Boliven Patents - US7618776: Rolling circle replication reporter systems

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US7618776: Rolling circle replication reporter systems

Filing Information

Inventor(s)	Paul M. Lizardi ·
Assignee(s)	Yale University · View assignee updates
Attorney/Agent(s)	Ballard Spahr LLP ·
Primary Examiner	Carla Myers ·
Application Number	US10896513
Filing date	07/22/2004
Issue date	11/17/2009
Prior Publication Data	US20040265897 - 12/30/2004
Predicted expiration date	08/16/2016
Patent term adjustment	269
U.S. Classifications	435/6 · 435/915 · 435/912 · 435/911 ·
International Classifications	C12P1934 · C12Q168 ·
Kind Code	B2
Related U.S. Application Data	CROSS-REFERENCE TO RELATED APPLICATIONS This application is a continuation of U.S. patent application Ser. No. 10/038,718, filed on Jan. 2, 2002 now U.S. Pat. No. 6,797,474, which is a continuation of U.S. application Ser. No. 09/644,723, filed on Aug. 23, 2000 now U.S. Pat. No. 6,344,329, which is a continuation of U.S. patent application Ser. No. 09/132,553, filed Aug. 11, 1998 now U.S. Pat. No. 6,210,844, which is a continuation of U.S. patent application Ser. No. 08/563,912, filed Nov. 21, 1995 now U.S. Pat. No. 5,854,033, all of which are hereby incorporated by this reference in their entirety.

Abstract

Disclosed are compositions and a method for of amplifying nucleic acid sequences useful for detecting the presence of molecules of interest. The method is useful for detecting specific nucleic acids in a sample with high specificity and sensitivity. The method also has an inherently low level of background signal. A preferred form of the method consists of a DNA ligation operation, an amplification operation, and a detection operation. The DNA ligation operation circularizes a specially designed nucleic acid probe molecule. This operation is dependent on hybridization of the probe to a target sequence and forms circular probe molecules in proportion to the amount of target sequence present in a sample. The amplification operation is rolling circle replication of the circularized probe. A single round of amplification using rolling circle replication results in a large amplification of the circularized probe sequences. Following rolling circle replication, the amplified probe sequences are detected and quantified using any of the conventional detection systems for nucleic acids such as detection of fluorescent labels, enzyme-linked detection systems, antibody-mediated label detection, and detection of radioactive labels. Because, the amplified product is directly proportional to the amount of target sequence present in a sample, quantitative measurements reliably represent the amount of a target sequence in a sample. Major advantages of this method are that the ligation step can be manipulated to obtain allelic discrimination, the DNA replication step is isothermal, and signals are strictly quantitative because the amplification reaction is linear and is catalyzed by a highly processive enzyme. In multiplex assays, the primer oligonucleotide used for the DNA polymerase reaction can be the same for all probes. Also described are modes of the method in which additional amplification is obtained using a cascade of strand displacement reactions.

Independent Claims | See all claims (28)

1. A method comprising a DNA ligation operation and an amplification operation, wherein the DNA ligation operation comprises circularization of an open circle probe, wherein circularization of the open circle probe is dependent on hybridization of the open circle probe to a target sequence, wherein the amplification operation comprises a) rolling circle replication of the circularized open circle probe to produce tandem sequence DNA and b) secondary DNA strand displacement, wherein secondary DNA strand displacement is accomplished by hybridizing secondary DNA strand displacement primers to the tandem sequence DNA produced by the rolling circle replication of the circularized open circle probe to produce secondary tandem sequence DNA, and wherein the tandem sequence DNA as well as the secondary tandem sequence DNA is detected.
7. A method comprising a) tethering an oligonucleotide portion of a reporter binding agent to a specific binding molecule portion of the reporter binding agent, wherein the oligonucleotide portion of the reporter binding agent is an amplification target circle; and b) performing an amplification operation, wherein the specific binding molecule portion of the reporter binding agent binds to a target molecule, wherein the oligonucleotide portion of the reporter binding agent is not the target molecule, and wherein the amplification operation comprises amplification of the amplification target circle via rolling circle replication to produce tandem sequence DNA.
13. A method comprising a DNA ligation operation and an amplification operation, wherein the DNA ligation operation comprises circularization of an open circle probe, wherein circularization of the open circle probe is dependent on hybridization of the open circle probe to a target sequence, wherein the amplification operation comprises rolling circle amplification of the circularized open circle probe to produce tandem sequence DNA, wherein the tandem sequence DNA is detected, wherein rolling circle amplification is primed by a rolling circle replication primer, a secondary DNA strand displacement primer, and a tertiary DNA strand displacement primer, wherein the rolling circle replication primer and tertiary DNA strand displacement primer are complementary to the circularized open circle probe, wherein the secondary DNA strand displacement primer is complementary to sequences in the tandem sequence DNA, wherein the secondary DNA strand displacement primer is not complementary to the complement of either the rolling circle replication primer or the tertiary DNA strand displacement primer.
19. A method comprising an amplification operation, wherein a reporter binding agent and a target molecule are brought into contact, wherein the reporter binding agent comprises a specific binding molecule and an oligonucleotide, wherein the specific binding molecule interacts with the target molecule, wherein an amplification target circle and the reporter binding agent are brought into contact, wherein the amplification operation comprises rolling circle amplification of the amplification target circle to produce tandem sequence DNA, wherein the tandem sequence DNA is detected, wherein rolling circle amplification is primed by the oligonucleotide of the reporter binding agent, a secondary DNA strand displacement primer, and a tertiary DNA strand displacement primer.
24. A method comprising an amplification operation, wherein a reporter binding agent and a target molecule are brought into contact, wherein the reporter binding agent comprises a specific binding molecule and an oligonucleotide, wherein the oligonucleotide comprises an amplification target circle, wherein the specific binding molecule interacts with the target molecule, wherein the amplification operation comprises rolling circle amplification of the amplification target circle to produce tandem sequence DNA, wherein the tandem sequence DNA is detected, wherein rolling circle amplification is primed by a rolling circle replication primer, a secondary DNA strand displacement primer, and a tertiary DNA strand displacement primer, wherein the rolling circle replication primer and tertiary DNA strand displacement primer, are complementary to the amplification target circle, wherein the rolling circle replication primer and tertiary DNA strand displacement primer are not complementary to the same sequence on the amplification target circle, wherein the secondary DNA strand displacement primer is complementary to sequences in the tandem sequence DNA, wherein the secondary DNA strand displacement primer is not complementary to the complement of either the rolling circle replication primer or the tertiary DNA strand displacement primer.

References Cited

U.S. Patent Documents

Document Number	Assignees	Inventors	Issue/Pub Date
US2264423	WINGENROTH ROY L	Wingenroth	Dec 1941
US3687808	UNIV LELAND STANFORD JUNIOR	Merigan et al.	Aug 1972
US3921105	NORTHERN ELECTRIC CO	Brgetz	Nov 1975
US3983421	The Raymond Lee Organization, Inc.	Yogore	Sep 1976
US4469863	TS O PAUL O P	Ts'o	Sep 1984
US4476301	Centre National de la Recherche Scientifique	Imbach et al.	Oct 1984
US4748111	Molecular Diagnostics, Inc.	Dattagupta et al.	May 1988
US4845205	Institut Pasteur	Huynh Dinh et al.	Jul 1989
US4883750	Applied Biosystems, Inc.	Whiteley et al.	Nov 1989
US4965188	Cetus Corporation	Bertram et al.	Oct 1990
US4981957	Centre National de la Recherche Scientifique	Lebleu et al.	Jan 1991
US4984957	Ltd. Kubota	Noguchi et al.	Jan 1991
US4994373	Enzo Biochem, Inc.	Stavrianopoulos et al.	Feb 1991
US5001050	Consejo Superior Investigaciones Cientificas	Blanco et al.	Mar 1991
US5023243	Molecular Biosystems, Inc.	Tullis	Jun 1991
US5034506	Anti-Gene Development Group	Summerton et al.	Jul 1991
US5043272	Life Technologies, Incorporated	Hartley	Aug 1991
US5118800	California Institute of Technology	Smith et al.	Jun 1992
US5130238	Cangene Corporation	Malek et al.	Jul 1992
US5130302	Boron Bilogicals, Inc.	Spielvogel et al.	Jul 1992
US5134066	Monsanto Company	Rogers et al.	Jul 1992
US5166315	Anti-Gene Development Group	Summerton et al.	Nov 1992
US5175273	Genentech, Inc.	Bischofberger et al.	Dec 1992
US5177196	Microprobe Corporation	Meyer, Jr. et al.	Jan 1993
US5185444	Anti-Gene Deveopment Group	Summerton et al.	Feb 1993
US5188897	Temple University of the Commonwealth System of Higher Education	Suhadolnik et al.	Feb 1993
US5198543	Consejo Superior Investigaciones Cientificas	Blanco et al.	Mar 1993
US5214134	Sterling Winthrop Inc.	Weis et al.	May 1993
US5216141	BENNER STEVEN A	Benner	Jun 1993
US5235033	Anti-Gene Development Group	Summerton et al.	Aug 1993
US5242794	Applied Biosystems, Inc.	Whiteley et al.	Sep 1993
US5264423	The United States of America as represented by the Department of Health and Human Services	Cohen et al.	Nov 1993
US5264562	Gilead Sciences, Inc.	Matteucci	Nov 1993
US5264564	Gilead Sciences	Matteucci	Nov 1993
US5264567	Mect Corporation	Numata et al.	Nov 1993
US5273638	Beckman Instruments, Inc.	Konrad et al.	Dec 1993
US5276019	The United States of America as represented by the Department of Health and Human Services	Cohen et al.	Jan 1994
US5278302	University Patents, Inc.	Caruthers et al.	Jan 1994
US5286717	The United States of America as represented by the Department of Health and Human Services	Cohen et al.	Feb 1994
US5319080	Ciba-Geigy Corporation	Leumann	Jun 1994
US5321131	Hybridon, Inc.	Agrawal et al.	Jun 1994
US5328824	Yale University	Ward et al.	Jul 1994
US5354668		Auerbach	Oct 1994
US5359044	ISIS Pharmaceuticals	Cook et al.	Oct 1994
US5367066	Chiron Corporation	Urdea et al.	Nov 1994
US5367069	Bayer Aktiengesellschaft	Beck et al.	Nov 1994
US5393878	Ciba-Geigy Corporation	Leumann	Feb 1995
US5399676	Gilead Sciences	Froehler	Mar 1995
US5405938	Anti-Gene Development Group	Summerton et al.	Apr 1995
US5405939	Temple University of the Commonwealth System of Higher Education	Suhadolnik et al.	Apr 1995
US5409818	Cangene Corporation	Davey et al.	Apr 1995
US5412087	Affymax Technologies N.V.	McGall et al.	May 1995
US5427930	Abbott Laboratories	Birkenmeyer et al.	Jun 1995
US5429807	Beckman Instruments, Inc.	Matson et al.	Jul 1995
US5432272		Benner	Jul 1995
US5434257	Gilead Sciences, Inc.	Matteucci et al.	Jul 1995
US5443986	Molecular Probes, Inc.	Haughland et al.	Aug 1995
US5446137	Syntex (U.S.A.) Inc.	Maag et al.	Aug 1995
US5451067		Pieper	Sep 1995
US5451203	Orthopedic Systems, Inc.	Lamb	Sep 1995
US5453496	University Patents, Inc.	Caruthers et al.	Sep 1995
US5455166	Dickinson and Company Becton	Walker	Oct 1995
US5455233	University of North Carolina	Spielvogel et al.	Oct 1995
US5457187	Board of Regents University of Nebraska	Gmeiner et al.	Oct 1995
US5459255	Isis Pharmaceuticals, Inc.	Cook et al.	Oct 1995
US5466677	Ciba-Geigy Corporation	Baxter et al.	Nov 1995
US5466786	Gilead Sciences	Buhr et al.	Nov 1995
US5470967	The Dupont Merck Pharmaceutical Company	Huie et al.	Nov 1995
US5476427	Casio Computer Co., Ltd.	Fujima	Dec 1995
US5476925	Northwestern University	Letsinger et al.	Dec 1995
US5484908	Gilead Sciences, Inc.	Froehler et al.	Jan 1996
US5489677	ISIS Pharmaceuticals, Inc.	Sanghvi et al.	Feb 1996
US5502177	Gilead Sciences, Inc.	Matteucci et al.	Mar 1996
US5510270	Affymax Technologies N.V.	Fodor et al.	Apr 1996
US5514785	Becton Dickinson and Company	Van Ness et al.	May 1996
US5516134	Perfect Season, Inc.	Crawford et al.	May 1996
US5516663	Abbott Laboratories	Backman et al.	May 1996
US5519126	University of Virginia Alumni Patents Foundation	Hecht	May 1996
US5519134	Isis Pharmaceuticals, Inc.	Acevedo et al.	May 1996
US5521065	Applied Biosystems, Inc.	Whitley et al.	May 1996
US5523204	Becton Dickinson and Company	Singer et al.	Jun 1996
US5525711	The United States of America as represented by the Secretary of the Department of Health and Human Services	Hawkins et al.	Jun 1996
US5536821	Worcester Foundation for Biomedical Research	Agrawal et al.	Jul 1996
US5538871	Hoffmann-La Roche Inc.	Nuovo et al.	Jul 1996
US5539082		Nielsen et al.	Jul 1996
US5541306	Worcester Foundation for Biomedical Research	Agrawal et al.	Jul 1996
US5541307	ISIS Pharmaceuticals, Inc.	Cook et al.	Jul 1996
US5547843	Associated Universities, Inc.	Studier et al.	Aug 1996
US5550111	Temple University-Of The Commonwealth System Of Higher Education	Suhadolnik et al.	Aug 1996
US5552540	Howard Florey Institute of Experimental Physiology and Medicine	Haralambidis	Sep 1996
US5556772	Stratagene	Sorge et al.	Sep 1996
US5561225	Southern Research Institute	Maddry et al.	Oct 1996
US5563037	Johnson & Johnson Clinical Diagnostics, Inc.	Sutherland et al.	Oct 1996
US5563253	Worcester Foundation for Biomedical Research	Agrawal et al.	Oct 1996
US5563912	NEC Corporation	Yasunaga et al.	Oct 1996
US5567811	Amersham International plc	Misiura et al.	Oct 1996
US5571799	Ltd. Basco	Tkachuk et al.	Nov 1996
US5576427	Sterling Winthrop, Inc.	Cook et al.	Nov 1996
US5587361	Isis Pharmaceuticals, Inc.	Cook et al.	Dec 1996
US5587469	Isis Pharmaceuticals, Inc.	Cook et al.	Dec 1996
US5591609	Replicon, Inc.	Auerbach	Jan 1997
US5591722	Southern Research Institute	Montgomery et al.	Jan 1997
US5594121	Gilead Sciences, Inc.	Froehler et al.	Jan 1997
US5596086	Gilead Sciences, Inc.	Matteucci et al.	Jan 1997
US5596091	The Regents of the University of California	Switzer	Jan 1997
US5597909	Chiron Corporation	Urdea et al.	Jan 1997
US5599921	Stratagene	Sorge et al.	Feb 1997
US5602240	Ciba Geigy AG.	De Mesmaeker et al.	Feb 1997
US5608046	ISIS Pharmaceuticals, Inc.	Cook et al.	Mar 1997
US5610289	Isis Pharmaceuticals, Inc.	Cook et al.	Mar 1997
US5610300	Ciba-Geigy Corporation	Altmann et al.	Mar 1997
US5614389	Replicon, Inc.	Auerbach	Mar 1997
US5614390	Dickinson and Company Becton	McCaslin et al.	Mar 1997
US5614617	Isis Pharmaceuticals, Inc.	Cook et al.	Mar 1997
US5618704	ISIS Pharmacueticals, Inc.	Sanghui et al.	Apr 1997
US5623070	Isis Pharmaceuticals, Inc.	Cook et al.	Apr 1997
US5625050	Amgen Inc.	Beaton et al.	Apr 1997
US5627053	Ribozyme Pharmaceuticals, Inc.	Usman et al.	May 1997
US5629158	CEMU Bitecknik AB	Uhlen	May 1997
US5629179	Novagen, Inc.	Mierendorf et al.	May 1997
US5633360	Gilead Sciences, Inc.	Bischofberger et al.	May 1997
US5639873	Centre National de la Recherche Scientifique (CNRS)	Barascut et al.	Jun 1997
US5646265	Isis Pharmceuticals, Inc.	McGee	Jul 1997
US5648245	Carnegie Institution of Washington	Fire et al.	Jul 1997
US5658873	Degussa Aktiengesellschaft	Bertsch-Frank et al.	Aug 1997
US5663312	Sanofi	Chaturvedula	Sep 1997
US5670633	ISIS Pharmaceuticals, Inc.	Cook et al.	Sep 1997
US5677437	Isis Pharmaceuticals, Inc.	Teng et al.	Oct 1997
US5677439	Sanofi	Weis et al.	Oct 1997
US5681941	ISIS Pharmaceuticals, Inc.	Cook et al.	Oct 1997
US5700920	Novartis Corporation	Altmann et al.	Dec 1997
US5710028		Eyal et al.	Jan 1998
US5714320	University of Rochester	Kool	Feb 1998
US5714331		Buchardt et al.	Feb 1998
US5719262		Buchardt et al.	Feb 1998
US5728526	Oncor, Inc.	George et al.	Mar 1998
US5733733	Replicon, Inc.	Auerbach	Mar 1998
US5766891	Sloan-Kettering Institute for Cancer Research	Shuman	Jun 1998
US5795714	Trustees of Boston University	Cantor et al.	Aug 1998
US5821084	The Regents of the University of Michigan	Olmsted et al.	Oct 1998
US5854033	Yale University	Lizardi	Dec 1998
US5854053	Ecogen, Inc.	Donovan et al.	Dec 1998
US5866329		Demetriou et al.	Feb 1999
US5866336	Oncor, Inc.	Nazarenko et al.	Feb 1999
US5871921		Landgren et al.	Feb 1999
US5874260	Bio Merieux	Cleuziat et al.	Feb 1999
US5876924	Mount Sinai School of Medicine	Zhang et al.	Mar 1999
US5909132		Trofimenkoff et al.	Jun 1999
US5925517	The Public Health Research Institute of the City of New York, Inc.	Tyagi et al.	Jul 1999
US5942391	Mount Sinai School of Medicine	Zhang et al.	Aug 1999
US5985639	Henkel Kommanditgesellschaft auf Aktien	Christianson et al.	Nov 1999
US6008373	Carnegie Mellon University	Waggoner et al.	Dec 1999
US6017703	Bard Diagnostic Sciences, Inc.	Kinders et al.	Jan 2000
US6033881		Himmler et al.	Mar 2000
US6037130	The Public Health Institute of the City of New York, Inc.	Tyagi et al.	Mar 2000
US6054274	Hewlett-Packard Company	Sampson et al.	Apr 2000
US6057105	NGI/Cancer Tech Company, LLC	Hoon et al.	May 2000
US6077668	University of Rochester	Kool	Jun 2000
US6077674	Agilent Technologies Inc.	Schleifer et al.	Jun 2000
US6096880	University of Rochester	Kool et al.	Aug 2000
US6117635	Intergen Company	Nazarenko et al.	Sep 2000
US6124120	Yale University	Lizardi	Sep 2000
US6132728	The Johns Hopkins University School of Medicine	Beachy et al.	Oct 2000
US6143495*	Yale University	Lizardi et al.	Nov 2000
US6183960	Yale University	Lizardi	Feb 2001
US6203984	Pacron, Inc.	Hu et al.	Mar 2001
US6210884*	Yale University	Lizardi	Apr 2001
US6214587	Gen-Probe Incorporated	Dattagupta et al.	Apr 2001
US6221603	Molecular Dynamics, Inc.	Mahtani et al.	Apr 2001
US6235502	Molecular Staging Inc.	Weissman et al.	May 2001
US6248535	University of Southern California	Danenberg et al.	Jun 2001
US6255082	Yale University	Lizardi et al.	Jul 2001
US6274320	CuraGen Corporation	Rothberg et al.	Aug 2001
US6277607		Tyagi et al.	Aug 2001
US6280949	Yale University	Lizardi	Aug 2001
US6287768	Clontech Laboratories, Inc.	Chenchik et al.	Sep 2001
US6287776	Signature BioScience, Inc.	Hefti	Sep 2001
US6287824	Yale University	Lizardi	Sep 2001
US6288220	Hitachi, Ltd.	Kambara et al.	Sep 2001
US6291187	Molecular Staging, Inc.	Kingsmore et al.	Sep 2001
US6291193	Millennium Pharmaceuticals, Inc.	Khodadoust	Sep 2001
US6291669		Kwiatkowski et al.	Sep 2001
US6294664	Isis Pharmaceuticals, Inc.	Ravikumar et al.	Sep 2001
US6297006	Hyseq, Inc.	Drmanac et al.	Oct 2001
US6312902	Promega Corporation	Shultz et al.	Nov 2001
US6316229	Yale University	Lizardi et al.	Nov 2001
US6323009	Molecular Staging, Inc.	Lasken et al.	Nov 2001
US6329150	Yale University	Lizardi et al.	Dec 2001
US6344329	Yale University	Lizardi	Feb 2002
US6355431	Illumina, Inc.	Chee et al.	Mar 2002
US6365729	The Public Health Research Institute of the city of New York, Inc.	Tyagi et al.	Apr 2002
US6368801	Molecular Staging, Inc.	Faruqi	Apr 2002
US6403319	Yale University	Lizardi et al.	Jun 2002
US6440707	Washington University	Kwok et al.	Aug 2002
US6458544	DNA Sciences, Inc.	Miller	Oct 2002
US6472185	Pioneer Hi-Bred International, Inc.	McCasky Feazel et al.	Oct 2002
US6475736	Variagenics, Inc.	Stanton	Nov 2002
US6479242	Cleveland State University	Guo et al.	Nov 2002
US6479244	Galileo Genomics	Belouchi et al.	Nov 2002
US6498023	Molecular Staging, Inc.	Abarzua	Dec 2002
US6531283	Molecular Staging, Inc.	Kingsmore et al.	Mar 2003
US6573051	Molecular Staging, Inc.	Alsmadi et al.	Jun 2003
US6617137	Molecular Staging Inc.	Dean et al.	Sep 2003
US6632609	Yale University	Lizardi	Oct 2003
US6635425	Molecular Staging, Inc.	Bandaru et al.	Oct 2003
US6670126	Molecular Staging, Inc.	Kingsmore et al.	Dec 2003
US6686157	Molecular Staging Inc.	Ward et al.	Feb 2004
US6703228	Massachusetts Institute of Technology	Landers et al.	Mar 2004
US6703885	Richtek Technology Corp.	Fan et al.	Mar 2004
US6713257	Rosetta Inpharmatics LLC	Shoemaker et al.	Mar 2004
US6777183	Molecular Staging, Inc.	Abarzua	Aug 2004
US6797474*	Yale University	Lizardi	Sep 2004
US6811986	Molecular Staging, Inc.	Bandaru et al.	Nov 2004
US6830884	Molecular Staging Inc.	Hafner et al.	Dec 2004
US6861222	Yale University	Ward et al.	Mar 2005
US6921642	QLAGEN GmbH	Kingsmore et al.	Jul 2005
US6977153	Qiagen GmbH	Kumar et al.	Dec 2005
US7041480	Qiagen GmbH	Abarzua	May 2006
US20010041340		Kingsmore et al.	Nov 2001
US20020009716		Abarzua	Jan 2002
US20020119465		Zhao et al.	Aug 2002
US20020120409	Affymetrix, INC.	Cao et al.	Aug 2002
US20020192649	Yale University	Lizardi	Dec 2002
US20020192658		Ward et al.	Dec 2002
US20020197694		Shao	Dec 2002
US20030008313		Whitshire	Jan 2003
US20030022167		Alsmadi et al.	Jan 2003
US20030032024	Yale University	Lizardi	Feb 2003
US20030044794	Bandaru and Kumar	Bandaru et al.	Mar 2003
US20030143613		Kingsmore et al.	Jul 2003
US20030152932		Kumar et al.	Aug 2003
US20030165948		Alsmadi	Sep 2003
US20030175788		Alsmadi	Sep 2003
US20030207267		Lasken et al.	Nov 2003
US20030207323		Bandaru et al.	Nov 2003
US20030235849		Lizardi	Dec 2003
US20040091857		Nallur et al.	May 2004
US20040121338		Alsmadi et al.	Jun 2004
US20040126770		Kumar et al.	Jul 2004
US20040191784		Abarzua et al.	Sep 2004
US20040248103		Feaver et al.	Dec 2004
US20050079523		Hafner et al.	Apr 2005
US20060166227	KINGSMORE STEPHEN	Kingsmore et al.	Jul 2006
US20060188893		Kumar et al.	Aug 2006

