Boliven Patents - US7618652: Glycosaminoglycan anticoagulants derived from fish

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US7618652: Glycosaminoglycan anticoagulants derived from fish

Filing Information

Inventor(s)	Per Olav Skjervold · Ole Rasmus Ødegaard · Frank Brosstad · Ragnar Flengsrud ·
Assignee(s)	Hepmarin AS · View assignee updates
Attorney/Agent(s)	Sughrue Mion, PLLC ·
Primary Examiner	Ruth A Davis ·
Application Number	US10472381
Filing date	03/22/2002
PCT 371 date	04/09/2004
Issue date	11/17/2009
Prior Publication Data	US20040171579 - 09/02/2004
Predicted expiration date	07/17/2022
Patent term adjustment	117
U.S. Classifications	424/520 · 424/572 · 424/550 · 424/523 ·
International Classifications	A61K3556 · A61K3560 ·
Kind Code	B2
Related U.S. Application Data	This Application is a 371 of PCT/GB02/01397, filed Mar. 22, 2002; which is a Continuation-In-Part of U.S. Provisional Application No. 60/278,418, filed Mar. 26, 2001; the disclosure of each of which is incorporated herein by reference.
PCT Application Number	WO20PCTGB0201397 - 03/22/2002
PCT Publication Number	WO2002076475 - 10/03/2002
Foreign Priority	GB0107385.7 - 03/23/2001 ·

Abstract

The present invention provides anticoagulant piscine gill glucosaminoglycans, high affinity anticoagulant piscine glycosaminoglycans anticoagulant glycosaminoglycans extractable from salmon guts, skin, tail or gills and salts and derivatives thereof.

Independent Claims | See all claims (15)

1. An isolated glucosaminoglycan having high affinity anticoagulant activity obtained from salmon gills or guts, or a salt or derivative thereof, wherein said isolated glucosaminoglycan comprises a pentasaccharide binding site for antithrombin, and wherein said isolated glucosaminoglycan contains at least one pentasaccharide unit having the sequence N-acetylglucosamine-6-O-sulfate, glucoronic acid, N-sulfated glucosamine-3,6-O-disulfate, iduronic acid 2-O-sulfate and N-sulfated glucoamine-6-O-sulfate.
2. An isolated glycosaminoglycan having high affinity anticoagulant activity obtained from salmon, or a salt or derivative thereof, wherein said isolated glycosaminoglycan comprises a pentasaccharide binding site for antithrombin, and wherein said isolated glycosaminoglycan contains at least one pentasaccharide unit having the sequence N-acetylglucosamine-6-O-sulfate, glucoronic acid, N-sulfated glucosamine-3,6-O-disulfate, iduronic acid 2-O-sulfate and N-sulfated glucoamine-6-O-sulfate.
3. An isolated glycosaminoglycan having high affinity anticoagulant activity and extracted from salmon guts, skin, tail or gills, or a salt or derivative thereof, wherein said isolated glycosaminoglycan comprises a pentasaccharide binding site for antithrombin, and wherein said isolated glycosaminoglycan contains at least one pentasaccharide unit having the sequence N-acetylglucosamine-6-O-sulfate, glucoronic acid, N-sulfated glucosamine-3,6-O-disulfate, iduronic acid 2-O-sulfate and N-sulfated glucoamine-6-O-sulfate.

References Cited

U.S. Patent Documents

Document Number	Assignees	Inventors	Issue/Pub Date
US4230699	Hepar Chimie S.A.	Fussi et al.	Oct 1980
US4438108	Akzo N.V.	Sanders et al.	Mar 1984
US4446126*	Cutter Laboratories, Inc.	Jordan	May 1984
US4533549	LASKER SIGMUND E	Lasker	Aug 1985
US4987222	Mediolanum Farmaceutici Spl	De Ambrosi et al.	Jan 1991
US6342367	Japan as represented by Secretary of Agency of Industrial Science and Technology	Sumi et al.	Jan 2002
US6491965*	Hamilton Civic Hospitals Research Development, Inc.	Berry et al.	Dec 2002
US20010036924*		Weidner	Nov 2001
US20070155652*	TANABE SEIYAKU CO., LTD.	Takigawa et al.	Jul 2007
US20070160979*		Andersson	Jul 2007

Foreign Patent Documents

Document Number	Assignees	Issue/Pub Date
EP0475383	NISSHINBO INDUSTRIES, INC.	Mar 1992
EP0509517	SEIKAGAKU KOGYO KABUSHIKI KAISHA	Oct 1992
EP0940410	FIDIA ADVANCED BIOPOLYMERS S.R.L.	Sep 1999
IT1269189	IBSA INST BIOCHIMIQUE SA	Mar 1997
JP63010601*	SEIKAGAKU KOGYO CO LTD	Jan 1988
JP02270823*		Nov 1990
WO200164756	Mitsuo TAKAI	Sep 2001

* cited by examiner

Other Publications

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Gunnar Pejler et al., “Structure and Antithrombin-binding Properties of Heparin Isolated from the Clams Anomalocardia brasiliana and Tivela mactroides”, The Journal of Biological Chemistry, 1987, 262(24): 11413-11421.

C.A.A. van Boeckel et al., “Glycosaminoglycans: Synthetic fragments and their interaction with serine protease inhibitors”, Pure & Appl. Chem., 1995, 67(10): 1663-1672.

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Dietrich et al, Biochemica et Biophysica Acta, 1428:273-283 (1999).

Vivés et al, Biochem. J., 339:767-773 (1999).