashU [Jun. 10, 1997], 3 pp.
Database entry of Ensembl Human Genome Server, AC069205.6.1.132242, BLASTN 2.0a13MP-WashU [Jun. 10, 1997], 1 pp.
Database entry of Ensembl Human Genome Server, AC097498.3.1.144511, BLASTN 2.0a13MP-WashU [Jun. 10, 1997], 1 pp.
Database entry of Ensembl Human Genome Server, AC104785.4.111369.213599, BLASTN 2.0a13MP-WashU [Jun. 10, 1997], 1 pp.
Database entry of Ensembl Human Genome Server, AC105416.3.1.123331, BLASTN 2.0a13MP-WashU [Jun. 10, 1997], 1 pp.
Database entry of Ensembl Human Genome Server, AC108146.3.1.91810, BLASTN 2.0a13MP-WashU [Jun. 10, 1997], 1 pp.
Database entry of Ensembl Human Genome Server, AC115109.2.1.59356, BLASTN 2.0a13MP-WashU [Jun. 10, 1997], 1 pp.
Genbank entry U27809. Peanut bud necrosis virus S segment non-structural protein and nucleocapsid protein genes, Jul. 23, 1996, 3 pp.
The Sanger Centre, “Toward a Complete Human Genome Sequence”, Cold Spring Harbor Laboratory Press, 1097-1108, (1988).
Satyanarayana et al., “Peanut Bud Necrosis Tospovirus S RNA : Complete Nucleotide Sequence, Genome Organization and Homology to Other Tospoviruses”, Arch. Virol. 141 (1), 85-98 (1996).
Genbank entry AB005879. Nicotania tabacum mRNA for BYJ6, Feb. 5, 1999, 2pp.
Genbank entry AC002131. Arabidopsis thaliana chromosome 1 BAC F12F1 sequence, May 28, 1998, 38 pp.
Genbank entry AC006461. Homo sapiens BAC clone RP11-343N14 from 2, Mar. 1, 2002, 65 pp.
Genbank entry AC024028. Homo sapiens BAC clone RP11-151M24 from 7, Nov. 7, 2001, 68 pp.
Genbank entry AC069205. Homo sapiens BAC clone RP11-735P12 from 2, Jan. 9, 2002, 46 pp.
Genbank entry AC079141. Homo sapiens BAC clone RP11-502A23 from 4, Nov. 7, 2001, 43 pp.
Genbank entry AC097498. Homo sapiens BAC clone RP11-326N15 from 4, Mar. 1, 2002, 51pp.
Genbank entry AC105416. Homo sapiens BAC clone RP11-310A13 from 4, Jun. 12, 2002, 47 pp.
Genbank entry AC108146. Homo sapiens BAC clone RP11-437H3 from 2, Mar. 9, 2002, 32 pp.
Genbank entry AC115109. Homo sapiens BAC clone RP11-78I10 from 2, May 29, 2002, 23 pp.
Genbank entry AR164048. Sequence 7 from patent US 6,271,031, Oct. 17, 2001, 1 pp.
Genbank entry AR164050. Sequence 11 from patent US 6,271,031, Oct. 17, 2001, 1 pp.
Genbank entry AX344860. Sequence 285 from patent US WO0200927, Feb. 1, 2002, 4pp.
Imanishi et al., “Differential Induction by Methyl Jasmonate of Genes Encoding Ornithine Decarboxylase and Other Enzymes Involved in Nicotine Biosynthesis in Tobacco Cell Cultures”, Plant Molecular Biology, 38: 1101-1111 (1998).
Results of search of Genbank Database, BLASTN 2.2.3 [Apr. 24, 2002], RID:1026175671-06698-1397, 15pp.
Results of search of Genbank Database, BLASTN 2.2.3 [Apr. 24, 2002], RID:1026319792-012476-25945, 30pp.
Theologis et al., “Sequence and Analysis of Chromosome 1 of the Plant Arabidopsis Thaliana”, Nature, 408: 816-820 (2000).