Foreign Patent Documents

Document Number	Assignees	Issue/Pub Date
AU649066	SYNGENE INC	May 1994
AU714486	UNIV YALE	Apr 2000
EP0070685	AMOCO CORPORATION	Jul 1982
EP0128332	ENZO BIOCHEM, INC.	Dec 1984
EP0356021	ZENECA LIMITED	Feb 1990
EP0439182	ABBOTT LABORATORIES	Jul 1991
EP0466520	LIFE TECHNOLOGIES INC.	Jan 1992
EP0505012	F. HOFFMANN-LA ROCHE AG	Sep 1992
EP0667393	ENZO DIAGNOSTICS, INC.	Aug 1995
EP0678582	Dickinson and Company Becton	Oct 1995
EP0745690	THE PUBLIC HEALTH RESEARCH INSTITUTE	Dec 1996
EP0756009	Laboratory of Molecular Biophotonics	Jan 1997
GB2332516	HEWLETT PACKARD CO	Jun 1999
JP04304900*	TOYOBO CO LTD	Oct 1992
WO199108307		Jun 1991
WO199201813		Feb 1992
WO199416108		Jul 1994
WO199424312		Oct 1994
WO199503430		Feb 1995
WO199503432		Feb 1995
WO199522623		Feb 1995
WO199525180		Sep 1995
WO199535390		Dec 1995
WO199633207		Oct 1996
WO199717076		May 1997
WO199717471		May 1997
WO199719193		May 1997
WO199720948		Jun 1997
WO199742346		Nov 1997
WO199804746		Feb 1998
WO199918241		Apr 1999
WO199931276		Jun 1999
WO200004193	YALE UNIVERSITY	Jan 2000
WO200015779	YALE UNIVERSITY	Mar 2000
WO200036141	DIATECH PTY. LTD.	Jun 2000
WO200071562	THE PUBLIC HEALTH RESEARCH INSTITUTE OF THE CITY OF NEW YORK, INC.	Nov 2000
WO200140516	MOLECULAR STAGING INC.	Jun 2001
WO200161037	Ulf LANDEGREN	Aug 2001
WO200164952	MOLECULAR STAGING, INC.	Sep 2001
WO200177390		Oct 2001
WO200179420	MOLECULAR STAGING, INC.	Oct 2001
WO200188190	MOLECULAR STAGING, INC.	Nov 2001
WO200197616	MOLECULAR STAGING, INC.	Dec 2001
WO200200934	MOLECULAR STAGING, INC.	Jan 2002
WO200202792	MOLECULAR STAGING, INC.	Jan 2002
WO2002053780	MOLECULAR STAGING, INC.	Jul 2002
WO2002077256	MOLECULAR STAGING, INC.	Oct 2002
WO2002103058	MOLECULAR STAGING, INC.	Dec 2002
WO2003008538	MOLECULAR STAGING, INC.	Jan 2003
WO2003066908	MOLECULAR STAGING, INC.	Aug 2003
WO2004061119	MOLECULAR STAGING, INC.	Jul 2004

* cited by examiner

Other Publications

Ausubel et al. Current Protocols in Molecular Biology, John Wiley & Sons, 1:1.6.1-1.6.6 (1988).

Barbato et al. Solid Phase Syntheses of Cyclic Oligodeoxyribonucleotides. Tetrahedron Letters. 28(46):5727-2728 (1987).

Bryant et al. Phosphorothioate substrates for T4 RNA ligase. Biochemistry. 21(23):5877-5885 (1982).

Capobianco et al. One pot solution synthesis of cyclic oligodeoxyribonucleotides. Nucleic Acids Research; 18(9):2661-2669 (1990).

Cheung et al. Whole genome amplification using a degenerate oligonucleotide primer allows hundreds of genotypes to be performed on less than one nanogram of genomic DNA. Proc Natl Acad Sci USA. 93:14676-14679 (1996).

Christian et al. Detection of DNA point mutations and mRNA expression levels by rolling circle amplification in individual cells. Proc Natl Acad Sci U S A. 98(25):14238-14243. Epub Nov. 27, 2001 (Dec. 4, 2001).

Cummins et al. Biochemical and physicochemical properties of phosphorodithioate DNA. Biochemistry. 35(26):8734-8741 (1996).

de Vroom et al. Syntheses of cyclic oligonucleotides by a modified phosphotriester approach. Nucleic Acids Research. 16(10):4607-4620 (1988).

Diegelman et al. Generation of circular RNAs and trans-cleaving catalytic RNAs by rolling transcription of circular DNA oligonucleotides encoding hairpin ribozymes. Nucleic Acids Res. 26(13):3235-3241 (1998).

Doherty et al. Structural and mechanistic conservation in DNA ligases. Survey and Summary. Nucleic Acids Res. 28(21):4051-4058 (2000).

Dolinnaya et al. Oligonucleotide circularization by template-directed chemical ligation. Nucleic Acids Res. 21(23):5403-5407 (1993).

Eckstein et al. Phosphorothioates in molecular biology. Trends in Bioch Sci. 14:97-100 (1989).

Erie et al. Melting Behavior of a Covalently Closed, Single-Stranded, Circular DNA. Biochemistry. 28:268-273. (1989).

Faruqi et al. High-throughput genotyping of single nucleotide polymorphisms with rolling circle amplification. BMC Genomics 2(4) (2001).

Gryaznov et al. Template controlled coupling and recombination of oligonucleotide blocks containing thiophosphoryl groups. Nucleic Acids Res. 21(6):1403-1408 (1993).

Haff et al. Single-nucleotide polymorphism identification assays using a thermostable DNA polymerase and delayed extraction MALDI-TOF mass spectrometry. Genome Res. 7(4):378-388 (1997).

lshikawa et al. Sequence-based typing of HLA-A2 alleles using a primer with an extra base mismatch. Hum Immunol. 42(4):315-318 (1995).

James et al. Surprising fidelity of template-directed chemical ligation of oligonucleotides. Chemistry & Biology. 4:595-605 (1997).

Kanaya et al. Template-Directed Polymerization of Oligoadenylates Using Cyanogen Bromide. Biochemistry. 25:7423-7430 (1986).

Kinoshita et al. Strand Ligation in a double-stranded DNA by T4 RNA Ligase. Chemistry Letters. 797-798 (1996).

Kricka. Ultrasensitive immunoassay techniques. Clin Biochem. 26(5):325-331 (1993).

Lyons et al. Immunosuppressant FK506 promotes neurite outgrowth in cultures of PC12 cells and sensory ganglia. Proc Natl Acad Sci U S A. 91(8):3191-3195 (1994).

Marshall et al. A biopolymer by any other name would bind as well: a comparison of the ligand-binding pockets of nucleic acids and proteins. Structure. 5(6):729-734. (1997).

Navarro et al. A general strategy for cloning viroids and other small circular RNAs that uses nminimal amounts of template and does not require prior knowledge of its sequence. J Virol Meth. 56:59-66 (1996).

Nilsson et al. Real-time monitoring of rolling-circle amplification using a modified molecular beacon design. Nucleic Acids Res. 30(14):e66 (2002).

Prakash et al. Molecular Recognition by Circular Oligonucleotides. Strong Binding of Single-Stranded DNA and RNA. J Chem Soc, Chem Commun. 1161-1163 (1991).

Reese et al. The H-phosphonate approach to the solution phase synthesis of linear and cyclic oligoribonucleotides. Nucleic Acids Research. 27(4):963-971 (1999).

Rossi et al. Functional characterization of the T4DNA ligase: a new insight into the mechanism of action. Nucleic Acids Res. 25(11):2106-2113 (1997).

Rubin et al. Convergent DNA synthesis: a non-enzymatic diverization approach to circular oligodeoxynucleotides. Nucleic Acids Res. 23(17):3547-3553 (1995).

Schenk et al. The accessibility of thiophosphorylated groups in DNA fragments to the enzymatic activity of ligases and restriction endonuclease Bbs 1. Biochem Mol Biol Int. 36(5):1037-1043 (1995) Abstract.

Skerra. Phosphorothioate primers improve the amplification of DNA sequences by DNA polymerases with proofreading activity. Nucleic Acids Res. 20(14):3551-3554 (1992).

Stratagene Catalog, p. 39 (1988).

Stratagene Catalog, p. 76 (1992).

Strong et al. Marked improvement of PAC and BAC cloning is achieved using electroelution of pulsed-field gel-separated partial digests of genomic DNA. Nucleic Acids Res. 25(19):3959-3961 (1997).

Unrau et al. Non-cloning amplification of specific DNA fragments from whole genomic DNA digests using DNA ‘indexers’. Gene. .145(2):163-169 (1994).

Welford et al. Detection of differentially expressed genes in primary tumor tissues using representational differences analysis coupled to microarray hybridization. Nucleic Acids Res. 26(12):3059-3065 (1998).

Wemmer et al. Preparation and melting of single strand circular DNA loops. Nucleic Acids Res. 13(23):8611-8621 (1985).

White et al. Concatemer chain reaction: a Taq DNA polymerase-mediated mechanism for generating long tandemly repetitive DNA sequences. Anal Biochem. 199(2):184-190 (1991).

Wilson et al. Enzyme complex amplification—a signal amplification method for use in enzyme immunoassays. Anal Biochem. 209(1):183-187 (1993).

Xu et al. Nonenzymatic autoligation in direct three-color detection of RNA and DNA point mutations. Nature Biotechnology. 19:148-152 (2001).

Yang et al. Combining SSH and cDNA microarrays for rapid identification of differentially expressed genes. Nucleic Acids Res. 27(6):1517-1523 (1999).

AAAI Board of Directors. Measurement of specific and nonspecific IgG4 levels as diagnositc and prognostic tests for clinical allergy. J Allergy Clin Immunol. 95:652-654 (1995).

Anderson et al. A comparison of selected mRNA and protein abundances in human liver. Electrophoresis. 18:533-537 (1997).

Beaucage et al. Deoxynucleoside phosphoramidites—a new class of key intermediates for deoxypolynucleotide synthesis. Tetrahedron Lett. 22(20):1859-1862(1981).

Bonnet et al. Thermodynamic basis of the enhanced specificity of structured DNA probes. Proc Natl Acad Sci USA. 96(11):6171-6176 (1999).

Brush. Dye hard: protein gel staining products. The Scientist. 12:16-22 (1998).

Chang. The pharmacological basis of anti-IgE therapy. Nat Biotech. 18:157-162 (2000).

Colantuoni et al., Gene expression profiling in postmortem Rett Syndrome brain: differential gene expression and patient classification. Neurobiol. Dis. 8(5):847-865 (2001).

Colantuoni et al., High throughput analysis of gene expression in the human brain. J. Neurosci. Res. 59(1):1-10 (2000).

Craxton et al. Linear Amplification Sequencing, a Powerful Method for Sequencing DNA. Meth. Compan. Meth. Enzymol. 3(1):20-26 (Aug. 1991).

Crooke et al. Pharmacokinetic properties of several novel oligonucleotide analogs in mice. J Pharmacol Exp Ther. 277(2):923-937 (1996).

Dean et al. Rapid Amplification of Plasmid and Phage DNA Using Phi29 DNA Polymerase and Multiply-Primed Rolling Circle Amplification. Genome Res. 11:1095-1099 (2001).

Ekins. Ligand assays: from electrophoresis to miniaturized microarrays. Clin Chem. 44(9):2015-2030 (1998).

Englisch et al. Chemically modified oligonucleotides as probes and inhibitors. Angewandte Chemie, Intl Ed. 30(6):613-629 (1991).

Fields et al. How many genes in the human genome? Nat Genet. 7:345-346 (1994).

Fleischmann et al. Whole-genome random sequencing and assembly of haemophilus influenza Rd. Science. 269:496-512 (1995).

Gait. Oligonucleotides. Antisense Research and Applications. (Crooke et al, eds., CRC Press) Chapter 16; pp. 289-301 (1993).

Guatelli et al. Isothermal, in vitro amplification of nucleic acids by a multienzyme reaction molded after retroviral replication. Proc. Natl. Acad. Sci. USA 87:1874-1878 (1990).

Gygi et al. Correlation between protein and mRNA abundance in yeast. Mol Cell Biol. 19(3):1720-1730 (1999).

Hall et al. Nucleotides. Part XLI. Mixed anhydrides as intermediates in the synthesis of dinucleoside phosphates. J Chem Soc. 3291-3296 (1957).

Hall et al. Sensitive detection of DNA polymorphisms by the serial invasive signal amplification reaction. Proc. Natl. Acad. Sci. USA 97(15):8272-8277 (Jul. 2000).

Heinonen et al. Simple triple-label detection of seven cystic fibrosis mutations by time-resolved fluorometry. Clin Chem. 43(7):1142-1150 (1997).

Henegariu et al. Custom flourescent-nucleotide synthesis as an alternative method for nucleic acid labeling. Nat Biotech. 18:345-348 (2000).

Hermanson et al., eds. Immobilized Affinity Ligands. (Academic Press, NY, 1992).

Hoeltke et al. Multiple nucleic acid labeling and rainbow detection. Anal Biochem. 207:24-31 (1992).

Holland et al., Detection of Specific Polymerase Chain Reaction Product by Utilizing the 5′→3′ Exonuclease Activity of Thermus aquaticus DNA Polymerase. Proc. Natl. Acad. Sci. USA 88:7276-7280 (Aug. 1991).

Humphery-Smith et al. Proteome analysis: genomics via the output rather than the input code. J Protein Chem. 16(5):537-544 (1997).

Iyer et al. 3-H-1,2-benzodithiole-3-one 1, 1-dioxide as an improved sulfurizing reagent in the solid-phase synthesis of oligodeoxyribonudeosdie phosphorothioates. J Am Chem Soc. 112:1253-1254 (1990).

Jiang et al. An efficient method for generation and subcloning of tandemly repeated DNA sequences with defined length, orientation and spacing. Nucl. Acids Res. 24(16):3278-3279 (1996).

Johnstone and Thorpe, Immunochemistry in Practice, Blackwell Scientific Publications, Oxford, England, pp. 30-85 (1987).

