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US7618652: Glycosaminoglycan anticoagulants derived from fish

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Filing Information

Inventor(s) Per Olav Skjervold · Ole Rasmus Ødegaard · Frank Brosstad · Ragnar Flengsrud ·
Assignee(s) Hepmarin AS ·
Attorney/Agent(s) Sughrue Mion, PLLC ·
Primary Examiner Ruth A Davis ·
Application Number US10472381
Filing date 03/22/2002
PCT 371 date 04/09/2004
Issue date 11/17/2009
Prior Publication Data
Predicted expiration date 07/17/2022
Patent term adjustment 117
U.S. Classifications 424/520  · 424/572  · 424/550  · 424/523  ·
International Classifications A61K3556  · A61K3560  ·
Kind CodeB2
Related U.S. Application DataThis Application is a 371 of PCT/GB02/01397, filed Mar. 22, 2002; which is a Continuation-In-Part of U.S. Provisional Application No. 60/278,418, filed Mar. 26, 2001; the disclosure of each of which is incorporated herein by reference.
PCT Application Number WO20PCTGB0201397 - 03/22/2002
PCT Publication Number WO2002076475 - 10/03/2002
Foreign Priority GB0107385.7 - 03/23/2001 ·
15 Claims, 4 Drawings


Abstract

The present invention provides anticoagulant piscine gill glucosaminoglycans, high affinity anticoagulant piscine glycosaminoglycans anticoagulant glycosaminoglycans extractable from salmon guts, skin, tail or gills and salts and derivatives thereof.

Independent Claims | See all claims (15)

  1. 1. An isolated glucosaminoglycan having high affinity anticoagulant activity obtained from salmon gills or guts, or a salt or derivative thereof, wherein said isolated glucosaminoglycan comprises a pentasaccharide binding site for antithrombin, and wherein said isolated glucosaminoglycan contains at least one pentasaccharide unit having the sequence N-acetylglucosamine-6-O-sulfate, glucoronic acid, N-sulfated glucosamine-3,6-O-disulfate, iduronic acid 2-O-sulfate and N-sulfated glucoamine-6-O-sulfate.
  2. 2. An isolated glycosaminoglycan having high affinity anticoagulant activity obtained from salmon, or a salt or derivative thereof, wherein said isolated glycosaminoglycan comprises a pentasaccharide binding site for antithrombin, and wherein said isolated glycosaminoglycan contains at least one pentasaccharide unit having the sequence N-acetylglucosamine-6-O-sulfate, glucoronic acid, N-sulfated glucosamine-3,6-O-disulfate, iduronic acid 2-O-sulfate and N-sulfated glucoamine-6-O-sulfate.
  3. 3. An isolated glycosaminoglycan having high affinity anticoagulant activity and extracted from salmon guts, skin, tail or gills, or a salt or derivative thereof, wherein said isolated glycosaminoglycan comprises a pentasaccharide binding site for antithrombin, and wherein said isolated glycosaminoglycan contains at least one pentasaccharide unit having the sequence N-acetylglucosamine-6-O-sulfate, glucoronic acid, N-sulfated glucosamine-3,6-O-disulfate, iduronic acid 2-O-sulfate and N-sulfated glucoamine-6-O-sulfate.

References Cited

U.S. Patent Documents

Document NumberAssigneesInventorsIssue/Pub Date
US4230699 Hepar Chimie S.A. Fussi et al. Oct 1980
US4438108 Akzo N.V. Sanders et al. Mar 1984
US4446126* Cutter Laboratories, Inc. Jordan May 1984
US4533549 LASKER SIGMUND E Lasker Aug 1985
US4987222 Mediolanum Farmaceutici Spl De Ambrosi et al. Jan 1991
US6342367 Japan as represented by Secretary of Agency of Industrial Science and Technology Sumi et al. Jan 2002
US6491965* Hamilton Civic Hospitals Research Development, Inc. Berry et al. Dec 2002
US20010036924* Weidner Nov 2001
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Foreign Patent Documents

Document NumberAssigneesInventorsIssue/Pub Date
EP0475383NISSHINBO INDUSTRIES, INC.Mar 1992
EP0509517SEIKAGAKU KOGYO KABUSHIKI KAISHAOct 1992
EP0940410FIDIA ADVANCED BIOPOLYMERS S.R.L.Sep 1999
IT1269189IBSA INST BIOCHIMIQUE SAMar 1997
JP63010601*SEIKAGAKU KOGYO CO LTDJan 1988
JP02270823*Nov 1990
WO200164756Mitsuo TAKAISep 2001
* cited by examiner

Other Publications

Purificacion B. Gomes et al., “Distribution of Heparin and Other Sulfated Glycosaminoglycans in Vertebrates”, Coomp. Biochem. Physiol., 1982, 73B(4):857-863.
Peter Hovingh et al., “Biological implications of the structural, antithrombin affinity and anticoagulant activity relationships among vertebrate heparins and heparan sulphates”, Biochem. J., 1986, 237:573-581.
S.Z. Qasim et al., “Occurrence of heparin in the Blood of Fish and its Prevention of the Clotting of Fish Plasma”, Nature, 1961, 189:764-765.
Catherine Veil et al., “Sur la presence d'heparine dans les ecailles de Cyprinus carpio”, Seances Soc. Biol. Fil, 1950, 144(21-22):1483-1484.
Ganesh Venkataraman et al., “Sequencing Complex Polysaccharides”, Science, 1999, 286: 537-542.
John W. Eikelboom et al., “Low molecular weight heparins and heparinoids”, The Medical Journal of Australia, 2002, 177(6): 379-383.
Jeffrey I. Weitz, M.D., “Low-Molecular-Weight Heparins”, The New England Journal of Medicine, 1997, 337(10): 688-698.
Guilherme F. Medeiros et al., “Distribution of sulfated glycosaminoglycans in the animal kingdom: widespread occurrence of heparin-like compounds in invertebrates”, Biochimica et Biophysica Acta, 2000, 1475: 287-294.
Barbara Mulloy et al., “Order out of complexity- protein structures that interact with heparin”, Current Opinion in Structural Biology, 2001, 11: 623-628.
Matthew A. Nugent, “Heparin sequenceing brings structure to the funcction of complex oligosaccharides”, PNAS, 2000, 97(19): 10301-10303.
Gunnar Pejler et al., “Structure and Antithrombin-binding Properties of Heparin Isolated from the Clams Anomalocardia brasiliana and Tivela mactroides”, The Journal of Biological Chemistry, 1987, 262(24): 11413-11421.
C.A.A. van Boeckel et al., “Glycosaminoglycans: Synthetic fragments and their interaction with serine protease inhibitors”, Pure & Appl. Chem., 1995, 67(10): 1663-1672.
Nadar et al, Brazilian J. of Med. and Biolog. Res., 34(3):699-709, (2001).
Chavante et al, International J. of Biological Macromolecules, 27:49-57 (2000).
Dietrich et al, Biochemica et Biophysica Acta, 1428:273-283 (1999).
Vivés et al, Biochem. J., 339:767-773 (1999).

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