European Search Report Application No. 04004192.3, Sep. 17, 2004.
European Search Report Application No. 04004191.5, Sep. 17, 2004.
Burtin, D., et al., Over expression of Arginine Decarboxylase in Transgenic Plants, Biochem. J., vol. 325 (Part 2), pp. 331-337 (1997).
Bush, et al., Nicotine Biosynthetic Enzymes of Burley Tobacco, Tobacco Abstracts, vol. 24, p. 260 (1980).
Bush, et al., Physiological Aspects of Genetic Variation in Nicotine Content in Tobacco (Nicotiana tabacum), Tobacco Abstract, vol. 23, p. 30 (1979).
Conkling, et al., Isolation of transcriptionally regulated root-specific genes from tobacco; Plant Physiology, vol. 93, No. 3, pp. 1203-1211 (1990).
International Search Report—date of mailing Oct. 22, 1998.
Cornelissen, et al., Both RNA Level and Translation Efficiency are Reduced by Anti-Sense RNA in Transgenic Tobacco, Nucleic Acids Res., vol. 17, No. 3., pp. 833-843 (1989).
Crowley, et al., Cell, vol. 43, pp. 633-641 (1985).
Cuozzo, et al., Viral Protection in Transgenic Tobacco Plants Expressing the Cucumber Mosaic Virus Coat Protein Or Its Antisense RNA, Biotechnology, vol. 6, pp. 549-557 (1988).
Delauney, et al., A Stable Bifunctional Antisense Transcript Inhibiting Gene Expression in Transgenic Plants, Proc. Natl. Acad. Sci. USA, vol. 85, pp. 4300-4304 (1988).
Ecker, et al., Inhibition of Gene Expression in Plant Cells by Expression of Antisense RNA, Proc. Natl. Acad. Sci. USA, vol. 83, pp. 5372-5376 (1986).
Feth, et al., Regulation in Tobacco Callus or Enzyme Activities of the Nicotine Pathway, Planta, vol. 168, pp. 402-407 1986.
Hamill, et al.; Over-expressing a yeast ornithine decarboxylase gene in transgenic roots of Nicotiana rustica can lead to enhanced nicotine accumulation, Plant Molecular Biology, vol. 15, pp. 27-38 (1990).
Hemenway, et al., Analysis of the Mechanism of Protection in Transgenic Plants Expressing the Potato Virus x Coat Protein or Its Antisense RNA, EMBO J., vol. 7, pp. 1273-1280, 1988.
Hibi, et al., Gene Expression in Tobacco Low-Nicotine Mutants, Plant Cell, vol. 6, pp. 723-735 (1994).
Holmberg, et al.; Transgenic tobacco expressing Vitreoscilla hemoglobin exhibits enhanced growth and altered metabolite production, Nature Biotechnology, vol. 15, pp. 244-247 (1997).
Hughes, Kelly T., et al., The Salmonella typhimurium nadC Gene: Sequence Determination by Use of Mud-P22 and Purification of Quinolinate Phosphoribosyltransferase, Journal of Bacteriology, vol. 175, No. 2, pp. 479-486 (Jan. 1993).
Izant, et al., Constitutive and conditional Suppression of Exogenous and Endogenous Genes by Anti-Sense RNA, Science, vol. 229, pp. 345-352 (1985).
Izant, et al., Inhibition of Thymidine Kinase Gene Expression by Anti-Sense RNA: A Molecular Approach to Genetic Analysis, Cell, vol. 36, pp. 1007-1015 (Apr. 1984).
Kim, et al., Stable Reduction of Thymidine Kinase Activity in Cells Expressing High Levels of Anti-Sense RNA, Cell, vol. 42, pp. 129-138 (Aug. 1985).
Lam, et al., Site-Specific Mutations Alter In Vitro Factor Binding and Change Promoter Expression Pattern in Transgenic Plants, Proc. Nat. Acad. Sci. USA, vol. 86, pp. 7890-7894 (1989).