Jonsson et al. Sequence of the DNA ligase-encoding gene from Thermus scotoductus and conserved motifs in DNA ligases. Gene. 151:177-180 (1995).

Kabanov et al. A new class of antivirals: antisense oligonucleotides combined with a hydrophobic substituent effectively inhibit influenze virus reproduction and synthesis of virus-specific proteins in MDCK cells. FEBS Lett. 259(2):327-330 (1990).

Kessler. The digoxigenin:anti-dioxgenin (DIG) technology—a survey on the concept and realization of a novel bioanalytical indicator system. Mol Cell Probes. 5:161-205 (1991).

Kimpton et al. Automated DNA profiling employing multiplex amplification of short tandem repeat loci. PCR Methods and Applications. 3(1):13-22 (1993).

Kool. Circular oligonucleotides: new concepts in oligonucleotide design. Annual Rev Biomol Strict. 25:1-28 (1996).

Kwoh et al. Transcription-based amplification system and detection of amplified human immunodeficiency virus type 1 with a bead-based sandwich hybridization format. Proc. Natl. Acad. Sci. USA 86:1173-1177 (1989).

Letsinger et al. Cholesteryl-conjugated oligonucleotides: synthesis, properties, and activity as inhibitors of replication of human immunodeficiency virus in cell culture. Proc Natl Acad Sci USA. 86:6553-6556 (1989).

Letsinger et al. Synthesis of thymidine oligonucleotides by phosphite triester intermediates. J Am Chem Soc. 98(12):3655-3661 (Jun. 9, 1976).

Letsinger et al. Use of a stilbenedicarboxamide bridge in stabilizing, monitoring, andn photochemically altering folded conformations of oligonucleotides. J Am Chem Soc. 117(28):7323-7328 (1995).

Lichter et al. High-resolution mapping of human chromosome 11 by in situ hybridization with cosmid clones. Science. 247:64-69 (1990).

Little, Strand Displacement Amplification and Homogeneous Real-Time Detection Incorporated in a Second-Generation DNA Probe System, BDProbeTecET. Clin. Chem. 45:777-784 (1999).

Lizardi et al. Cascade rolling circle amplification, a homogeneous fluorescence detection system for DNA diagnostics. Clinical Chemistry 43(11):2219-2220 (1997).

Manoharan et al. Chemical modifications to improve uptake and bioavailability of antisense oligonucleotides. Ann NY Acad Sci. 660:306-309 (1992).

Manoharan et al. Cholic acid-oligonucleotide conjugates for antisense applications. Bioorg Med Chem Let. 4(8):1053-1060 (1994).

Manoharan et al. Introduction of a lipophilic thioether tether in the minor groove of nucleic acids for antisense applications. Bioorg Med Chem Let. 3(12):2765-2770 (1993).

Manoharan et al. Lipidic nucleic acids. Tetra Lett. 36(21):3651-3654 (1995).

Manoharan et al. Oligonucleotide conjugates: alteration of the pharmacokinetic properties of antisense agents. Nucleosides & Nucleotides. 14:969-973 (1995).

Matteucci et al. Synthesis of deoxyoligonucleotides on a polymer support. J Am Chem Soc. 103:3185-3191 (1981).

Mendoza et al. “High-Throughput Microarray-Based Enzyme-Linked Immunosorbent Assay (ELISA)” BioTechniques. vol. 27(4):778-788 (1999).

Nallur et al., Signal amplification by rolling circle amplification on DNA microarrays. Nucl. Acids Res. 29:E118 (2001).

Nazerenko et al. A closed tube format for amplification and detection of DNA based on energy transfer. Nucl. Acids Res. 25:2516-2521 (Jun. 1997).

Nichols et al. A universal nucleoside for use at ambiguous sites in DNA primers. Nature. 369(6480):492-493 (1994).

Nielsen. Sequence-selective recognition of DNA by strand displacement with a thymine-substituted polyamide. Science. 254:1497-1500 (1991).

Oberhauser et al. Effective incorporation of 2′-o-methyl-oligoribonucleotides into liposomes and enhanced cell association through modification with thiocholesterol. Nucl Acids Res. 20(3):533-538 (1992).

Oda et al. Accurate quantitation of protein expression and site-specific phosphorylation. Proc Natl Acad Sci USA. 96:6591-6596 (1999).

Parker et al. Targeted gene walking polymerase chain reaction. Nucl Acids Res. 19:3055-3060 (1991).

Patton et al. Components of the protein synthesis and folding machinery are induced in vascular smooth muscle cells by hypertrophic and hyperplastic agents. J Biol Chem. 270(36):21404-21410 (1995).

Patton. Making blind robots see: the synergy between flourescent dyes and imaging devices in automated proteomics. Biotechniques. 28:944-957 (2000).

Patton. Proteome analysis II. Protein subcellular redistribution: linking physiology to genomics via the proteome and separation techniques involved. J Chromatogr. 722:203-223 (1999).

Pless et al. Solid support synthesis of oligothymidylates using phosphorochloridates and 1-alkylmidazoles. Nucl Acids Res. 2(6):773-786 (1975).

Porstmann et al. Quantitation of 5-bromo-2-deoxyuridine incorporation into DNA: an enzyme immunoassay for the assessment of the lymphoid cell proliferative response. J Immunol Meth. 82:169-179 (1985).

Prober et al. A system for rapid DNA sequencing with fluorescent chain-terminating dideoxynucleotides, Science. 238:336-341 (1987).

Protein immobilization: fundamentals and applications, Richard F. Taylor, ed. (M. Dekker, New York, 1991).

Ramsing et al. Helix-coil transition of parallel-stranded DNA. Thermodynamics of hairpin and linear duplex oligonucleotides. Biochem. 28:9528-9535 (1989).

Saiki et al. Enzymatic Amplifications of β-Globin Genomic Sequences and Restiction Site Analysis for Diagnosis of Sickle Cell Anemia. Science 230:1350-1354 (1985).

Saiki et al. Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase. Science 239:487-491 (Jan. 29, 1988).

Saison-Behmoaras et al. Short modified antisense oligonucleotides directed against Ha-ras point mutation induce selective cleavage of the mRNA and inhibit T24 cells proliferation. EMBO J. 10(5)1111-1118 (1991).

Sanghvi. Heterocyclic base modifications in nucleic acids and their applications in antisense oligonucleotides. Antisense Research and Applications. (Crooke et al, eds., CRC Press) Chapter 15; pp. 273-288 (1993).

Sano et al. Detection of heavy methylation in human repetitive DNA subsets by a monoclonal antibody against 5-methylcytosine. Biochim Biophys Acta. 951:157-165 (1988).

Schena et al. “DNA Microarrays: A Practical Approach” (Oxford University Press, New York, 1999) 1-16.

Schweitzer and Kingsmore. Combining nucleic acid amplification and detection. Curr. Opin. Biotech. 12(1):21-27 (Feb. 2001).

Shea et al. Synthesis, hybridization properties and antiviral activity of lipid-oligodeoxynucleotide conjugates. Nucl Acids Res. 18(13)3777-3783 (1990).

Shumaker et al. Mutation detection by solid phase primer extension. Human Mutation. 7(4):346-354 (1996).

Silzel et al. “Mass-sensing, Multianalyte Microarray Immunoassay with Imaging Detection” Clin. Chem. 44: 2036-2043 (1998).

Simpson. The natural somatic mutation frequency and human carcinogenesis. Adv Cancer Res. 71:209-240 (1997).

Speicher et al. Karyotyping human chromosomes by combinatorial multi-fluor FISH. Nature Genetics. 12(4):368-375 (1996).

Stimpson et al. Real-time detection of DNA hybridization and metling on oligonudeotide arrays by using optical wave guides. Proc Natl Acad Sci USA. 92(14):6379-6383 (1995).

Strauss et al. Quantitative measurement of calretinin and β-actin mRNA in rat brain micropunches without prior isolation of RNA. Mol Brain Res. 20:229-239 (1993).

Studier et al. Use of T7 RNA polymerase to direct expression of cloned genes. Methods in Enzymology. 185:60-89 (1990).

Stump et al., Tthe use of modified primers to eliminate cycle sequencing artifacts. Nucl. Acids Res. 27:4642-4648 (1999).

Svinarchuk et al. Inhibition of HIV proliferation in MT-4 cells by antisense oligonucleotide conjugated to lipophilic groups. Biochimie. 75:49-54 (1993).

Syvanen et al. Fast quantification of nucleic acid hybrids by affinity-based hybrid collection. Nucleic Acids Research. 14(12):5037-5048 (1986).

Tabor et al. Selective inactivation of the exonuclease activity of bacteriohage.T7 DNA polymerase by in Vitro Mutagenesis. J Biol Chem. 264(11):6447-6458 (1989).

Tabor et al. Selective oxidation of the exonuclease domain of bacteriophage T7 DNA polymerase. J Biol Chem. 262:15330-15333 (1987).

Thelwell et al. Mode of action and application of Scorpion primers to mutation detection. Nucl. Acids Res. 28(19):3752-3761 (2000).

Thomas et al. Cascade rolling circle amplification, a homogenous fluorescence detection system for DNA diagnostics. Clin Chem. 43:2219, Abs. 38 (1997).

Thorbjarnardottir et al. Cloning and sequence analysis of the DNA Iligase-encoding gene of Rhodothermus marinus, and overproduction, purification and characterization of two thermophilic DNA ligases. Gene 161:1-6 (1995).

Tsurumi et al. Functional interaction between Epstein-Barr virus DNA polymerase catalytic subunit and its accessory subunit in vitro. Journal of Virology. 67(12):7648-7653 (1993).

Tyagi et al. Extremely sensitive, background-free gene detection using binary probes and Qβ replicase. Proc. Natl. Acda. Sci. USA 93:5395-5400 (1996).

Uemori et al., Cloning of the DNA polymerase gene of Bacillus caldotenax and characterization of the gene product. J. Biochem. 113(3):401-410 (Mar. 1993).

Velculescu et al. Serial analysis of gene expression. Science. 270:484-487 (1995).

Villemain et al. The N-terminal B-domain of T4 gene 32 protein modulates the lifetime of cooperatively bound Gp32-ss nucleic acid complexes. Biochemistry. 35:14395-14404 (1996).

Voisey et al. Interrogation of multimeric DNA amplification products by competitive primer extension using bst DNA polymerase (large fragment). Biotechniques. 31(5):1122-1129 (2001).

Vogelstein et al. Supercoiled loops and eucaryotic DNA replication. Cell. 22:79-85 (1980).

Waggoner. Covalent labeling of proteins and nucleic acids with fluorophores. Meth Enzymology. 246:362-373 (1995).

Walker et al. Detection of mycobacterium tuberculosis DNA with thermophilic strand displacement amplification and fluorescence polarization. Clin Chem. 42(10):1604-1608 (1996).

Walker et al. Isothermal in vitro amplification of DNA by a restriction enzyme/DNA polymerase system. Proc Natl Acad Sci USA. 89:392-396 (1992).

Walker et al. Strand displacement amplification—an isothermal, in vitro DNA amplification technique. Nucleic Acids Research. 20(7):1691-1696 (1992).

Walter et al. Strand displacement amplification as an in vitro model for rolling-circle replication: deletion formation and evolution during serial transfer. Proc Natl Acad Sci USA. 91:7937-7941 (1994).

Wang et al. Circular RNA oligonucleotides. Synthesis, nucleic acid binding properties, and a comparison with circular DNAs. Nucl. Acids Res. 22(12):2326-2333 (1994).

Wang et al. Large-scale identification, mapping, and genotyping of single-nucleotide polymorphisms in the human genome. Science. 280:1077-1082 (1998).

Wansink et al. Fluorescent labeling of nascent RNA reveals transcription by RNA polymerase II in domains scattered throughout the nucleus. Journal of Cell Biology. 122(2):283-293 (1993).

Wiedmann et al. Ligase chain reaction (LCR)—overview and applications. PCR Methods and Applications. (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 1994) [pp. S51-S64].

Winn-Deen et al. Non-radioactive detection of mycobacterium tuberculosis LCR products in a microtitre plate format. Molecular and Cellular Probes. (England) 7(3):179-186 (1993).

Wirth et al. Staining methods in gel electrophoresis, including the use of multiple detection methods. J Chromatogr. 698:123-143 (1995).

Young et al. Quantitative analysis of solution hybridization. Nucleic Acid Hybridisation: A Practical Approach. (IRL Press, 1985) pp. 47-71.

Yu et al. Cyanine dye dUTP analogs for enzymatic labeling of DNA probes. Nucleic Acids Research. 22(15):3226-3232 (1994).

Zehavi et al. Light-Sensitive Glycosides. I. 6-nitroveratryl β-D-glucopyranoside and 2-nitrobenzyl β-D-glucopyranoside. J Organic Chem. 37(14):2281-2285 (1972).

Zehavi et al. Light sensitive glycosides. II. 2-Nitrobenzyl 6-Deoxy-a-L-mannopyranoside and 2-Nitrobenzyl 6-Deoxy-β-L-galactopyranoside. J Organic Chem. 37(14):2285-2285 (1972).

Zhang et al. Amplification of target-specific, ligation-dependent circular probe. Gene 211:277-285 (1990).

Zhang et al. Whole genome amplification from a single cell: Implications for genetic analysis. Proc. Natl. Acad. Sci. USA 89:5847-5851 (Jul. 1992).

Zhu et al., Global Analysis of Protein Activities Using Proteome Chips. Science 293(5537):2101-2105 (2001).

Zhu et al. Purification and characterization of PRD1 DNA polymerase. Biochimica Biophysica Acta. 1219(2):267-276 (1994).

Zijderveld et al., Helix-destabilizing properties of the adenovirus DNA-binding protein. Journal of Virology. 68(2):1158-1164 (1994).

Abravaya, et al., “Detection Of Point Mutations With A Modified Ligase Chain Reaction (Gap-Lcr)”, Nucleic Acids Res. 23(4): 675-682 (1995).

Aliotta, et al., “Thermostable Bst Dna Polymerase Lacks A 3′-5′ Proofreading Exonuclease Activity,” Genet, Anal 12:185-195 (1996).

Alves & Carr, “Dot Blot Detection Of Point Mutatiosn With Adjacently Hybridising Synthetic Oligonuccleotide Probes”, Nucleic Acids Res, 16(17): 8723 (1988.

Arnold, Et El., “Assay Formats Involving Acridinium-Ester-Labeled-Dna Probes”, Clin. Chem. 35(8): 1588-1594 (1989).

Baner et al. Signal Amplification Of Padlock Probes By Rolling Circle Replication, Nucleic Acids Research, Oxford University Press, Surrey, 26(22):5073-5078 (1998), Xp002112357.

Baner et al. Signal Amplification of Padlock Probes by Rolling Circle Replication, Nucleic Acids Research, Oxford University Press, Surrey, 26(22):5073-5078 (1998), XP002112357.

Barany, “Genetic Disease Detection And Dna Amplification Using Cloned Thermostable ligase”, Proc. Natl Acad Sci. Usa 88:189-193 (1991).

Bertina, et al., “Mutation In Blood Coagulation Factor V Associated With Resistance ˜O Activated Protein C”, Nature 369:64-67 (1994).

Birkenmeyer & Mushahwar, “Dna Probe Amplification Methods”, Journal Of Virological Methods 35:117-126 1991).

Blanco & Salas, “Characterization And Purification Of A Phage Ø29-Encoded Dna Polymerase Required For Initiation Of Replication”, Proc, Nat/ . Acad Scl Usa 81:5325-5329 (1984).

Blanco, Et Ai., “Highly Efficient Dna Synthesis By The Phage E29 Dna Polymerase”, Journal Of Biological Chemistry 264(15): 8935-8940 (1989).

Blanco, et al., “Terminal Protein-Primed Dna Amplification”, Proc. Natl. Acad Sci Usa 91:12198-12202 (1994).

Boehmer & Lehman, “Herpes Simplex Virus Type 1 Icp8: Helix-Destabilizing Properties”, Journal Of Virology 67(2): 711-715 (1993).

Broude, Et El., “Enhanced Dna Sequencing By Hybridization”, Proc, Natl. Acad Sci. Usa 91: 3072-3076′(1 ′˜94).

Burgess & Jacutin, “A New Photolabile Protecting Group For Nucleotides” 'Am. Chem Soc. Abstracts, vol. 221 Abstract 281 (1996).

Butler & Chamberlin, “Bacteriophage Spb-Specific Rna Polymerase”, Journal Of Biological Chemistry 257: 5772-5778 (1982).

Chatterjee, Et El., “Cloning And Overexpression Of The Gone Encoding Bacteriophage T5 Dna 'Polymerase”, Gene 97; 13-19 (1991).

Chetverina, et al., “Cloning Of Rna Molecules In Vitro,” Nucleic Acids Research 21:2349-2353 (1993).

Daubendiek, et al., “Generation Of Catalytic Rnas By Rolling Transcription Of Synthetic Dna Nanocircles,” Nature Biotechnology 15:273-277 (19971.

Daubendiek, Et El., “Rolling-Circle Rna Synthesis; Circular Oligonucleotides As Efficient Substrates For 17 Rna Polymerase.” J, Am, Chem Soc. 117:7818-7819 (1995).

Davanloo, et al., “Cloning And Expression Of The Gone For Bacteriophage T7 Rna Polymerase”, Prec. Nail. Acad, Sci. Usa 81:2035-2039 (1984).

Dynal, Technical Handbook, “Biomagnetic Techniques In Molecular Biology” (Dynal A.S., 1995).

Ernst, Et El.,“Cyanine Dye Labeling Reagents For Sulfhydryl Groups” Cytometry 10:3-10 (1989).

Fire & Xu, “Rolling Replication Of Short Dna Circle”, 'Proc. Natl Acad Scl Usa 92:4641-4645 (1995).

Gasparro, et al,, “Site-Specific Targeting Of Psoralen Photoadducts With A Triple Helix-Forming Oligonucleotide: Characterization Of Psoralen Monoadduct And Crosslink Formation” Nucleic Acids Research 22(14): 2845-2852 (1994).

Gerdes, Et El., “Dynamic Changes In The Higher-Level Chromatin Organization Of Specific Sequences Revealed By In Situ Hybridization In Nuclear Halos,” J. Cell Biol. 126:289-304 (1994).

Gunji, et al. “Correlation Between The Serum Level Of Hepatitis C Virus Rna And Disease Activities In Acute And Chronic Hepatitis C”, Int J. Cancer 52(5): 726-730 (1992).

Guo, et al., “Enhanced Discrimination Of Single Nucleotide Polymorphisms By Artificial Mismatch Hybridization,” Nature Biotechnolcgy 15:331-335 (1997).

Guo, Et El., “Direct Fluorescence Analysis Of Genetic Polymorphisms By Hybridization With Oligonucleotide Arrays On Glass Supports”, Nucleic Acids Res. 22(24): 5456-5465 (1994).

Gupta, Et El., “Ninth International Conference On Aids/Fourth Std World Congress”, Jun. 6-11, 1993, Berlin, Germany.

Gusev et al. Rolling Circle Amplfiication: A New Approach to Increase Sensitivity for Immunohistochemistry and Flow Cytometry, American Journal of Pathology, 159(1): 63-69 (Jul. 2001).

Gusev et al. Rolling Circle Amplfiication: A New Approach To Increase Sensitivity For Immunohistochemistry And Flow Cytometry, American Journal Of Pathology, 159(1): 63-69 (Jul. 2001).

Hacia, et al., “Detection Of Heterozygous Mutations In Brca1 Using High Density Oligonucleotide Arrays And Two-Color Fluorescence Analysis,” Nature Genetics 14:441-447.

Hagiwarai et al., “Quantitation Of Hepatitis C Virus Rna In Serum Of Asymptornatic Blood Donors And Patients With Type C Chronic Liver Disease”, Hepatology 17(4): 545-550 (1993).

Hanvey. et al., “Antisense And Antigone Properties Of Peptide Nucleic Acids”, Science 258:1481-1485 (1 992).

Hata, et al., “Structure Of The Human Ornithine Transcarbamylase Gone”, J,' Biochem. 103:302-308 (1988).

Hendrickson, et al., “High Sensitivity Multianalyte Immunoassay Using Covalent Dna-Labeled Antibodies And Polymerase Chain Reaction”, Nucleic Acids Res. 23(3): 522-529 (1995).

Holloway, et al., “An Exonuclease-Amplification Coupled Capture Technique Improves Detection Of Pcr Product”, Nucleic Acids Research 21 : 3905-3906 (1993).

Hoy & Schimke, “Bromodeoyuridine/Dna Analysis Of Replication In Cho Cells After Exposure To Uv Light”, Mutation :Research 290:217-230 (1993).

Hsuih, et al., “Quantitative Detection Of Hcv Rna Using Novel Ligation-Dependent Polymerase Chain Reaction”, American Association For The Study Of Liver Diseases; (Chicago, Il, Nov. 3-7, 1995) [Poster Abstract].

Itakura, Et El., “Synthesis And Use Of Synthetic Oligonucteotides”,' Annual Review Of Biochemistry 53:323-356 (1984).

Jacobsen, Et El., “The N-Terminal Amino-Acid Sequences O'˜ Dna Polymerase T From Escherichia coil And Of The Large And The Small Fragments Obtained By A Limited Proteolysis”, Eur. J, Biochem. 45:623-627(1974).

Johnstone & Thorpe, Immunochemistry In Practice (Blackwell Scientific Publications, Oxford, England, 1987) pp. 209-216 And 241-242.

Jung, Et El., “Bacteriophage Prdi Dna Polymerase: Evolution Of Dna Polymerases”, Proc. Natl. Acad. Sci. Usa 84:8287 (1987).

Kaboord & Benkovic, “Accessory Proteins Function As Matchmakers In The Assembly Of The T4 Dna Polymerase Holoenzyme”, Current Biology 5:149-157 (1995).

Kalin, Et El., “Evaluation Of The Ligase Chain Reaction (Lcr) For The Detection Of Point Mutations”, Mutation Research 283(2): 119-1 23 (1992).

Kaplan, Et El., “Rapid Photolytic Release Of Adenosine 5′-Triphosphate From A Protected Analogue: Utilization By The Na:K Pump Of Human Red Blood Cell Ghosts” Biochem. 17:1929-1935 {1978).

Keel, “Circular Olig0nucleotides', New Concepts In O(Igonucleotide Design,” Annual Rev. Blomol. Struct. 25:1-28 (1996).

Kellogg, Et El., “Taqstart Antibodyt˜: “Hot Start” Pcr Facilitated By A Neutralizing Monoclonal Antibody Directed Against Taq Dna Polymerase”, Blotechnlques 16(6): 1134-1137 (1994).

Kerkhof, “A Comparison Of Substrates For Quantifying The Signal From A Nonradiolabeled Dna Probe”, Analytical Biochemistry 205:359-364 (1992).

Khrapko, et al., “Hybridization Of Dna With Oligonucieotides Immobilized Ia Gel: A Convenient Method For Detecting Single Base Substitutions”, Molecular Biology (Mosk) (Ussr) 25:718-730 (1991 ).

King, Etal., “Bridging The Gap” Journal Of Biological Chemistry 269(18): 13061-13064 (1994.

Kong, et al., “Characterization Of A Dna Polymerase From The Hyperthermophile Archaea Thermococcus Etora/Is”,Journal Of Bjb/Ogical Chemistry 268:1965-1975 (1993).

Kunk.El, Et El., “Rapid And Efficient Site-Specific Mutagenesis Without Phengtypic Selection” Methods In Enzymology 154:367-382 (1987).

Lamture, Et El., “Direct Detection Of Nucleic Acid Hybridization On The Surface Of A Charge Coupled Device” Nucleic Acids Research 22(11): 2121-2125 (1994).

Landegren, “Molecular Mechanics Of Nucleic Acid Sequence Amplification,” Trends Genetics 9:199-202 (1993).

Landegren, et al., “A Ligase-Mediated Gene Detection Technique”, Science 241:1077-1080 (1988).

Langer, Et El., “Enzymatic Synthesis Of Biotin-Labeled Polynucleotides: Novel Nucleic Acid Affinity Probes”, Proc.. Natl. 4cad. Sci. USA 78(11): 6633-6637 (1981).

Lawyer, Etal., “High-Level Expression, Purification, And Enzymatic Characterization Of Full-Length Thermus Aquaticus Dna Polymerase And A Truncated Form Deficient In 5′ To 3′ Exonuclease Activity”, Pcr Methods Applications 2(4): 275-287 (1993).

Lefrere, Etal., “Towards A New Predictor Of Aids Progression Through The Quantitation Of Htv-1 Dna Copies By Pcr In Hiv-Infected Individuals”, Bn'tish Journal Of Haematology 82(2): 467-471 (1992).

Lesnick & Freier, “Relative Thermodynamic Stability Of Dna, Rna, And Dna:Rna Hybrid Duplexes: Relationship With Base Composition And Structure”, Biochemistry 34: !O807-! 08! 5 (1995}.

Liu, et al., “Rolling Circle Dna Synthesis: Small Circular Oligonucleotides As Efficient Templates For Dna Polymerases,” J, Am. Chem. Soc. 118:1587-1594 (1996).

Lizardi et al. Mutation Detection and Single-Molecule Counting Using Isothermal Rolling-Circle Amplification, Nature Genetics, 19:225-232 (1998).

Lizardi et al. Mutation Detection And Single-Molecule Counting Using Isothermal Rolling-Circle Amplification, Nature Genetics, 19:225-232 (1998).

Loakes et al. “5-Nitroindole as a universal base analogue” Nucleic Acids Res. 1994, 22(20):45039-4043.

Lockhart, Et El., “Expression Monitoring By Hybridization To High-Density Oligonucleotide Arrays,” Nature Biotechnology 14:1 675-1680 (1996).

Lu, et al., “High Concentration Of Peripheral Blood Mononuclear Cells Harboring Infectious Virus Correlates With Rapid Progression Of Human Immunodeficiency Virus Type 1 -Related Diseases”, Jid 168(5): 11 65-8116 (1993).

Lukyanov, et al., “Molecule By Molecule Pcr Amplification Of Complex Dna Mixtures For Direct Sequencing: An Approach To In Vitro Cloning,” Nucleic Acids Research 20:1691-1696 (1996).

Luo, Et El., “Improving The Fidelity Of Thermus Thermophilus Dna Ligase,” Nucl Acids Res, 24′.3071-3078 (1 996}.

Marshall, et al., Detection Of Hcv Rna By The Asymmetric Gap Ligase Chain Reaction!, Pcr Methods And Applications 4:80-84 (1994).

Maskos, et al., “Oligonucleotide Hybridizations On Glass Supports; A Novel Linker For Oligonucleotides Synthesized In Situ,” Nucleic Acids Research 20:1 679-1684 (1992).

Matsumoto, Et El., Primary Structure Of Bacteriophage M2 Dna Polymerase: Conserved Segments Within Protein-Riming Dna Polymerases And Dna Polymerase I Of Escherichia coli, Gene 84(2): 247-255 (1989).

Mccray, Et At., “A New Approach To Time-Resolved Studies Of Atp-Requiring Biological' Systems: Laser Flash Photolysis Of Caged Atp” Proc. Natl. Acad. Sci. Usa 77:7237-7241 (1980).

Mcgraw, et al. “Sequence-Dependant Oligonucleotide-Target Duplex Stabilities: Rules From Empirical Studies With A Set Of Twenty-Mers” Biotechniques 8:674-(˜78 (1990).

Melton, Et El., “Efficient In Vitro Synthesis Of Biologically Active Rna And Rna Hybridization Probes From Plasmids Containing A Bacteriophage Sp6 Promoter”, Nucleic Acids Research 12(1 8): 7035-7056 (1984).

Metzker, Et El., “Termination Of Dna Synthesis By Novel 3′-Modified-Deoxyribonucleoside 5′˜Triphosphates” Nucleicacids Research 22:4259-4267 (1994).

Mujumdar, Et El., “Cyanine Dye Labeling Reagents Containing Isothiocyanate Groups” Cytometry 1 0;11-1 9 (1989).

Mullenix et al. Allergen-specific IgE Detection on Microarrays Using Rolling Circle Amplification: Correlation with in Vitro Assays for Serum IgE, Clinical Chemistry, 47(10):1926-1929 (2001).

Narang, Et El., “Chemical Synthesis Of Deoxyoligonucleotides By The Modified Triester Method”, Methods Enzymology 65; 610-620 (1980).

Newton, et al., “Analysis Of Any Point Mutation In Dna'. The Amplification Refractory Mutation Refractory Mutation System (Arms),” Nucl. Acids Res. 17:2503-2516 (1989).

Nielsen, et al,, “Peptide Nucleic Acid {Pna). A Dna Mimic With A Peptide Backbone”, Bioconjugate Chemistry, 5: 3-7 (1994).

Nielsen, Et El., “Peptide Nucleic Acids (Pnas): Potential Anti-Sense And Anti-Gone Agents”, Anti-Cancer Drug Design, 8:53-63 (1993).

Nikiforov, At El., “Genetic Bit Analysis: A Solid Phase Method For Typing Single Nucleotide Poivmorphisms”, Nucleic Acids Research 22(20): 4-167-4175 (1994).

Nikiforov, et al., “The Use Of Phosphorothioate Primers And Exonuclease Hydrolysis For The Preparation Of Single-Stranded Pcr Products And Their Detection By Solid-Phase Hybridization”, Pcr Methods And Applications 3:285-291 (1994).

Nilsson, et al., Padlock Probes: Circularizing Oligonucteotides For Localized Dna Detection . . . , Science 265: 2085-2088 (1994).

Nilsson, et al., “U. Padlock Probes Reveal Single-Nucleotide Differences, Parent Of Origin And In Site Distribution Of Centromeric Sequences In Human Chromosomes 13 And 21,” Nature Genet. 16:252-255 (1997).

Nuovo, et al. In Situ Amplification Using Universal Energy Transfer-labeled Primers, The Journal of Histochemistry & Cytochemistry, The Histochemical Society, Inc.; New York, New York 43(3):273-279 (1999), XP008002684.

Orum, Et El., “Single Base Pair Mutation Analysis By Pna Directed Pcr Clamping”, Nucle/C Acids Research 21(23): 5332-5336 (1993).

Panasnko, Et El., A Simple, Three-Step Procedure For The Large Scale Purification Of Dna Ligase From A Hybrid Lysogen Construction In Vitro, Journal Biological Cher˜Istry 253; 4-590-4592 (1978).

Pease, Et El., “Eight-Generated Oligonucleotide Arrays For Rapid Dna Sequence Analysis”, Proc, Natl. Acad, Scl Usa 91(11): 5022-5026 (1994).

Piatak, Et El., “High Levels Of Hiv-1 in Plasma During All Stages Of Infection Determined By Competitive Pcr”, Science 259(5102): 1749-1754 (1993).

Pillai, Et El., “Photoremovable Protecting Groups In Organic Synthesis” Synthesis 1-26 (1980).

Pokrovskaya & Gurevich, “In Vitro Transcription: Preparative Rna Yields In Analytical Scale Reactions”, Analytical Biochemistry 220:420-423 (1994).

Prakash, Et El., “Structural Effects In The Recognition Of Dna By Circular Oligonucleotides,” J. Amer. Chem. Soc. 114;3523-3527 (1992).

Richards, Et El., “Conditional Mutator Phenotypes In Hms2h2-Deficient Tumor Cell Lines,” Science 277:1523-1526 (1997).

Ried, Et El, “Simultaneous Visualization Of Seven Different Dna Probes By In Situ Hybridization Using Combinatorial Fluorescence And Digital Imaging Microscopy”, Proc. Natl. Acad. Sci. Usa 89(4)′. 1388-1392 (1982).

Rigler & Romano, “Differences In The Mechanism Of Stimulation Of T7 Dna Polymerase By Two Binding Modes Of Escherichia coli/Single-Stranded Dna-Binding Protein”, Journal Of Biological Chemistry, 270(15): 8910-8919 (1995).

Rychlik, Et El, “Optimization Of The Annealing Temperature For Dna Amplification In Vitro”, Nucleic Acids Research 18(21): 6409-6412 (1990).

Rys & PersIng, “Preventing False Positives: Quantitative Evaluation ˜F Three Protocols For Inactivation Of Polymerase Chain Reaction Amplification Products”, Journal Of Clinical Microbiology 31 {9): 2356-2360 (1993).

Saksela, et al., “Human Immunodeficiency Virus Type 1 Mrna Expression In Peripheral Blood Cells Predicts Disease Progression Independently Of The Numbers Of Cd4+ Lymphocytes”, Proc. Natl. Acad. Sci. Usa 91(3): 1104-11 08 (1994).

Sambrook, et al., “Molecular Cloning: A Laboratory Manual, Second Edition” (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N,Y., 1989 (Chapters 5, 6)).

Saris, et al., “Blotting Of Rna Into Rna Exchange Paper Allowing Subsequence Characterization By In Situ Translation In Addition To Blot Hybridization,” Nucleic Acids Res. 10:4831-4843 (1982).

Schena, Et Ai., “Quantitative Monitoring Of Gone Expression Patterns With A Complementary Dna Microarray” Science 270:467-470 (1995).

Schena, Etal., “Parallel Human Genome Analysis: Microarray-Based Expression Monitoring Of 1000 Genes,” Proc.Natl, Acad, Sci. Usa 91:10614-10619 (1994).

Schenborn & Meirendorf, “A Novel Transcription Property Of Sp6 And 17 Rna Polymerases: Dependence On Template Structure”, Nucleic Acids Research 13(17): 6223-6236 (1985).

Schwarz, “Improved Yields Of Long Pcr Products Using Gone 32 Protein,” Nucl Acids Res. 18:1079 (1990).

Schweitzer et al. Immunoassays with Rolling Circle DNA Amplification: A Versatile Platform for Ultrasensitive Antigen Detection, PNAS, 97(18):10113-10119 (Aug. 29, 2000).

Schweitzer et al. Multiplexed Protein Profiling on Microarrays by Rolling-Circle Amplification, Nature Biotechnology, 20:359-365 (Apr. 2002).

Schweitzer et al. Multiplexed Protein Profiling On Microarrays By Rolling-Circle Amplification, Nature Biotechnology, 20:359-365 (Apr. 2002).

Siegel, et al., “A Novel Dna Helicase From Calf Thymus”, Journal Of Biological Chemistry 267(19): 13629-13635 [1992).

Skaliter & Lehman, “Rolling Circle Dna Replication In Vitro By A Complex Of Herpes Simplex Virus Type 1-Encoded Enzymes”, Proc, Natl. Acad. Scl Usa 91(22): 10665-10669 (1994).

Tyagi et al. Molecular Beacons: Probes that Fluoresce upon Hybridization, Nature Biotechnology, 14:303-308 (Mar. 1996), XP000196024.

U.S. Appl. No. 09/803,713, filed Mar. 9, 2001, Alsmadi et al., Issue Notification, May 14, 2003.

U.S. Appl. No. 09/803,713, filed Mar. 9, 2001, Alsmadi et al., Notice of Allowance, Feb. 4, 2003.

U.S. Appl. No. 09/803,713, filed Mar. 9, 2001, Alsmadi et al., Supplemental Response, Jan. 23, 2003.

U.S. Appl. No. 09/803,713, filed Mar. 9, 2001, Alsmadi et al., Response after Non-Final Action, Nov. 5, 2002.

U.S. Appl. No. 09/803,713, filed Mar. 9, 2001, Alsmadi et al., Non-Final Rejection, Jun. 5, 2002.

U.S. Appl. No. 09/803,713, filed Mar. 9, 2001, Alsmadi et al., Response to Election / Restriction Filed, Mar. 29, 2002.

U.S. Appl. No. 09/803,713, filed Mar. 9, 2001, Alsmadi et al., Restriction Requirement, Feb. 21, 2002.

U.S. Appl. No. 10/325,490, filed Dec. 19, 2002, Alsmadi et al., Abandonment for Failure to Respond to Office Action, Mar. 8, 2007.

U.S. Appl. No. 10/325,490, filed Dec. 19, 2002, Alsmadi et al., Non-Final Rejection, Aug. 9, 2006.

U.S. Appl. No. 10/325,490, filed Dec. 19, 2002, Alsmadi et al., Response after Non-Final Action, May 25, 2006.

U.S. Appl. No. 10/325,490, filed Dec. 19, 2002, Alsmadi et al., Non-Final Rejection, Jan. 24, 2006.

U.S. Appl. No. 10/325,490, filed Dec. 19, 2002, Alsmadi et al., Response to Election / Restriction Filed, Oct. 21, 2005.

U.S. Appl. No. 10/325,490, filed Dec. 19, 2002, Alsmadi et al., Restriction Requirement, Sep. 16, 2005.

U.S. Appl. No. 10/404,944, filed Mar. 31, 2003, Alsmadi et al., Abandonment for Failure to Respond to Office Action, Nov. 27, 2006.

U.S. Appl. No. 10/404,944, filed Mar. 31, 2003, Alsmadi et al., Non-Final Rejection, May 9, 2006.

U.S. Appl. No. 10/404,944, filed Mar. 31, 2003, Alsmadi et al., Response after Non-Final Action, Mar. 6, 2006.

U.S. Appl. No. 10/404,944, filed Mar. 31, 2003, Alsmadi et al., Non-Final Rejection, Dec. 5, 2005.

U.S. Appl. No. 09/547,757, filed Apr. 12, 2000, Faruqi, Issue Notification, Mar. 21, 2002.

U.S. Appl. No. 09/547,757, filed Apr. 12, 2000, Faruqi, Notice of Allowance, Aug, 31, 2001.

U.S. Appl. No. 09/597,836, filed Jun. 20, 2000, Kingsmore et al., Issue Notification, Feb. 20, 2003.

U.S. Appl. No. 09/597,836, filed Jun. 20, 2000, Kingsmore et al., Notice of Allowance, Nov. 17, 2002.

U.S. Appl. No. 09/597,836, filed Jun. 20, 2000, Kingsmore et al., RCE with Response to Office Action, Sep. 18, 2002.

U.S. Appl. No. 09/597,836, filed Jun. 20, 2000, Kingsmore et al., Final Rejection, Mar. 19, 2002.

U.S. Appl. No. 09/597,836, filed Jun. 20, 2000, Kingsmore et al., Response after Non-Final Action, Feb. 6, 2002.

U.S. Appl. No. 09/597,836, filed Jun. 20, 2000, Kingsmore et al., Non-Final Rejection, Nov. 5, 2001.

U.S. Appl. No. 09/597,836, filed Jun. 20, 2000, Kingsmore et al., Response after Non-Final Action, Sep. 20, 2001.