Lichtenstein, Anti-sense RNA As A Tool To Study Plant Gene Expression, Nature, vol. 333, pp. 801-802 (1988).
McGarry, et al., Proc. Natl. Acad. Sci. USA (1986).
Melton, Injected Anti-Sense RNAs Specifically Block Messenger RNA Translation In Vivo, Proc. Natl. Acad. Sci. USA, vol. 82, pp. 144-148 (1985).
Mizuno, et al., A Unique Mechanism Regulating Gene Expression: Translational Inhibition By a Complementary RNA Transcript (micRNA), Trends in Genetics, vol. 1, pp. 22-25 (1985).
Ohta, et al., Metabolic Key Step Discriminating Nicotine Producing Tobacco Callus Strain From Ineffective One, Biochem. Physiol. Pflanzen, vol. 175, pp. 382-385 (1980).
Pestka, et al., Anti-mRNA: Specific Inhibition of Translation of Single mRNA Molecules, Proc. Natl. Acad. Sci. USA, vol. 81, pp. 7525-7528 (1984).
Poulsen,e t al., Dissection of 5′ Upstream Sequences for Selective Expression of the Nicotiana Plumbaginifolia rbcS-8B gene, Mol. Gen. Genet., vol. 214, pp. 16-23 (1988).
Preiss, et al., Molecular genetics of Krüppel, A Gene Required for Segmentation of the Drosphila Embryo, Plant Molecular Biology, vol. 11, pp. 463-471 (1988).
Rezaian, et al., Anti-Sense RNAs of Cucumber Mosaic Virus in Transgenic Plants Assessed For Control of the Virus, Plant Molecular Biology, vol. 11, pp. 463-471 (1988).
Rodermel, et al., Nuclear-Organelle Interactions: Nuclear Antisense Gene Inhibits Ribulose Biphosphate Carboxylase Enzyme Levels In Transformed Tobacco Plants, Cell, vol. 55, pp. 673-681 (1988).
Rosenberg, et al., Production of Phenocopies by Krüppel Antisense RNA Injection Into Drosophila Embryos, Nature, vol. 313, pp. 703-706 (1985).
Rothstein, et al., Stable and Heritable Inhibition of the Expression of Nopaline Synthase in Tobacco Expressing Antisense RNA, Proc. Natl. Sci. USA, vol. 84, pp. 8439-8443 (1987).
Sandler, et al., Inhibition of Gene Expression in Transformed Plants by Antisense RNA, Plant Molecular Biology, vol. 11, pp. 301-310 (1988).
Saunders, et al., Comparison of Nicotine Biosynthetic Enzymes in Nicotine Level Genotypes of Burley Tobacco, Agronomy Abstracts, p. 84 (1978).
Saunders, et al., Enzyme Activities in Nicotine Biosynthesis in Nicotiana Tabacum, Journal of National Products, vol. 41, p. 646, 1978.
Sheehey, et al., Reduction of Polygalacturonase Activity in Tomato Fruit by Antisense RNA; Proc. Natl. Acad. Sci. USA, vol. 85, pp. 8805-8809 (1988).
Smith, et al., Antisense RNA Inhibition of Polygalacturonase Gene Expression in Transgenic Tomatoes, Nature, vol. 334, pp. 724-726 (1988).
Song, Wen, Molecular characterizations of two tobacco root-specific genes: TobRB7 and NtQPT1(1997); UMI, Order No. DA9804246 from: Diss. Abstr. Int., B, vol. 58, No. 8, p. 4061; 224 pp. available; XP002080228.
Travers, Regulation by Anti-Sense RNA, Nature, vol. 310, p. 410 (1984).
Van der Krol, et al., An Anti-Sense Chalcone Synthase Gene in Transgenic Plants Inhibits Flower Pigmentation, Nature, vol. 333, pp. 866-869 (1988).