U.S. Appl. No. 09/597,836, filed Jun. 20, 2000, Kingsmore et al., Non-Final Rejection, Mar. 20, 2001.

U.S. Appl. No. 09/597,836, filed Jun. 20, 2000, Kingsmore et al., Preliminary Amendment, Oct. 26, 2000.

U.S. Appl. No. 10/341,287, filed Jan. 13, 2003, Kingsmore et al., Post Issue Communication—Certificate of Correction, Sep. 7, 2005.

U.S. Appl. No. 10/341,287, filed Jan. 13, 2003, Kingsmore et al., Request for Certificate of Correction, Aug. 25, 2005.

U.S. Appl. No. 10/341,287, filed Jan. 13, 2003, Kingsmore et al., Issue Notification, Jul. 6, 2005.

U.S. Appl. No. 10/341,287, filed Jan. 13, 2003, Kingsmore et al., Notice of Allowance, Mar. 15, 2005.

U.S. Appl. No. 10/341,287, filed Jan. 13, 2003, Kingsmore et al., Response after Non-Final Action, Jan. 4, 2005.

U.S. Appl. No. 10/341,287, filed Jan. 13, 2003, Kingsmore et al., Terminal Disclaimer Filed, Jan. 4, 2005.

U.S. Appl. No. 10/341,287, filed Jan. 13, 2003, Kingsmore et al., Non-Final Rejection, Oct. 22, 2004.

U.S. Appl. No. 11/187,537, filed Jul. 22, 2005, Kingsmore et al., Requirement for Restriction / Election, Oct. 1, 2008/

U.S. Appl. No. 11/187,537, filed Jul. 22, 2005, Kingsmore et al., Miscellaneous Communication to Applicant Notice of Defective Declaration, Oct. 4, 2007.

U.S. Appl. No. 11/187,537, filed Jul. 22, 2005, Kingsmore et al., Petition Decision—Granted, Mar. 2, 2006.

U.S. Appl. No. 11/187,537, filed Jul. 22, 2005, Kingsmore et al., Petition Entered, Dec. 23, 2005.

U.S. Appl. No. 09/897,259, filed Jul. 2, 2001, Ward et al., Issue Notification, Jan. 15, 2004.

U.S. Appl. No. 09/897,259, filed Jul. 2, 2001, Ward et al., Examiner's Amendment, Dec. 8, 2003.

U.S. Appl. No. 09/897,259, filed Jul. 2, 2001, Ward et al., Notice of Allowance, Jul. 1, 2003.

U.S. Appl. No. 09/897,259, filed Jul. 2, 2001, Ward et al., Response after Non-Final Action, Apr. 18, 2003.

U.S. Appl. No. 09/897,259, filed Jul. 2, 2001, Ward et al., Non-Final Rejection, Jan. 17, 2003.

U.S. Appl. No. 09/897,259, filed Jul. 2, 2001, Ward et al., Response to Election / Restriction Filed, Nov. 4, 2002.

U.S. Appl. No. 09/897,259, filed Jul. 2, 2001, Ward et al., Restriction Requirement, Sep. 30, 2002.

U.S. Appl. No. 09/910,383, filed Jul. 20, 2001, Nallur et al., Abandonment for Failure to Respond to Office Action, Nov. 14, 2007.

U.S. Appl. No. 09/910,383, filed Jul. 20, 2001, Nallur et al., Advisory Action (PTOL-303), May 1, 2007.

U.S. Appl. No. 09/910,383, filed Jul. 20, 2001, Nallur et al., Amendment/Argument after Notice of Appeal, Apr. 18, 2007.

U.S. Appl. No. 09/910,383, filed Jul. 20, 2001, Nallur et al., Notice of Apeal Filed, Apr. 18, 2007.

U.S. Appl. No. 09/910,383, filed Jul. 20, 2001, Nallur et al., Examiner Interview Summary (PTOL-413), Apr. 9, 2007.

U.S. Appl. No. 09/910,383, filed Jul. 20, 2001, Nallur et al., Final Rejection (PTOL-326), Dec. 13, 2006.

U.S. Appl. No. 09/910,383, filed Jul. 20, 2001, Nallur et al., Response after Non-Final Action, Oct. 2, 2006.

U.S. Appl. No. 09/910,383, filed Jul. 20, 2001, Nallur et al., Non-Final Rejection, Jun. 15, 2006.

U.S. Appl. No. 09/910,383, filed Jul. 20, 2001, Nallur et al., Withdrawal of Informal Amendment Notice, Apr. 7, 2006.

U.S. Appl. No. 09/910,383, filed Jul. 20, 2001, Nallur et al., Response after Non-Final Action, Mar. 22, 2006.

U.S. Appl. No. 09/910,383, filed Jul. 20, 2001, Nallur et al., Notice of Informal or Non-Responsive RCE Amendment, Mar. 27, 2006.

U.S. Appl. No. 09/910,383, filed Jul. 20, 2001, Nallur et al., Advisory Action (PTOL-303), Dec. 13, 2005.

U.S. Appl. No. 09/910,383, filed Jul. 20, 2001, Nallur et al., Amendment after Final Rejection, Nov. 23, 2005.

U.S. Appl. No. 09/910,383, filed Jul. 20, 2001, Nallur et al., Examiner Interview Summary Record (PTOL-413), Oct. 12, 2005.

U.S. Appl. No. 09/910,383, filed Jul. 20, 2001, Nallur et al., Advisory Action (PTOL-303), Sep. 14, 2005.

U.S. Appl. No. 09/910,383, filed Jul. 20, 2001, Nallur et al., Amendment after Final Rejection, Aug. 26, 2005.

U.S. Appl. No. 09/910,383, filed Jul. 20, 2001, Nallur et al., Final Rejection (PTOL-326), May 23, 2005.

U.S. Appl. No. 09/910,383, filed Jul. 20, 2001, Nallur et al., Response after Non-Final Action, Mar. 14, 2005.

U.S. Appl. No. 09/910,383, filed Jul. 20, 2001, Nallur et al., Non-Final Rejection, Jan. 27, 2005.

U.S. Appl. No. 09/910,383, filed Jul. 20, 2001, Nallur et al., Response after Non-Final Action, Nov. 22, 2004.

U.S. Appl. No. 09/910,383, filed Jul. 20, 2001, Nallur et al., Non-Final Rejection, Jun. 23, 2004.

U.S. Appl. No. 09/977,868, filed Oct. 15, 2001, Dean et al., Issue Notification, Nov. 30, 2005.

U.S. Appl. No. 09/977,868, filed Oct. 15, 2001, Dean et al., Notice of Allowance, Feb. 22, 2005.

U.S. Appl. No. 09/977,868, filed Oct. 15, 2001, Dean et al., Examiner's Amendment, Feb. 22, 2005.

U.S. Appl. No. 09/977,868, filed Oct. 15, 2001, Dean et al., Response after Non-Final Action, Jan. 4, 2005.

U.S. Appl. No. 09/977,868, filed Oct. 15, 2001, Dean et al., Non-Final Rejection, Sep. 9, 2004.

U.S. Appl. No. 09/977,868, filed Oct. 15, 2001, Dean et al., Preliminary Amendment, Apr. 11, 2002.

U.S. Appl. No. 09/982,212, filed Oct. 18, 2001, Dean et al., Issue Notification, Aug. 21, 2003.

U.S. Appl. No. 09/982,212, filed Oct. 18, 2001, Dean et al., Notice of Allowance, May 20, 2003.

U.S. Appl. No. 09/982,212, filed Oct. 18, 2001, Dean et al., Response after Non-Final Action, May 7, 2003.

U.S. Appl. No. 09/982,212, filed Oct. 18, 2001, Dean et al., Non-Final Rejection, Apr. 18, 2003.

U.S. Appl. No. 09/982,212, filed Oct. 18, 2001, Dean et al., Preliminary Amendment, Jan. 24, 2002.

U.S. Appl. No. 09/982,212, filed Oct. 18, 2001, Dean et al., Preliminary Amendment, Oct. 8, 2001.

U.S. Appl. No. 10/272,465, filed Oct. 15, 2002, Dean et al., Decision on Petition to Revive, May 22, 2006.

U.S. Appl. No. 10/272,465, filed Oct. 15, 2002, Dean et al., Petition to Revive Application, Mar. 16, 2006.

U.S. Appl. No. 10/272,465, filed Oct. 15, 2002, Dean et al., Issue Notification, Jun. 21, 2006.

U.S. Appl. No. 10/272,465, filed Oct. 15, 2002, Dean et al., Notice of Allowance, Dec. 13, 2005.

U.S. Appl. No. 10/272,465, filed Oct. 15, 2002, Dean et al., Examiner's Amendment, Dec. 13, 2005.

U.S. Appl. No. 10/272,465, filed Oct. 15, 2002, Dean et al., Terminal Disclaimer Filed, Sep. 6, 2005.

U.S. Appl. No. 10/272,465, filed Oct. 15, 2002, Dean et al., Response after Non-Final Action, Sep. 6, 2005.

U.S. Appl. No. 10/272,465, filed Oct. 15, 2002, Dean et al., Non-Final Rejection, Aug. 5, 2005.

U.S. Appl. No. 10/429,229, filed May 2, 2003, Bornarth et al., Issue Notification, Oct. 31, 2007.

U.S. Appl. No. 10/429,229, filed May 2, 2003, Bornarth et al., Issue Fee Payment Received, Sep. 17, 2007.

U.S. Appl. No. 10/429,229, filed May 2, 2003, Bornarth et al., Supplemental Notice of Allowance, Jul. 31, 2007.

U.S. Appl. No. 10/429,229, filed May 2, 2003, Bornarth et al., Notice of Allowance, Jun. 18, 2007.

U.S. Appl. No. 10/429,229, filed May 2, 2003, Bornarth et al., Examiner Interview Summary (PTOL-413), Jun. 18, 2007.

U.S. Appl. No. 10/429,229, filed May 2, 2003, Bornarth et al., Examiner's Amendment, Jun. 18, 2007.

U.S. Appl. No. 10/429,229, filed May 2, 2003, Bornarth et al., Amendment after Final Rejection, Jun. 5, 2007.

U.S. Appl. No. 10/429,229, filed May 2, 2003, Bornarth et al., Final Rejection (PTOL-326), Feb. 28, 2007.

U.S. Appl. No. 10/429,229, filed May 2, 2003, Bornarth et al., Response after Non-Final Action & Terminal Disclaimer, Dec. 18, 2006.

U.S. Appl. No. 10/429,229, filed May 2, 2003, Bornarth et al., Non-Final Rejection, Jun. 20, 2006.

U.S. Appl. No. 10/429,229, filed May 2, 2003, Bornarth et al., Response to Election / Restriction Filed, Apr. 21, 2006.

U.S. Appl. No. 10/429,229, filed May 2, 2003, Bornarth et al., Restriction Requirement, Feb. 16, 2006.

U.S. Appl. No. 11/871,707, filed Oct. 12, 2007, Bornarth et al., Non-Final Rejection, Jan. 28, 2009.

U.S. Appl. No. 11/871,707, filed Oct. 12, 2007, Bornarth et al., Notice of Publication, Jun. 5, 2008.

U.S. Appl. No. 11/871,707, filed Oct. 12, 2007, Bornarth et al., Preliminary Amendment, Jan. 31, 2008.

U.S. Appl. No. 08/754,681, filed Nov. 21, 1996, Lizardi et al., Issue Notification, Oct. 20, 2000.

U.S. Appl. No. 08/754,681, filed Nov. 21, 1996, Lizardi et al., Issue Fee Payment Verified, Jun. 23, 2000.

U.S. Appl. No. 08/754,681, filed Nov. 21, 1996, Lizardi et al., Notice of Allowance, Mar. 28, 2000.

U.S. Appl. No. 08/754,681, filed Nov. 21, 1996, Lizardi et al., Notice of Appeal Filed, Feb. 7, 2000.

U.S. Appl. No. 08/754,681, filed Nov. 21, 1996, Lizardi et al., Amendment after Final Rejection & Terminal Disclaimer Filed, Dec. 30, 1999.

U.S. Appl. No. 08/754,681, filed Nov. 21, 1996, Lizardi et al., Final Rejection (PTOL-326), Aug. 4, 1999.

U.S. Appl. No. 08/754,681, filed Nov. 21, 1996, Lizardi et al., Supplemental Response, Apr. 16, 1999.

U.S. Appl. No. 08/754,681, filed Nov. 21, 1996, Lizardi et al., Response after Non-Final Action, Apr. 6, 1999.

U.S. Appl. No. 08/754,681, filed Nov. 21, 1996, Lizardi et al., Non-Final Rejection, Oct. 1, 1998.

U.S. Appl. No. 08/754,681, filed Nov. 21, 1996, Lizardi et al., Response after Non-Final Action, Jul. 9, 1998.

U.S. Appl. No. 08/754,681, filed Nov. 21, 1996, Lizardi et al., Non-Final Rejection, Jan. 6, 1998.

U.S. Appl. No. 08/754,681, filed Nov. 21, 1996, Lizardi et al., Response after Non-Final Action, Oct. 24, 1997.

U.S. Appl. No. 09/602,428, filed Jun. 23, 2000, Lizardi et al., Issue Notification, Nov. 21, 2001.

U.S. Appl. No. 09/602,428, filed Jun. 23, 2000, Lizardi et al., Notice of Allowance, Jun. 28, 2001.

U.S. Appl. No. 09/602,428, filed Jun. 23, 2000, Lizardi et al., Terminal Disclaimer Filed, Apr. 12, 2001.

U.S. Appl. No. 09/602,428, filed Jun. 23, 2000, Lizardi et al., Response after Non-Final Action, Apr. 12, 2001.

U.S. Appl. No. 09/602,428, filed Jun. 23, 2000, Lizardi et al., Non-Final Rejection, Nov. 22, 2000.

U.S. Appl. No. 09/602,428, filed Jun. 23, 2000, Lizardi et al., Preliminary Amendment, Jun. 23, 2000.

U.S. Appl. No. 09/841,513, filed Apr. 24, 2001, Lizardi, Issue Notification, Sep. 25, 2003.

U.S. Appl. No. 09/841,513, filed Apr. 24, 2001, Lizardi, Terminal Disclaimer Filed, May 7, 2003.

U.S. Appl. No. 09/841,513, filed Apr. 24, 2001, Lizardi, Notice of Allowance, Jan. 16, 2003.

U.S. Appl. No. 09/841,513, filed Apr. 24, 2001, Lizardi, Terminal Disclaimer Filed, Oct. 24, 2002.

U.S. Appl. No. 09/841,513, filed Apr. 24, 2001, Lizardi, Response after Non-Final Action, Oct. 24, 2002.

U.S. Appl. No. 09/841,513, filed Apr. 24, 2001, Lizardi, Non-Final Rejection, Apr. 30, 2002.

U.S. Appl. No. 09/841,513, filed Apr. 24, 2001, Lizardi, Preliminary Amendment, Apr. 24, 2001.

U.S. Appl. No. 10/413,041, filed Apr. 10, 2003, Lizardi et al., Abandonment for Failure to Respond to Office Action, Apr. 5, 2006.

U.S. Appl. No. 10/413,041, filed Apr. 10, 2003, Lizardi et al., Restriction Requirement, Sep. 22, 2005.

U.S. Appl. No. 10/072,666, filed Feb 8, 2002, Kumar et al., Notice of Allowance, Jan. 27, 2009.

U.S. Appl. No. 10/072,666, filed Feb 8, 2002, Kumar et al., Request for Continuted Examination, Nov. 24, 2008.

U.S. Appl. No. 10/072,666, filed Feb 8, 2002, Kumar et al., Notice of Allowance, Sep. 26, 2008.

U.S. Appl. No. 10/072,666, filed Feb 8, 2002, Kumar et al., Examiner Amendment Communication, Sep. 22, 2008.

U.S. Appl. No. 10/072,666, filed Feb 8, 2002, Kumar et al., Terminal Disclaimer Filed, Sep. 10, 2008.

U.S. Appl. No. 10/072,666, filed Feb 8, 2002, Kumar et al., Amendment after Final Rejection, Sep. 10, 2008.

U.S. Appl. No. 10/072,666, filed Feb 8, 2002, Kumar et al., Final Rejection, Jul. 15, 2008.

U.S. Appl. No. 10/072,666, filed Feb 8, 2002, Kumar et al., Response to Non-Final Action, Apr. 30, 2008.

U.S. Appl. No. 10/072,666, filed Feb 8, 2002, Kumar et al., Non-Final Rejection, Feb. 1, 2008.

U.S. Appl. No. 10/072,666, filed Feb 8, 2002, Kumar et al., Response after Non-Final Action, Nov. 15, 2007.

U.S. Appl. No. 10/072,666, filed Feb 8, 2002, Kumar et al., Non-Final Rejection, Jul. 9, 2007.

U.S. Appl. No. 10/072,666, filed Feb 8, 2002, Kumar et al., Response after Non-Final Action, Apr. 24, 2007.

U.S. Appl. No. 10/072,666, filed Feb 8, 2002, Kumar et al., Non-Final Rejection, Jan. 24, 2007.

U.S. Appl. No. 10/072,666, filed Feb 8, 2002, Kumar et al., Request for Continued Examination (RCE) & Response t/o Office Action, Nov. 30, 2006.

U.S. Appl. No. 10/072,666, filed Feb 8, 2002, Kumar et al., Advisory Action (PTOL-303), Nov. 8, 2006.

U.S. Appl. No. 10/072,666, filed Feb 8, 2002, Kumar et al., Amendment after Final Rejection, Oct. 20, 2006.

U.S. Appl. No. 10/072,666, filed Feb 8, 2002, Kumar et al., Final Rejection (PTOL-326), Jul. 31, 2006.

U.S. Appl. No. 10/072,666, filed Feb 8, 2002, Kumar et al., Response after Non-Final Action, May 15, 2006.

U.S. Appl. No. 10/072,666, filed Feb 8, 2002, Kumar et al., Non-Final Rejection, Jan. 27, 2006.

U.S. Appl. No. 10/072,666, filed Feb 8, 2002, Kumar et al., Examiner Interview Summary Record (PTOL-413), Aug. 11, 2005.

U.S. Appl. No. 10/072,666, filed Feb 8, 2002, Kumar et al., Request for Continued Examination (RCE) & Response to Office Action, Nov. 11, 2005.

U.S. Appl. No. 10/072,666, filed Feb 8, 2002, Kumar et al., Final Rejection (PTOL-326), Jul. 11, 2005.

U.S. Appl. No. 10/072,666, filed Feb 8, 2002, Kumar et al., Response after Non-Final Action, Apr. 27, 2005.

U.S. Appl. No. 10/072,666, filed Feb 8, 2002, Kumar et al., Notice of Restarted Response Period, Feb. 10, 2005.

U.S. Appl. No. 10/072,666, filed Feb 8, 2002, Kumar et al., Non-Final Rejection, Dec. 2, 2004.

U.S. Appl. No. 10/072,666, filed Feb 8, 2002, Kumar et al., Response after Non-Final Action, Aug. 4, 2004.

U.S. Appl. No. 10/072,666, filed Feb 8, 2002, Kumar et al., Non-Final Rejection, Apr. 19, 2004.

U.S. Appl. No. 10/072,666, filed Feb 8, 2002, Kumar et al., Response after Non-Final Action, Nov. 10, 2003.

U.S. Appl. No. 10/072,666, filed Feb 8, 2002, Kumar et al., Non-Final Rejection, May 8, 2003.

U.S. Appl. No. 09/460,078, filed Dec. 14, 1999, Hafner et al., Issue Notification, Nov. 25, 2004.

U.S. Appl. No. 09/460,078, filed Dec. 14, 1999, Hafner et al., Notice of Allowance, Jul. 14, 2004.

U.S. Appl. No. 09/460,078, filed Dec. 14, 1999, Hafner et al., Amendment after Final Rejection, Jun. 17, 2004.

U.S. Appl. No. 09/460,078, filed Dec. 14, 1999, Hafner et al., Examiner Interview Summary (PTOL-413), May 25, 2004.

U.S. Appl. No. 09/460,078, filed Dec. 14, 1999, Hafner et al., Final Rejection (PTOL-326), Feb. 13, 2004.

U.S. Appl. No. 09/460,078, filed Dec. 14, 1999, Hafner et al., Response after Non-Final Action, Nov. 24, 2003.

U.S. Appl. No. 09/460,078, filed Dec. 14, 1999, Hafner et al., Non-Final Rejection, May 19, 2003.

U.S. Appl. No. 09/460,078, filed Dec. 14, 1999, Hafner et al., Response after Non-Final Action, Jan. 14, 2003.

U.S. Appl. No. 09/460,078, filed Dec. 14, 1999, Hafner et al., Non-Final Rejection, Sep. 4, 2002.

U.S. Appl. No. 09/460,078, filed Dec. 14, 1999, Hafner et al., Request for Continued Examination (RCE), Jun. 17, 2002.

U.S. Appl. No. 09/460,078, filed Dec. 14, 1999, Hafner et al., Notice of Appeal Filed, Jan. 25, 2002.

U.S. Appl. No. 09/460,078, filed Dec. 14, 1999, Hafner et al., Final Rejection (PTOL-326), Jul. 17, 2001.

U.S. Appl. No. 09/460,078, filed Dec. 14, 1999, Hafner et al., Response after Non-Final Action, May 23, 2001.

U.S. Appl. No. 09/460,078, filed Dec. 14, 1999, Hafner et al., Non-Final Rejection, Nov. 20, 2000.

U.S. Appl. No. 09/460,078, filed Dec. 14, 1999, Hafner et al., Response to Election / Restriction Filed, Oct. 3, 2000.

U.S. Appl. No. 09/460,078, filed Dec. 14, 1999, Hafner et al., Notice of Restarted Response Period, Jun. 30, 2000.

U.S. Appl. No. 09/460,078, filed Dec. 14, 1999, Hafner et al., Restriction Requirement, May 23, 2000.

U.S. Appl. No. 10/917,580, filed Aug. 13, 2004, Hafner et al., Issue Notification, Mar. 26, 2008.

U.S. Appl. No. 10/917,580, filed Aug. 13, 2004, Hafner et al., Notice of Allowance, Nov. 30, 2007.

U.S. Appl. No. 10/917,580, filed Aug. 13, 2004, Hafner et al., Examiner's Amendment Communication, Nov. 30, 2007.

U.S. Appl. No. 10/917,580, filed Aug. 13, 2004, Hafner et al., Terminal Disclaimer Filed, Oct. 1, 2007.

U.S. Appl. No. 10/917,580, filed Aug. 13, 2004, Hafner et al., Response after Non-Final Action, Oct. 1, 2007.

U.S. Appl. No. 10/917,580, filed Aug. 13, 2004, Hafner et al., Non-Final Rejection, Jun. 25, 2007.

U.S. Appl. No. 10/917,580, filed Aug. 13, 2004, Hafner et al., Response to Election / Restriction Filed, May 10, 2007.

U.S. Appl. No. 10/917,580, filed Aug. 13, 2004, Hafner et al., Restriction Requirement, Jan. 11, 2007.

U.S. Appl. No. 10/917,580, filed Aug. 13, 2004, Hafner et al., Preliminary Amendment, Nov. 19, 2004.

U.S. Appl. No. 10/325,665, filed Dec. 19, 2002, Alsmadi et al., Abandonment for failure to respond to office action, Nov. 10, 2008.

U.S. Appl. No. 10/325,665, filed Dec. 19, 2002, Alsmadi et al., Non-Final Rejection, Apr. 17, 2008.

U.S. Appl. No. 10/325,665, filed Dec. 19, 2002, Alsmadi et al., Examiner Interview Summary, Apr. 17, 2008.

U.S. Appl. No. 10/325,665, filed Dec. 19, 2002, Alsmadi et al., Non-Final Rejection, Oct. 25, 2007.

U.S. Appl. No. 10/325,665, filed Dec. 19, 2002, Alsmadi et al., Amendment/Argument after Notice of Appeal, Sep. 25, 2007.

U.S. Appl. No. 10/325,665, filed Dec. 19, 2002, Alsmadi et al., Final Rejection (PTOL-326), Mar. 26, 2007.

U.S. Appl. No. 10/325,665, filed Dec. 19, 2002, Alsmadi et al., Response after Non-Final Action, Dec. 22, 2006.

U.S. Appl. No. 10/325,665, filed Dec. 19, 2002, Alsmadi et al., Non-Final Rejection, Aug. 3, 2006.

U.S. Appl. No. 10/325,665, filed Dec. 19, 2002, Alsmadi et al., Response after Non-Final Action & Terminal Disclaimer, Apr. 18, 2006.

U.S. Appl. No. 10/325,665, filed Dec. 19, 2002, Alsmadi et al., Non-Final Rejection, Dec. 30, 2005.

U.S. Appl. No. 10/325,665, filed Dec. 19, 2002, Alsmadi et al., Response to Election / Restriction Filed, Sep. 21, 2005.

U.S. Appl. No. 10/325,665, filed Dec. 19, 2002, Alsmadi et al., Restriction Requirement, Apr. 21, 2005.

U.S. Appl. No. 10/335,573, filed Dec. 31, 2002, Kumar et al., Issue Notification, Nov. 30, 2005.

U.S. Appl. No. 10/335,573, filed Dec. 31, 2002, Kumar et al., Notice of Allowance, Mar. 29, 2005.

U.S. Appl. No. 10/335,573, filed Dec. 31, 2002, Kumar et al., Response after Non-Final Action, Dec. 1, 2004.

U.S. Appl. No. 10/335,573, filed Dec. 31, 2002, Kumar et al., Non-Final Rejection, Jul. 29, 2004.

U.S. Appl. No. 11/201,339, filed Aug. 10, 2005, Kumar et al., Abandonment for Failure to Respond to Office Action, May 12, 2008.

U.S. Appl. No. 11/201,339, filed Aug. 10, 2005, Kumar et al., Restriction Requirement, Sep. 25, 2007.

U.S. Appl. No. 10/327,602, filed Dec. 20, 2002, Lasken, Non-Final Rejection, Jan. 5, 2009.

U.S. Appl. No. 10/327,602, filed Dec. 20, 2002, Lasken, Request for Continued Examination (RCE), Dec. 11, 2008.

U.S. Appl. No. 10/327,602, filed Dec. 20, 2002, Lasken, Advisory Action (PTOL-303), Nov. 24, 2008.

U.S. Appl. No. 10/327,602, filed Dec. 20, 2002, Lasken, Amendment after Final Rejection, Nov. 10, 2008.

U.S. Appl. No. 10/327,602, filed Dec. 20, 2002, Lasken, Final Rejection, Aug. 12, 2008.

U.S. Appl. No. 10/327,602, filed Dec. 20, 2002, Lasken, Response after Final Rejection, May 15, 2008.

U.S. Appl. No. 10/327,602, filed Dec. 20, 2002, Lasken, Non-Final Rejection, Jan. 17, 2008.

U.S. Appl. No. 10/327,602, filed Dec. 20, 2002, Lasken, Request for Continued Examination, Oct. 25, 2007.

U.S. Appl. No. 10/327,602, filed Dec. 20, 2002, Lasken, Examiner Interview Summary, Oct. 16, 2007.

U.S. Appl. No. 10/327,602, filed Dec. 20, 2002, Lasken, Amendment after Final, Oct. 1, 2007.

U.S. Appl. No. 10/327,602, filed Dec. 20, 2002, Lasken, Final Rejection, May 23, 2007.

U.S. Appl. No. 10/327,602, filed Dec. 20, 2002, Lasken, Response after Non-Final Rejection, Mar. 15, 2007.

U.S. Appl. No. 10/327,602, filed Dec. 20, 2002, Lasken, Non-Final Rejection, Nov. 14, 2006.

U.S. Appl. No. 10/327,602, filed Dec. 20, 2002, Lasken, Response after Non-Final Rejection, Aug. 28, 2006.

U.S. Appl. No. 10/327,602, filed Dec. 20, 2002, Lasken, Restriction Requirement, Jun. 26, 2006.

U.S. Appl. No. 10/405,822, filed Mar. 31, 2003, Abarzua et al., Advisory Action (PTOL-303), Feb. 27, 2009.

U.S. Appl. No. 10/405,822, filed Mar. 31, 2003, Abarzua et al., Amendment after Final Rejection, Feb. 11, 2009.

U.S. Appl. No. 10/405,822, filed Mar. 31, 2003, Abarzua et al., Examiner Interview Summary Record (PTOL-413), Dec. 11, 2008.

U.S. Appl. No. 10/405,822, filed Mar. 31, 2003, Abarzua et al., Final Rejection, Sep. 11, 2008.

U.S. Appl. No. 10/405,822, filed Mar. 31, 2003, Abarzua et al., Request for Continued Examination, Dec. 28, 2007.

U.S. Appl. No. 10/405,822, filed Mar. 31, 2003, Abarzua et al., Mail Advisory Action (PTOL-303), Nov. 9, 2007.

U.S. Appl. No. 10/405,822, filed Mar. 31, 2003, Abarzua et al., Amendment/Argument after Notice of Appeal, Oct. 30, 2007.

U.S. Appl. No. 10/405,822, filed Mar. 31, 2003, Abarzua et al., Notice of Appeal Filed, Oct. 30, 2007.

U.S. Appl. No. 10/405,822, filed Mar. 31, 2003, Abarzua et al., Mail Final Rejection (PTOL-326), Apr. 30, 2007.

U.S. Appl. No. 10/405,822, filed Mar. 31, 2003, Abarzua et al., Response after Non-Final Action, Jan. 25, 2007.

U.S. Appl. No. 10/405,822, filed Mar. 31, 2003, Abarzua et al., Mail Non-Final Rejection, Aug. 2, 2006.

U.S. Appl. No. 10/405,822, filed Mar. 31, 2003, Abarzua et al., Response to Ejection / Restriction Filed, Jun. 6, 2006.

U.S. Appl. No. 10/405,822, filed Mar. 31, 2003, Abarzua et al., Mail Restriction Requirement, Dec. 13, 2005.

U.S. Appl. No. 10/454,946, filed Jun. 4, 2003, Feaver et al., Non-Final Rejection, Nov. 24, 2008.

U.S. Appl. No. 10/454,946, filed Jun. 4, 2003, Feaver et al., Request for Continued Examination, Aug. 29, 2008.

U.S. Appl. No. 10/454,946, filed Jun. 4, 2003, Feaver et al., Advisory Action (PTOL-303), Mar. 25, 2008.

U.S. Appl. No. 10/454,946, filed Jun. 4, 2003, Feaver et al., Amendment after Final, Mar. 25, 2008.

U.S. Appl. No. 10/454,946, filed Jun. 4, 2003, Feaver et al., Notice of Appeal Filed, Mar. 17, 2008.

U.S. Appl. No. 10/454,946, filed Jun. 4, 2003, Feaver et al., Amendment after Final, Feb. 8, 2008.

U.S. Appl. No. 10/454,946, filed Jun. 4, 2003, Feaver et al., Examiner Interview Summary Record (PTOL-413), Jan. 29, 2008.

U.S. Appl. No. 10/454,946, filed Jun. 4, 2003, Feaver et al., Final Rejection (PTOL-326), Sep. 18, 2007.

U.S. Appl. No. 10/454,946, filed Jun. 4, 2003, Feaver et al., Response after Non-Final Action, Jul. 5, 2007.

U.S. Appl. No. 10/454,946, filed Jun. 4, 2003, Feaver et al., Non-Final Rejection, Feb. 29, 2007.

U.S. Appl. No. 10/454,946, filed Jun. 4, 2003, Feaver et al., Reponse after Non-Final Action, Nov. 20, 2006.

U.S. Appl. No. 10/454,946, filed Jun. 4, 2003, Feaver et al., Non-Final Rejection, Jul. 26, 2006.

U.S. Appl. No. 10/454,946, filed Jun. 4, 2003, Feaver et al., Response to Election / Restriction Filed, May 4, 2006.

U.S. Appl. No. 10/454,946, filed Jun. 4, 2003, Feaver et al., Restriction Requirement, Feb. 6, 2006.

U.S. Appl. No. 10/456,056, filed Jun. 6, 2003, Kumar et al., Amendment/Req. Reconsideration-After Non-Final Reject, Oct. 23, 2008.

U.S. Appl. No. 10/456,056, filed Jun. 6, 2003, Kumar et al., Non-Final Rejection, Aug. 8, 2008.

U.S. Appl. No. 10/456,056, filed Jun. 6, 2003, Kumar et al., Request for Continued Examination (RCE), Apr. 7, 2008.

U.S. Appl. No. 10/456,056, filed Jun. 6, 2003, Kumar et al., Amendment/Argument after Notice of Appeal, Mar. 7, 2008.

U.S. Appl. No. 10/456,056, filed Jun. 6, 2003, Kumar et al., Notice of Appeal, Sep. 6, 2007.

U.S. Appl. No. 10/456,056, filed Jun. 6, 2003, Kumar et al., Examiner Interview Summary Record (PTOL-413), Apr. 17, 2007.

U.S. Appl. No. 10/456,056, filed Jun. 6, 2003, Kumar et al., Final Rejection, Mar. 6, 2007.

U.S. Appl. No. 10/456,056, filed Jun. 6, 2003, Kumar et al., Amendment/Req. Reconsideration-After Non-Final Rejection, Dec. 11, 2006.

U.S. Appl. No. 10/456,056, filed Jun. 6, 2003, Kumar et al., Non-Final Rejection, Aug. 2, 2006.

U.S. Appl. No. 10/456,056, filed Jun. 6, 2003, Kumar et al., Response to Election / Restriction Filed, May 15, 2006.

U.S. Appl. No. 10/456,056, filed Jun. 6, 2003, Kumar et al., Requirement for Restriction / Election, Feb. 23, 2006.

U.S. Appl. No. 09/920,571, filed Jul. 31, 2001, Lasken et al., Final Rejection, Sep. 12, 2008.

U.S. Appl. No. 09/920,571, filed Jul. 31, 2001, Lasken et al., Response after Non-Final Action, Jul. 2, 2008.

U.S. Appl. No. 09/920,571, filed Jul. 31, 2001, Lasken et al., Non-Final Rejection, Mar. 11, 2008.

U.S. Appl. No. 09/920,571, filed Jul. 31, 2001, Lasken et al., Response after Non-Final Action, Dec. 27, 2007.

U.S. Appl. No. 09/920,571, filed Jul. 31, 2001, Lasken et al., Non-Final Rejection, Jun. 28, 2007.

U.S. Appl. No. 09/920,571, filed Jul. 31, 2001, Lasken et al., Response to Election/Restriction Filed, May 7, 2007.

U.S. Appl. No. 09/920,571, filed Jul. 31, 2001, Lasken et al., Mail Restriction Requirement, Mar. 6, 2007.

U.S. Appl. No. 09/920,571, filed Jul. 31, 2001, Lasken et al., Request for Continued Examination (RCE) & Response to Office Action, Dec. 11, 2006.

U.S. Appl. No. 09/920,571, filed Jul. 31, 2001, Lasken et al., Mail Final Rejection (PTOL-326), Jun. 12, 2006.

U.S. Appl. No. 09/920,571, filed Jul. 31, 2001, Lasken et al., Response after Non-Final Rejection, Mar. 29, 2006.

U.S. Appl. No. 09/920,571, filed Jul. 31, 2001, Lasken et al., Mail Non-Final Rejection, Nov. 1, 2005.

U.S. Appl. No. 09/920,571, filed Jul. 31, 2001, Lasken et al., Request for Continued Examination (RCE) & Response to Office Action, Aug. 19, 2005.

U.S. Appl. No. 09/920,571, filed Jul. 31, 2001, Lasken et al., Mail Advisory Action (PTOL-303), Jun. 20, 2005.

U.S. Appl. No. 09/920,571, filed Jul. 31, 2001, Lasken et al., Amendment/Argument after Notice of Appeal, Jun. 2, 2005.

U.S. Appl. No. 09/920,571, filed Jul. 31, 2001, Lasken et al., Notice of Appeal Filed, Jun. 2, 2005.

U.S. Appl. No. 09/920,571, filed Jul. 31, 2001, Lasken et al., Mail final Rejection (PTOL-326), Feb. 14, 2005.

U.S. Appl. No. 09/920,571, filed Jul. 31, 2001, Lasken et al., Response after Non-Final Action, Nov. 24, 2004.

U.S. Appl. No. 09/920,571, filed Jul. 31, 2001, Lasken et al., Mail Non-Final Rejection, Aug. 25, 2004.

U.S. Appl. No. 09/920,571, filed Jul. 31, 2001, Lasken et al., Request for Continued Examination (RCE), Jul. 12, 2004.

U.S. Appl. No. 09/920,571, filed Jul. 31, 2001, Lasken et al., Mail Advisory Action (PROL-303), Jun. 23, 2004.

U.S. Appl. No. 09/920,571, filed Jul. 31, 2001, Lasken et al., Amendment/Argument after Notice of Appeal, Jun. 1, 2004.

U.S. Appl. No. 09/920,571, filed Jul. 31, 2001, Lasken et al., Notice of Appeal Filed, Jun. 1, 2004.

U.S. Appl. No. 09/920,571, filed Jul. 31, 2001, Lasken et al., Mail Final Rejection (PTOL-326), Feb. 18, 2004.

U.S. Appl. No. 09/920,571, filed Jul. 31, 2001, Lasken et al., Response after Non-Final Action, Oct. 17, 2003.

U.S. Appl. No. 09/920,571, filed Jul. 31, 2001, Lasken et al., Mail Non-Final Rejection, Dec. 20, 2002.

U.S. Appl. No. 09/920,571, filed Jul. 31, 2001, Lasken et al., Supplemental Response, Oct. 3, 2003.

U.S. Appl. No. 09/920,571, filed Jul. 31, 2001, Lasken et al., Supplemental Response, Sep. 20, 2002.

U.S. Appl. No. 09/920,571, filed Jul. 31, 2001, Lasken et al., Mail Notice of Informal or Non-Responsive Amendment, Aug. 27, 2002.

U.S. Appl. No. 09/920,571, filed Jul. 31, 2001, Lasken et al., Mail Non-Final Rejection, Dec. 12, 2001.

U.S. Appl. No. 09/577,444, filed May 24, 2000, Kingsmore et al., Issue Notification, Aug. 30, 2001.

U.S. Appl. No. 09/577,444, filed May 24, 2000, Kingsmore et al., Notice of Allowance, Mar. 29, 2001.

U.S. Appl. No. 09/577,444, filed May 24, 2000, Kingsmore et al., Examiner Interview Summary Record (PTOL-413), Mar. 22, 2001.