Van der Krol, et al., Antisense Genes in Plants; An Overview, Gene, vol. 72, pp. 45-50 (1988).
Van der Krol, et al., Modulation of Eukaryotic Gene Expression by Complementary RNA or DNA Sequences, Biotechniques, vol. 6, pp. 958-976 (1988).
Wagner, et al., Regulation in Tobacco Callus of Enzyme Activities of the Nicotine Pathway, Planta, vol. 168, pp. 408-412, 1986.
Wagner, et al., The Regulation of Enzyme Activities of the Nicotine Pathway in Tobacco, Physiol. Plantarum, vol. 68, pp. 667-672 (1986).
Wagner, Roland, et al., Determination of Quinolinic Acid Phosphoribosyl-Transferase in Tobacco, Phytochemistry, vol. 23, No. 9, pp. 1881-1883 (1884).
Weintraub, et al., Anti-sense RNA as a Molecular Tool for Genetic Analysis, Trends in Genetics, vol. 1, pp. 22-25 (1985).
West, et al., Duplex-Duplex Interactions Catalyzed by RecA Protein Allow Strand Exchanges to Pass Double-Strand Breaks in DNA, Cell, pp. 683-691 (1984).
Adams et al. “Tobacco-Specific Nitrosamine Accumulation in Different Genotypes of Burley Tobacco at Different Stages of Growth and Air-Curing” TCRC (35 pages) (1987).
Arndt et al. “Gene Regulation by Antisense RNA in the Fission Yeast Schizosaccharomyces pombe” Mol. Gen. Genet. 248:293-300 (1995).
Bourque. “Antisense Strategies for Genetic Manipulations in Plants” Plant Science 105:125-149 (1995).
Branch. “A Good Antisense Molecule is Hard to Find” TIBS 23:45-50 (1998).
Burton and Bush. “A Review on the Accumulation of Tobacco-Specific Nitrosamines in Air-Cured Tobaccos” CORESTA Meeting, Agro-Phyto Groups, Suzhou, China, Abstract AP41 (1999).
Bush et al. “Biosynthesis and Metabolism of Nicotine and Related Alkaloids” In: Nicotine and Related Alkaloids: Absorption, Distribution, Metabolism and Excretion, Eds. J.W. Gorrod and J. Wahren, Chapman & Hall, London, pp. 1-30 (1993).
Cornelissen. “Nuclear and Cytoplasmic Sites for Anti-Sense Control” Nucleic Acids Research 17(18):7203-7209 (1989).
De Lange et al. “Conditional Inhibition of β-Glucuronidase Expression by Antisense Gene Fragments in Petunia Protoplasts” Plant Molecular Biology 23:45-55 (1993).
De Roton et al. “Factors Influencing the Formation of Tobacco-Specific Nitrosamines in French Air-Cured Tobacco in Trials and at the Farm Level” Beitrage zur Tabakforschung International / Contributions to Tobacco Research 21(6):305-320 (2005).
De Roton et al. “Study of Factors Influencing the Concentration of Tobacco-Specific Nitrosamines (TSNA) in Air-Cured Tobaccos” CORESTA Congress, Lisbon, Portugal, Abstract AP4 (2000)(2 pages).
Euch et al. “Expression of Antisense Chalcone Synthase RNA in Transgenic Hybrid Walnut Microcuttings. Effect on Flavonoid Content and Rooting Ability” Plant Molecular Biology 38:467-479 (1998).
Fan et al. “Antisense Suppression of Phospholipase Dα Retards Abscisic Acid- and Ethylene-Promoted Senescence of Postharvest Arabidopsis Leaves” The Plant Cell 9:2183-2196 (1997).
Feth et al. “Regulation in Tobacco Callus of Enzyme Activities of the Nicotine Pathway” Planta 168: 402-407 (1986).
Fujisawa et al. “Suppression of the Heterotrimeric G Protein Causes Abnormal Morphology, Including Dwarfism, in Rice” PNAS USA 96:7575-7580 (1999).