U.S. Appl. No. 09/897,665, filed Jul. 2, 2001, Kingsmore et al., Issue Notification, Dec. 11, 2003.

U.S. Appl. No. 09/897,665, filed Jul. 2, 2001, Kingsmore et al., Notice of Allowance, Jul. 30, 2003.

U.S. Appl. No. 09/897,665, filed Jul. 2, 2001, Kingsmore et al., Notice of Appeal Filed, Jun. 2, 2003.

U.S. Appl. No. 09/897,665, filed Jul. 2, 2001, Kingsmore et al., Terminal Disclaimer Filed, Jun. 2, 2003.

U.S. Appl. No. 09/897,665, filed Jul. 2, 2001, Kingsmore et al., Final Rejection (PTOL-326), Feb. 25, 2003.

U.S. Appl. No. 09/897,665, filed Jul. 2, 2001, Kingsmore et al., Response after Non-Final Action, Dec. 10, 2002.

U.S. Appl. No. 09/897,665, filed Jul. 2, 2001, Kingsmore et al., Non-Final Rejection, Jul. 19, 2002.

U.S. Appl. No. 09/910,372, filed Jul. 20, 2001, Bandaru et al., Issue Notification, Oct. 2, 2003.

U.S. Appl. No. 09/910,372, filed Jul. 20, 2001, Bandaru et al., Notice of Allowance, Apr. 8, 2003.

U.S. Appl. No. 09/910,372, filed Jul. 20, 2001, Bandaru et al., Response after Non-Final Action, Mar. 20, 2003.

U.S. Appl. No. 09/910,372, filed Jul. 20, 2001, Bandaru et al., Response after Non-Final Action, Jan. 22, 2003.

U.S. Appl. No. 09/910,372, filed Jul. 20, 2001, Bandaru et al., Non-Final Rejection, Nov. 13, 2002.

U.S. Appl. No. 09/910,372, filed Jul. 20, 2001, Bandaru et al., Response to Election / Restriction Filed, Oct. 4, 2002.

U.S. Appl. No. 09/910,372, filed Jul. 20, 2001, Bandaru et al., Restriction Requirement, Sep. 17, 2002.

U.S. Appl. No. 10/465,759, filed Jun. 19, 2003, Bandaru et al., Issue Notification, Oct. 14, 2004.

U.S. Appl. No. 10/465,759, filed Jun. 19, 2003, Bandaru et al., Notice of Allowance, May 4, 2004.

U.S. Appl. No. 10/465,759, filed Jun. 19, 2003, Bandaru et al., Response after Non-Final Action, Apr. 12, 2004.

U.S. Appl. No. 10/465,759, filed Jun. 19, 2003, Bandaru et al., Non-Final Rejection, Jan. 8, 2004.

U.S. Appl. No. 09/723,685, filed Nov. 28, 2000, Abarzua, Issue Notification, Dec. 5, 2002.

U.S. Appl. No. 09/723,685, filed Nov. 28, 2000, Abarzua, Notice of Allowance, Apr. 17, 2002.

U.S. Appl. No. 09/723,685, filed Nov. 28, 2000, Abarzua, Response after Non-Final Action, Dec. 10, 2001.

U.S. Appl. No. 09/723,685, filed Nov. 28, 2000, Abarzua, Non-Final Rejection, Aug. 28, 2001.

U.S. Appl. No. 09/723,685, filed Nov. 28, 2000, Abarzua, Response after Non-Final Action, Jun. 15, 2001.

U.S. Appl. No. 09/723,685, filed Nov. 28, 2000, Abarzua, Non-Final Rejection, Mar. 13, 2001.

U.S. Appl. No. 10/196,539, filed Jul. 16, 2002, Abarzua, Issue Notification, Apr. 19, 2006.

U.S. Appl. No. 10/196,539, filed Jul. 16, 2002, Abarzua, Notice of Allowance, Nov. 15, 2003.

U.S. Appl. No. 10/196,539, filed Jul. 16, 2002, Abarzua, Terminal Disclaimer Filed, Aug. 12, 2005.

U.S. Appl. No. 10/196,539, filed Jul. 16, 2002, Abarzua, Response after Non-Final Action, Aug. 12, 2005.

U.S. Appl. No. 10/196,539, filed Jul. 16, 2002, Abarzua, Non-Final Rejection, Mar. 10, 2005.

U.S. Appl. No. 11/429,549, filed May 5, 2006, Abarzua, Examiner Interview Summary (PTOL 413), Oct. 15, 2008.

U.S. Appl. No. 11/429,549, filed May 5, 2006, Abarzua, Abandonment, Oct. 15, 2008.

U.S. Appl. No. 11/429,549, filed May 5, 2006, Abarzua, Non-Final Rejection, Mar. 26, 2008.

U.S. Appl. No. 11/429,549, filed May 5, 2006, Abarzua, Notice of Publication, Jan. 18, 2007.

U.S. Appl. No. 11/429,549, filed May 5, 2006, Abarzua, Preliminary Amendment, May 5, 2006.

U.S. Appl. No. 09/827,289, filed Apr. 5, 2001, Abarzua, Issue Notification, Jul. 29, 2004.

U.S. Appl. No. 09/827,289, filed Apr. 5, 2001, Abarzua, Notice of Allowance, Apr. 1, 2004.

U.S. Appl. No. 09/827,289, filed Apr. 5, 2001, Abarzua, Supplemental Response, Feb. 17, 2004.

U.S. Appl. No. 09/827,289, filed Apr. 5, 2001, Abarzua, Notice of Informal or Non-Responsive Amendment. Feb. 2, 2004.

U.S. Appl. No. 09/827,289, filed Apr. 5, 2001, Abarzua, Response after Non-Final Action, Jan. 22, 2004.

U.S. Appl. No. 09/827,289, filed Apr. 5, 2001, Abarzua, Non-Final Rejection, Sep. 29, 2003.

U.S. Appl. No. 09/827,289, filed Apr. 5, 2001, Abarzua, Request for Continued Examination (RCE), Aug. 6, 2003.

U.S. Appl. No. 09/827,289, filed Apr. 5, 2001, Abarzua, Advisory Action (PTOL-303), Jun. 2, 2003.

U.S. Appl. No. 09/827,289, filed Apr. 5, 2001, Abarzua, Amendment after Final Rejection, May 15, 2003.

U.S. Appl. No. 09/827,289, filed Apr. 5, 2001, Abarzua, Final Rejection (PTOL-326), Feb. 10, 2003.

U.S. Appl. No. 09/827,289, filed Apr. 5, 2001, Abarzua, Response after Non-Final Action, Jan. 21, 2003.

U.S. Appl. No. 09/827,289, filed Apr. 5, 2001, Abarzua, Non-Final Rejection, Jul. 29, 2002.

U.S. Appl. No. 09/827,289, filed Apr. 5, 2001, Abarzua, Response to Election / Restriction Filed, Jun. 24, 2002.

U.S. Appl. No. 09/827,289, filed Apr. 5, 2001, Abarzua, Restriction Requirement, Jun. 11, 2002.

U.S. Appl. No. 10/177,629, filed Jun. 19, 2002, Wiltshire, Examiner Interview Summary (PTOL-413), Sep. 20, 2007.

U.S. Appl. No. 10/177,629, filed Jun. 19, 2002, Wiltshire, Abandonment for failure to respond to office action, Sep. 15, 2007.

U.S. Appl. No. 10/177,629, filed Jun. 19, 2002, Wiltshire, Final Rejection (PTOL-326), Aug. 21, 2006.

U.S. Appl. No. 10/177,629, filed Jun. 19, 2002, Wiltshire, Response after Non-Final Action & Terminal Disclaimer, Jun. 12, 2006.

U.S. Appl. No. 10/177,629, filed Jun. 19, 2002, Wiltshire, Non-Final Rejection, Jan. 10, 2006.

U.S. Appl. No. 10/177,629, filed Jun. 19, 2002, Wiltshire, Response to Election / Responsive Amendment, Sep. 30, 2005.

U.S. Appl. No. 10/177,629, filed Jun. 19, 2002, Wiltshire, Notice of Informal or Non-Responsive Amendment, Sep. 30, 2005.

U.S. Appl. No. 10/177,629, filed Jun. 19, 2002, Wiltshire, Response to Election / Restriction Filed, Sep. 19, 2005.

U.S. Appl. No. 10/177,629, filed Jun. 19, 2002, Wiltshire, Restriction Requirement, Mar. 17, 2005.

U.S. Appl. No. 09/931,736, filed Aug. 17, 2001, Shao, Issue Notification, Feb. 9, 2005.

U.S. Appl. No. 09/931,736, filed Aug. 17, 2001, Shao, Notice of Allowance, Nov. 18, 2004.

U.S. Appl. No. 09/931,736, filed Aug. 17, 2001, Shao, Appeal Brief Filed, Aug. 27, 2004.

U.S. Appl. No. 09/931,736, filed Aug. 17, 2001, Shao, Advisory Action (PTOL-303), May 4, 2004.

U.S. Appl. No. 09/931,736, filed Aug. 17, 2001, Shao, Amendment/Argument after Notice of Appeal, Mar. 1, 2004.

U.S. Appl. No. 09/931,736, filed Aug. 17, 2001, Shao, Notice of Appeal filed, Mar. 1, 2004.

U.S. Appl. No. 09/931,736, filed Aug. 17, 2001, Shao, Final Rejection (PTOL-326), Dec. 3, 2003.

U.S. Appl. No. 09/931,736, filed Aug. 17, 2001, Shao, Response after Non-Final Action, Sep. 22, 2003.

U.S. Appl. No. 09/931,736, filed Aug. 17, 2001, Shao, Non-Final Rejection, Jun. 30, 2003.

U.S. Appl. No. 09/931,736, filed Aug. 17, 2001, Shao, Response to Election / Restriction Filed, May 16, 2003.

U.S. Appl. No. 09/931,736, filed Aug. 17, 2001, Shao, Restriction Requirement, Apr. 15, 2003.

U.S. Appl. No. 10/931,015, filed Aug. 31, 2004, Shao, Abandonment for Failure to Respond to Office Action, Aug. 8, 2006.

U.S. Appl. No. 10/931,015, filed Aug. 31, 2004, Shao, Final Rejection (PTOL-326), Jan. 9, 2006.

U.S. Appl. No. 10/931,015, filed Aug. 31, 2004, Shao, Response after Non-Final Action, Aug. 26, 2005.

U.S. Appl. No. 10/931,015, filed Aug. 31, 2004, Shao, Non-Final Rejection, May 24, 2005.

U.S. Appl. No. 10/931,015, filed Aug. 31, 2004, Shao, Response to Election / Restriction Filed, Feb. 28, 2005.

U.S. Appl. No. 10/931,015, filed Aug. 31, 2004, Shao, Restriction Requirement, Jan. 24, 2005.

U.S. Appl. No. 11/870,715, filed Oct. 11, 2007, Korfhage et al., Response after Non-Final Action, Feb. 9, 2009.

U.S. Appl. No. 11/870,715, filed Oct. 11, 2007, Korfhage et al., Non-Final Rejection, Nov. 12, 2008.

U.S. Appl. No. 11/744,553, filed May 4, 2007, Korfhage et al., Amendment/Req. Reconsideration-After Non-Final Reje, Dec. 17, 2008.

U.S. Appl. No. 11/744,553, filed May 4, 2007, Korfhage et al., Examiner Interview Summary Record (PTOL-413), Dec. 15, 2008.

U.S. Appl. No. 11/744,553, filed May 4, 2007, Korfhage et al., Non-Final Rejection, Aug. 19, 2008.

U.S. Appl. No. 11/744,553, filed May 4, 2007, Korfhage et al., Response to Restriction Requirement, Jun. 5, 2008.

U.S. Appl. No. 11/744,553, filed May 4, 2007, Korfhage et al., Requirement for Restriction, May 16, 2008.

U.S. Appl. No. 11/744,553, filed May 4, 2007, Korfhage et al., Notice of Publication, Mar. 6, 2008.

U.S. Appl. No. 11/887,678, Korfhage, No Transaction History Generated.

U.S. Appl. No. 11/991,435, Korfhage, Preliminary Amendment, Mar. 3, 2008.

U.S. Appl. No. 08/563,912, filed Nov. 21, 1995, Lizardi, Issue Notification, Nov. 23, 1998.

U.S. Appl. No. 08/563,912, filed Nov. 21, 1995, Lizardi, Notice of Allowance, Aug. 14, 1998.

U.S. Appl. No. 08/563,912, filed Nov. 21, 1995, Lizardi, Examiner Interview Summary Record (PTOL-413), Aug. 10, 1998.

U.S. Appl. No. 08/563,912, filed Nov. 21, 1995, Lizardi, Amendment/Argument after Notice of Appeal, Aug. 6, 1998.

U.S. Appl. No. 08/563,912, filed Nov. 21, 1995, Lizardi, Notice of Appeal Filed, Jun. 15, 1998.

U.S. Appl. No. 08/563,912, filed Nov. 21, 1995, Lizardi, Final Rejection (PTOL-326), Dec. 9, 1997.

U.S. Appl. No. 08/563,912, filed Nov. 21, 1995, Lizardi, Response after Non-Final Action, Sep. 2, 1997.

U.S. Appl. No. 08/563,912, filed Nov. 21, 1995, Lizardi, Notice of Restarted Response Period, Feb. 28, 1997.

U.S. Appl. No. 08/563,912, filed Nov. 21, 1995, Lizardi, Non-Final Rejection, Feb. 7, 1997.

U.S. Appl. No. 08/563,912, filed Nov. 21, 1995, Lizardi, Response to Election / Restriction FIled, Oct. 31, 1996.

U.S. Appl. No. 08/563,912, filed Nov. 21, 1995, Lizardi, Restriction Requirement, Sep. 24, 1996.

U.S. Appl. No. 09/132,553, filed Aug. 11, 1998, Lizardi, Issue Notification, Mar. 15, 2001.

U.S. Appl. No. 09/132,553, filed Aug. 11, 1998, Lizardi, Notice of Allowance, Nov. 7, 2000.

U.S. Appl. No. 09/132,553, filed Aug. 11, 1998, Lizardi, Preliminary Amengment, Aug. 17, 2000.

U.S. Appl. No. 09/132,553, filed Aug. 11, 1998, Lizardi, Non-Final Rejection, Apr. 11, 2000.

U.S. Appl. No. 09/132,553, filed Aug. 11, 1998, Lizardi, Response after Non-Final Action & Terminal Disclaimer Filed, Jan. 19, 2000.

U.S. Appl. No. 09/132,553, filed Aug. 11, 1998, Lizardi, Non-Final Rejection, Sep. 13, 1999.

U.S. Appl. No. 09/644,723, filed Aug. 23, 2000, Lizardi, Issue Notification, Jan. 18, 2002.

U.S. Appl. No. 09/644,723, filed Aug. 23, 2000, Lizardi, Notice of Allowance, Oct. 1, 2001.

U.S. Appl. No. 09/644,723, filed Aug. 23, 2000, Lizardi, Response after Non-Final Action & Terminal Disclaimer Filed, Jul. 16, 2001.

U.S. Appl. No. 09/644,723, filed Aug. 23, 2000, Lizardi, Non-Final Rejection, Mar. 13, 2001.

U.S. Appl. No. 09/132,552, filed Aug. 11, 1998, Lizardi, Issue Notification, Jan. 19, 2001.

U.S. Appl. No. 09/132,552, filed Aug. 11, 1998, Lizardi, Notice of Allowance, Jul. 12, 2000.

U.S. Appl. No. 09/132,552, filed Aug. 11, 1998, Lizardi, Amendment after Final Rejection, Jun. 19, 2000.

U.S. Appl. No. 09/132,552, filed Aug. 11, 1998, Lizardi, Final Rejection (PTOL-326), Apr. 6, 2000.

U.S. Appl. No. 09/132,552, filed Aug. 11, 1998, Lizardi, Response after Non-Final Action & Terminal Disclaimer Filed, Jan. 19, 2000.

U.S. Appl. No. 09/132,552, filed Aug. 11, 1998, Lizardi, Non-Final Rejection, Sep. 13, 1999.

U.S. Appl. No. 10/038,718, filed Jan. 2, 2002, Lizardi, Issue Notification, Sep. 9, 2004.

U.S. Appl. No. 10/038,718, filed Jan. 2, 2002, Lizardi, Notice of Allowance, Apr. 21, 2004.

U.S. Appl. No. 10/038,718, filed Jan. 2, 2002, Lizardi, Response after Non-Final Action & Terminal Disclaimer Filed, Jan. 20, 2004.

U.S. Appl. No. 10/038,718, filed Jan. 2, 2002, Lizardi, Non-Final Rejection, Oct. 22, 2003.

U.S. Appl. No. 10/038,718, filed Jan. 2, 2002, Lizardi, Response to Election / Restriction Filed, Jul. 16, 2003.

U.S. Appl. No. 10/038,718, filed Jan. 2, 2002, Lizardi, Restriction Requirement, Mar. 13, 2003.

U.S. Appl. No. 08/946,732, filed Oct. 8, 1997, Lizardi, Issue Notification, Sep. 8, 2000.

U.S. Appl. No. 08/946,732, filed Oct. 8, 1997, Lizardi, Notice of Allowance, Jun. 22, 1999.

U.S. Appl. No. 08/946,732, filed Oct. 8, 1997, Lizardi, Examiner Interview Summary Record (PTOL-413), Jun. 9, 1999.

U.S. Appl. No. 08/946,732, filed Oct. 8, 1997, Lizardi, Response after Non-Final Action, Apr. 5, 1999.

U.S. Appl. No. 08/946,732, filed Oct. 8, 1997, Lizardi, Non-Final Rejection, Sep. 28, 1998.

U.S. Appl. No. 09/397,915, filed Sep. 17, 1999, Lizardi, Petition Decision—Accept Late Payment of Maintenance Feed—Granted, Oct. 31, 2005.

U.S. Appl. No. 09/397,915, filed Sep. 17, 1999, Lizardi, Petition to Accept Late Payment of Maintenance Fee Payment Filed, Oct. 13, 2005.

U.S. Appl. No. 09/397,915, filed Sep. 17, 1999, Lizardi, Expire Patent, Sep. 28, 2005.

U.S. Appl. No. 09/397,915, filed Sep. 17, 1999, Lizardi, Issue Notification, Aug. 9, 2001.

U.S. Appl. No. 09/397,915, filed Sep. 17, 1999, Lizardi, Notice of Allowance, Apr. 9, 2001.

U.S. Appl. No. 09/397,915, filed Sep. 17, 1999, Lizardi, Examiner Interview Summary Record (PTOL-413), Apr. 4, 2001.

U.S. Appl. No. 09/397,915, filed Sep. 17, 1999, Lizardi, Terminal Disclaimer Filed, Jan. 29, 2001.

U.S. Appl. No. 09/397,915, filed Sep. 17, 1999, Lizardi, Response after Non-Final Action, Jan. 22, 2001.

U.S. Appl. No. 09/397,915, filed Sep. 17, 1999, Lizardi, Non-Final Rejection, Aug. 14, 2000.

U.S. Appl. No. 09/911,226, filed Jul. 23, 2001, Lizardi, Issue Notification, Oct. 16, 2003.

U.S. Appl. No. 09/911,226, filed Jul. 23, 2001, Lizardi, Notice of Allowance, Jun. 3, 2003.

U.S. Appl. No. 09/911,226, filed Jul. 23, 2001, Lizardi, Response after Non-Final Action & Terminal Disclaimer Filed, Mar. 19, 2003.