Hamada et al. “Modification of Fatty Acid Composition by Over- and Antisense-Expression of a Microsomal ω-3 Fatty Acid Desaturase Gene in Transgenic Tobacco” Transgenic Research 5:115-121 (1996).
Harris. “Smoke Yields of Tobacco-Specific Nitrosamines in Relation to FTC Tar Level and Cigarette Manufacturer: Analysis of the Massachusetts Benchmark Study” Public Health Reports 116:336-343 (2001).
Hecht et al. “Environmental Carcinogens Selected Methods of Analysis. II.2 Tobacco and Tobacco Smoke (Volatile and Tobacco-Specific Nitrosamines). II.2.d Tobacco-Specific Nitrosamines in Tobacco and Tobacco Smoke” World Health Organization, International Agency for Research on Cancer, IARC Publications 45:93-101 (1983).
Hecht et al. “Environmental Carcinogens Selected Methods of Analysis. IV.6 HPLC-TEA of Tobacco Specific Nitrosamines” World Health Organization, Internaitonal Agency for Research on Cancer, IARC Publications 45:429-436 (1983).
Hecht et al. “N-Nitroso Compounds: The Metabolism of Cyclic Nitrosamines” ACS Symposium Series, 174(4):49-75 (1981).
Hempfling. “Justification of Low-Nicotine Tobacco (Lnt) Project with Calgene, Inc.” Philip Morris Collection Bates No. 2024944558 (Jun. 5, 1998)(3 pages).
Hiatt et al. “Production of Antibodies in Transgenic Plants” Nature 342:76-78 (1989).
Hoffmann et al. “Chemical Studies on Tobacco Smoke LXVIII. Analysis of Volatile and Tobacco-Specific Nitrosamines in Tobacco Products” In: N-Nitroso Compounds: Analysis, Formation and Occurrence, Eds. E.A. Walker et al. IRAC Scientific Publication No. 31, International Agency for Research on Cancer, Lyon, France, pp. 507-515 (1980).
Hoffman et al. “Environmental Carcinogens Selected Methods of Analysis. II.2. Tobacco and Tobacco Smoke (Volatile and Tobacco-Specific Nitrosamines). II.2.b Volatile Nitrosamines in Tobacco and Mainstream and Sidestream Smoke and Indoor Environments” World Health Organization, International Agency for Research on Cancer, IARC Publications 45:69-83 (1983).
Holton et al. “Cloning and Expression of Flavonol Synthase From Petunia hybrida” The Plant Journal 4(6):1003-1010 (1993).
Judelson et al. “Expression and Antisense Inhibition on Transgenes in Phytophthora infestans is Modulated by Choice of Promoter and Position Effects” Gene 133:63-69 (1993).
Kuipers et al. “Factors Affecting the Inhibition by Antisense RNA of Granule-Bound Starch Synthase Gene Expression in Potato” Mol. Gen. Genet. 246:745-755 (1995).
Kuipers et al. “Field Evaluation of Transgenic Potato Plants Expressing an Antisense Granule-Bound Starch Synthase Gene: Increase of the Antisense Effect During Tuber Growth” Plant Molecular Biology 26:1759-1773 (1994).
Legg et al. “Inheritance of Percent Total Alkaloids in Nicotiana tabacum L.” J. Hered. 60:213-217 (1969).
Loesch-Fries et al. “Cloning of Alfalfa Mosaic Virus Coat Protein Gene and Antisense RNA into Binary Vector and Their Expression in Transformed Tobacco Tissue” Molecular Strategies for Crop Protection, p. 41 (Abstract), 1986.
Mingwu. “The Source and the Regulation of Nitrogen Oxide Production for Tobacco-Specific Nitrosamine Formation During Air-Curing Tobacco” Dissertation, University of Kentucky (206 pages) (1998).
Mol et al. “Regulation of Plant Gene Expression by Antisense RNA” FEBS 268:427-430 (1990).
Murfett et al. “Antisense Suppression of S-RNase Expression in Nicotiana Using RNA Polymerase II- and III-Transcribed Gene Constructs” Plant Molecular Biology 29:201-212 (1995).
Rezaian et al. “Anti-Sense RNAs of Cucumber Mosaic Virus in Trangenic Plants Assessed for Control of the Virus” Plant Molecular Biology 11:463-471 (1988).
Saedler and Baldwin. “Virus-Induced Gene Silencing of Jasmonate-Induced Direct Defences, Nicotine and Trypsin Proteinase-Inhibitors in Nicotiana attenuata” Journal of Experimental Botany 55(395):151-157 (2004).
Schuch et al. “Control and Manipulation of Gene Expression During Tomato Fruit Ripening” Plant Molecular Biology 13:303-311 (1989).
Sessa and Fluhr. “The Expression of an Abundant Transmitting Tract-Specific Endoglucanase (Sp41) is Promoter-Dependent and Not Essential for the Reproductive Physiology of Tobacco” Plant Molecular Biology 29:969-982 (1995).
Sinclair et al. “Analysis of Wound-Induced Gene Expression in Nicotiana Species with Contrasting Alkaloid Profiles” Functional Plant Biology 31:721-729 (2004).
Sinclair et al. “Molecular Characterization of Quinolate Phosphoribosyl Transferase (QPRTase) in Nicotiana” Plant Molecular Biology 44:603-617 (2000).
Smith et al. “Inheritance and Effect on Ripening of Antisense Polygalacturonase Genes in Transgenic Tomatoes” Plant Molecular Biology 14:369-379 (1990).
Song et al. “Antisense Expression of the Peptide Transport Gene AtPTR2-B Delays Flowering and Arrests Seed Development in Transgenic Arabidopsis Plants” Plant Physiology 114:927-935 (1997).
Stepanov et al. “Tobacco-Specific Nitrosamines in New Tobacco Products” Nicotine & Tobacco Research 8(2):309-313 (2006).
Steppuhn et al. “Nicotine's Defensive Function in Nature” PLoS Biology 2(8):1074-1080 (2004).
Supplementary European Search Report, Application No. EP 01990934.0, Dated Jul. 22, 2005 (3 pages).
Theologis et al. “Use of a Tomato Mutant Constructed With Reverse Genetics to Study Fruit Ripening, a Complex Developmental Process” Developmental Genetics 14:282-295 (1993).
Tricker et al. “Topics Related to N-Nitrosamines and Their Precursors” 45th TCRC, Oct. 20-23 (1991).
Van Der Krol et al. “Inhibition of Flower Pigmentation by Antisense CHS Genes: Promoter and Minimal Sequence Requirements for the Antisense Effect” Plant Molecular Biology 14:457-466 (1990).
Voelckel et al. “Anti-Sense Expression of Putrescine N-Methyltransferase Confirms Defensive Role of Nicotine in Nicotiana sylvestris Against Manduca sexta” Chemoecology 11:121-126 (2001).
Watson et al. “Reduction of Tomato Polygalacturonase β Subunit Expression Affects Pectin Solubilization and Degradation During Fruit Ripening” The Plant Cell 6:1623-1634 (1994).
Xie et al. “Biotechnology: A Tool for Reduced-Risk Tobacco Products—The Nicotine Experience From Test Tube to Cigarette Pack” 58th Tobacco Science Research Conference, pp. 17-37 (2004).
Zhang et al. “Expression of Antisense or Sense RNA of an Ankyrin Repeat-Containing Gene Blocks Chloroplast Differentiation in Arabidopsis” The Plant Cell 4:1575-1588 (1992).
Cooke et al. EMBL-EBI No. F20096, A. Thaliana transcribed sequence, created: Mar. 5, 1996, last updated: Apr. 17, 2005. (2 pages).
* cited by examiner

Referenced By

The current document is not referenced by other documents.

Patent Family

The current document is not in a family.