U.S. Appl. No. 09/911,226, filed Jul. 23, 2001, Lizardi, Non-Final Rejection, Dec. 18, 2002.

U.S. Appl. No. 10/700,018, filed Nov. 3, 2003, Lizardi, Amendment after Final Rejection, Jan. 27, 2009.

U.S. Appl. No. 10/700,018, filed Nov. 3, 2003, Lizardi, Final Rejection, Sep. 15, 2008.

U.S. Appl. No. 10/700,018, filed Nov. 3, 2003, Lizardi, Amendment after Non-Final Rejection, Jun. 12, 2008.

U.S. Appl. No. 10/700,018, filed Nov. 3, 2003, Lizardi, Non-Final Rejection, Jan. 24, 2008.

U.S. Appl. No. 10/700,018, filed Nov. 3, 2003, Lizardi, Response after Non-Final Action, Oct. 31, 2007.

U.S. Appl. No. 10/700,018, filed Nov. 3, 2003, Lizardi, Non-Final Rejection, Aug. 8, 2007.

U.S. Appl. No. 10/700,018, filed Nov. 3, 2003, Lizardi, Response after Non-Final Action, May 14, 2007.

U.S. Appl. No. 10/700,018, filed Nov. 3, 2003, Lizardi, Non-Final Rejection, Nov. 14, 2006.

U.S. Appl. No. 10/700,018, filed Nov. 3, 2003, Lizardi, Response after Non-Final Action, Aug. 28, 2006.

U.S. Appl. No. 10/700,018, filed Nov. 3, 2003, Lizardi, Request for Extension of Time—Granted, Aug. 28, 2006.

U.S. Appl. No. 10/700,018, filed Nov. 3, 2003, Lizardi, Non-Final Requestion, May 18, 2006.

U.S. Appl. No. 10/700,018, filed Nov. 3, 2003, Lizardi, Preliminary Amendment, Nov. 3, 2003.

U.S. Appl. No. 09/357,487, filed Jul. 20, 1999, Lizardi, Issue Notification, Oct. 25, 2001.

U.S. Appl. No. 09/357,487, filed Jul. 20, 1999, Lizardi, Notice of Allowance, Jun. 5, 2001.

U.S. Appl. No. 09/357,487, filed Jul. 20, 1999, Lizardi, Examiner Interview Summary Record (PTOL-413), May 30, 2001.

U.S. Appl. No. 09/357,487, filed Jul. 20, 1999, Lizardi, Examiner Interview Summary Record (PTOL-413), May 28, 2001.

U.S. Appl. No. 09/357,487, filed Jul. 20, 1999, Lizardi, Amendment after Final Rejection, May 21, 2001.

U.S. Appl. No. 09/357,487, filed Jul. 20, 1999, Lizardi, Final Rejection (PTOL-326), Feb. 13, 2001.

U.S. Appl. No. 09/357,487, filed Jul. 20, 1999, Lizardi, Response after Non-Final Action, Jan. 29, 2001.

U.S. Appl. No. 09/357,487, filed Jul. 20, 1999, Lizardi, Non-Final Rejection, Oct. 25, 2000.

U.S. Appl. No. 09/357,487, filed Jul. 20, 1999, Lizardi, Response after Non-Final Action, Sep. 18, 2000.

U.S. Appl. No. 09/357,487, filed Jul. 20, 1999, Lizardi, Non-Final Rejection, May 12, 2000.

PCT/US02/026001, Jan. 30, 2002, Molecular Staging, Inc., International Preliminary Examination Report, Mar. 29, 2004.

PCT/US02/02601, Jan. 30, 2002, Molecular Staging, Inc., International Search Report, Oct. 3, 2002.

TW, 91102150, Feb. 7, 2002, Molecular Staging, Inc.

EP, 01928481.9, Apr. 12, 2001, Molecular Staging, Inc., Communiation under Rule 51(4) EPC, Sep. 11, 2007.

EP, 01928481.9, Apr. 12, 2001, Molecular Staging, Inc., Response to Examination Report, Nov. 27, 2006.

EP, 01928481.9, Apr. 12, 2001, Molecular Staging, Inc., Consultation by Telephone, Nov. 10, 2006.

EP, 01928481.9, Apr. 12, 2001, Molecular Staging, Inc., Response to Examination Report, Mar. 6, 2006.

EP, 01928481.9, Apr. 12, 2001, Molecular Staging, Inc., Examination Report, May 25, 2005.

PCT/US01/11947, Apr. 12, 2001, Molecular Staging, Inc., International Preliminary Examination Report, Apr. 30, 2003.

PCT/US01/11947, Apr. 12, 2001, Molecular Staging, Inc., International Search Report, Mar. 20, 2003.

AU, 2001255331, Apr. 12, 2001, Molecular Staging, Inc.

CA, 2405456, Apr. 12, 2001, Molecular Staging, Inc., Notice of Abandonment, Apr. 12, 2007.

CA, 2405456, Apr. 12, 2001, Molecular Staging, Inc., Notice of Reinstatement, 0/10/2005.

CA, 2405456, Apr. 12, 2001, Molecular Staging, Inc., Notice of Abandonment, Apr. 13, 2004.

CA, 2405456, Apr. 12, 2001, Molecular Staging, Inc., Notice of National Entry, Oct. 2, 2002.

CA, 2405456, Apr. 12, 2001, Molecular Staging, Inc., Notice of Abandonment.

JP, 2001-577404, Apr. 12, 2001, Molecular Staging, Inc.

AU, 2001269944, Jun. 20, 2001, Molecular Staging, Inc., Abandoned Application, Feb. 28, 2007.

AU, 2001269944, Jun. 20, 2001, Molecular Staging, Inc., Examination Report, May 29, 2006.

AU, 2001269944, Jun. 20, 2001, Molecular Staging, Inc., Response to Examination Report, May 16, 2006.

AU, 2001269944, Jun. 20, 2001, Molecular Staging, Inc., Molecular Staging, Inc., Examination Report, May 19, 2005.

CA, 2411838, Jun. 20, 2001, Molecular Staging, Inc., Notice of Abandonment, Jun. 20, 2007.

CA, 2411838, Jun. 20, 2001, Molecular Staging, Inc., Notice of National Entry, Dec. 12, 2002.

CN, 01811542.X, Jun. 20, 2001, Molecular Staging, Inc., Response to Examination Report, Nov. 23, 2005.

CN, 01811542.X, Jun. 20, 2001, Molecular Staging, Inc., Instructions for Responding to Aug. 7, 2005 Examination Report with List of Claims, Nov. 21, 2005.

CN, 01811542.X, Jun. 20, 2001, Molecular Staging, Inc., Examination Report, Aug. 7, 2005.

EP, 1948505.1, Jun. 20, 2001, Molecular Staging, Inc., Notification of European Publication, Feb. 19, 2003.

JP, 2002-503102, Jun. 20, 2001, Molecular Staging, Inc., Request for Examination, Jan. 11, 2007.

PCT/US01/19657, Jun. 20, 2001, Molecular Staging, Inc., International Preliminary Examination Report, Feb. 5, 2003.

PCT/US01/19657, Jun. 20, 2001, Molecular Staging, Inc., International Search Report, Dec. 27, 2001.

SG, 200207285-8, Jun. 20, 2001, Molecular Staging, Inc., Issue Notification, Dec. 16, 2002.

TW, 90114960, Jun. 28, 2001, Molecular Staging, Inc., Office Action, Oct. 3, 2005.

TW, 90114960, Jun. 28, 2001, Molecular Staging, Inc., Response to Office Action (no translation), Sep. 13, 2005.

TW, 90114960, Jun. 28, 2001, Molecular Staging, Inc., Instructions for Responding to May 16, 2005 Office Action with Issued Claims of US Patent No. 6,531,283 and Allowed Claims of U.S. Appl. No. 10/341,267, Jun. 30, 2005.

TW, 90114960, Jun. 28, 2001, Molecular Staging, Inc., Office Action, May 16, 2005.

AU, 2001271722, Jul. 2, 2001, Molecular Staging, Inc., Notice of Acceptance, Mar. 29, 2006.

AU, 2001271722, Jul. 2, 2001, Molecular Staging, Inc., Response to Examination Report, Mar. 17, 2006.

AU, 2001271722, Jul. 2, 2001, Molecular Staging, Inc., Examination Report, Jun. 17, 2005.

CA, 2411794, Jul. 2, 2001, Molecular Staging, Inc., Notice of Abandonment, Aug. 28, 2007.

CA, 2411794, Jul. 2, 2001, Molecular Staging, Inc., Notice of National Entry, Jan. 16, 2003.

DE, 1950759.9, Jul. 2, 2001, Molecular Staging, Inc.

EP, 01950759.9, Jul. 2, 2001, Molecular Staging, Inc., Decision to Grant, Sep. 6, 2007.

EP, 01950759.9, Jul. 2, 2001, Molecular Staging, Inc., Response to Communication under Rule 51(4), Aug. 17, 2007.

EP, 01950759.9, Jul. 2, 2001, Molecular Staging, Inc., Communications under Rule 51(4), Apr. 26, 2007.

EP, 01950759.9, Jul. 2, 2001, Molecular Staging, Inc., Response to Examination Report, Jul. 7, 2006.

EP, 01950759.9, Jul. 2, 2001, Molecular Staging, Inc., Response to Examination Report, Oct. 24, 2005.

EP, 01950759.9, Jul. 2, 2001, Molecular Staging, Inc., Examination Report, Jun. 16, 2005.

EP, 01950759.9, Jul. 2, 2001, Molecular Staging, Inc., European Search Report, Jul. 1, 2004.

JP, 2002-508032, Jul. 2, 2001, Molecular Staging, Inc., Application Open for Public Inspection, Jan. 29, 2004.

PCT/US01/20933, Jul. 2, 2001, Molecular Staging, Inc., Yale University, International Preliminary Examination Report, Dec. 30, 2002.

PCT/US01/20933, Jul. 2, 2001, Molecular Staging, Inc., Yale University, International Search Report, Jan. 10, 2002.

PCT/US02/15045, May 10, 2002, Molecular Staging, Inc., International Preliminary Examination Report, Oct. 26, 2004.

PCT/US02/15045, May 10, 2002, Molecular Staging, Inc., International Search Report, Apr. 10, 2003.

AU, 2002362874, Oct. 15, 2002, Molecular Staging, Inc., Examination Report, Jan. 8, 2007.

CA, 246933, Oct. 15, 2002, Molecular Staging, Inc., Notice of Abandonment, Dec. 10, 2007.

CA, 246933, Oct. 15, 2002, Molecular Staging, Inc., Notice of National Entry, Jun. 1, 2004.

EP, 02801776.2, Oct. 15, 2002, Molecular Staging, Inc., Response to Examination Report, Dec. 5, 2007.

EP, 02801776.2, Oct. 15, 2002, Molecular Staging, Inc., Examination Report, Aug. 7, 2007.

EP, 02801776.2, Oct. 15, 2002, Molecular Staging, Inc., European Search Report, Nov. 4, 2007.

EP, 02801776.2, Oct. 15, 2002, Molecular Staging, Inc., Letter Regarding European Search Report, Dec. 7, 2006.

EP, 02801776.2, Oct. 15, 2002, Molecular Staging, Inc., European Search Report, Nov. 7, 2006.

PCT/US02/33244, Oct. 15, 2002, Molecular Staging, Inc., International Preliminary Examination Report, Jul. 13, 2004.

PCT/US02/33244, Oct. 15, 2002, Molecular Staging, Inc., International Search Report, Apr. 29, 2004.

AU, 10240/97, Nov. 21, 1996, Yale University, Notice of Acceptance, Nov. 22, 1999.

AU, 10240/97, Nov. 21, 1996, Yale University, Response to Examination Report, Nov. 16, 1999.

AU, 10240/97, Nov. 21, 1996, Yale University, Examination Report, Apr. 30, 1999.

BE, 96940601.6, Nov. 21, 1996, Yale University, Notice of National Processing Completion, Apr. 20, 2001.

CH, 96940601.6, Nov. 21, 1996, Yale University.

DE, 826656, Nov. 21, 1996, Yale University, Patent Granted, Sep. 11, 2001.

DK, 96940601.6, Nov. 21, 1996, Yale University.

FR, 96940601.6, Nov. 21, 1996, Yale University.

GB, 96940601.6, Nov. 21, 1996, Yale University.

CA, 2236161, Nov. 21, 1996, Yale University, Notice of Allowance, Jun. 13, 2007.

CA, 2236161, Nov. 21, 1996, Yale University, Response to Examination Report, Oct. 4, 2006.

CA, 2236161, Nov. 21, 1996, Yale University, Examination Report, Apr. 4, 2006.

EP, 96940601.6, Nov. 21, 1996, Yale University, Decision to Grant, Jan. 25, 2001.

EP, 96940601.6, Nov. 21, 1996, Yale University, Response to Communication under Rule 51(4), Dec. 21, 1999.

EP, 96940601.6, Nov. 21, 1996, Yale University, Communication under Rule 51(4), Jul. 1, 1999.

JP, 9-519942, Nov. 21, 1996, Yale University, Letter from Foreign Associate re Notice of Allowance, May 30, 2007.

JP, 9-519942, Nov. 21, 1996, Yale University, Instructions for Responding to Jun. 27, 2006 Examination Report, Dec. 13, 2006.

JP, 9-519942, Nov. 21, 1996, Yale University, Examination Report, Jun. 27, 2006.

LU, 96940601.6, Nov. 21, 1996 Yale University.

MC, 96940601.6, Nov. 21, 1996, Yale University.

NL, 96940601.6, Nov. 21, 1996, Yale University.

PCT/US96/18812, Nov. 21, 1996, Yale University, International Preliminary Examination Report, Jan. 28, 1998.

PCT/US96/18812, Nov. 21, 1996, Yale University, International Search Report, Jun. 3, 1997.

PCT/US96/18812, Nov. 21, 1996, Yale University, Response to Written Opinion, Nov. 18, 1997.

PCT/US96/18812, Nov. 21, 1996, Yale University, Written Opinion, Aug. 21, 1997.

PCT/US96/18812, Nov. 21, 1996, Yale University, International Search Report, Nov. 21, 1995.

SE, 96940601.6, Nov. 21, 1996, Yale University.

PCT/US03/00678, Jan. 9, 2003, Molecular Staging, Inc., International Search Report, Aug. 14, 2003.

AU, 27819/00, Dec. 14, 1999, Molecular Staging, Inc., Deed of Letter.

AU, 27819/00, Dec. 14, 1999, Molecular Staging, Inc., Notice of Acceptance, May 12, 2005.

AU, 27819/00, Dec. 14, 1999, Molecular Staging, Inc., Response to Examination Report, Apr. 15, 2005.

AU, 27819/00, Dec. 14, 1999, Molecular Staging, Inc., Examination Report, Dec. 8, 2004.

AU, 27819/00, Dec. 14, 1999, Molecular Staging, Inc., Response to Examination Report, Nov. 30, 2004.

AU, 27819/00, Dec. 14, 1999, Molecular Staging, Inc., Examination Report, Oct. 14, 2004.

AU, 27819/00, Dec. 14, 1999, Molecular Staging, Inc., Response to Examination Report, Sep. 22, 2004.

AU, 27819/00, Dec. 14, 1999, Molecular Staging, Inc., Examination Report, Aug. 8, 2003.

CA, 2394800, Dec. 14, 1999, Molecular Staging, Inc., Notice of Abandonment, Feb. 11, 2008.

CA, 2394800, Dec. 14, 1999, Molecular Staging, Inc., Notice of Reinstatement, Jan. 5, 2005.

CA, 2394800, Dec. 14, 1999, Molecular Staging, Inc., Notice of Abandonment, Feb. 9, 2004.

CA, 2394800, Dec. 14, 1999, Molecular Staging, Inc., Notice of National Entry, Sep. 27, 2002.

EP, 99969209.8, Dec. 14, 1999, Molecular Staging, Inc., European Search Report, Feb. 21, 2003.

JP, 2000-588388, Dec. 14, 1999, Molecular Staging, Inc., Notice of Allowance, Jul. 22, 2008.

JP, 2000-588388, Dec. 14, 1999, Molecular Staging, Inc., Examination Report, Jul. 24, 2007.

PCT/AU99/01110, Dec. 14, 1999, Diatech Pty. Ltd., International Search Report, Jun. 22, 2000.

AU, 2003297891, Dec. 11, 2003, Qiagen GMBH.

CA, 2512196, Dec. 11, 2003, Qiagen GMGH, Notice of Abandonment, Feb. 8, 2008.

CA, 2512196, Dec. 11, 2003, Qiagen GMGH, Notice of National Entry, Oct. 3, 2005.

EP, 03796961.5, Dec. 11, 2003, Qiagen GMBH, Response to Examination Report, Oct. 26, 2007.

EP, 03796961.5, Dec. 11, 2003, Qiagen GMBH, Examination Report, Jun. 29, 2007.

EP, 03796961.5, Dec. 11, 2003, Qiagen GMBH, European Search Report, Jan. 16, 2007.

JP, 2004-565385, Dec. 11, 2003, Qiagen GMBH, Request for Examination, Nov. 22, 2006.

PCT/US03/39430, Dec. 11, 2003, Qiagen GMBH, International Search Report, Nov. 11, 2004.

AU, 2001268725, Jun. 27, 2001, Qiagen GMBH, Notice of Abandonment, Feb. 4, 2008.

AU, 2001268725, Jun. 27, 2001, Qiagen GMBH, Notice of Acceptance, Jul. 20, 2006.

AU, 2001268725, Jun. 27, 2001, Qiagen GMBH, Response to Examination Report, Jun. 23, 2006.

AU, 2001268725, Jun. 27, 2001, Qiagen GMBH, Examination Report, Jul. 18, 2005.

CA, 2410951, Jun. 27, 2001, Qiagen GMBH, Notice of Abandonment, Aug. 22, 2007.

CA, 2410951, Jun. 27, 2001, Qiagen GMBH, Notice of National Entry, Jan. 14, 2003.

DE, 01946712.5, Jun. 27, 2001, Qiagen GMBH.

EP, 01946712.5, Jun. 27, 2001, Molecular Staging, Inc., Decision to Grant, Sep. 21, 2006.

EP, 01946712.5, Jun. 27, 2001, Molecular Staging, Inc., Response to Communication under Rule 51(4), Aug. 18, 2006.

EP, 01946712.5, Jun. 27, 2001, Molecular Staging, Inc., Communication under Rule 51(4), Apr. 19, 2006.

EP, 01946712.5, Jun. 27, 2001, Molecular Staging, Inc., Response to Examination Report, Feb. 7, 2006.

EP, 01946712.5, Jun. 27, 2001, Molecular Staging, Inc., Observations by Third Parties, Jan. 23, 2006.

EP, 01946712.5, Jun. 27, 2001, Molecular Staging, Inc., Transmittal of Third Party Observations, Jan. 9, 2006.

EP, 01946712.5, Jun. 27, 2001, Molecular Staging, Inc., Observations by Third Parties, Dec. 28, 2005.

EP, 01946712.5, Jun. 27, 2001, Molecular Staging, Inc., Consultation by Phone, Dec. 15, 2005.

EP, 01946712.5, Jun. 27, 2001, Molecular Staging, Inc., Notification Concerning Date of Oral Proceedings, Dec. 6, 2005.

EP, 01946712.5, Jun. 27, 2001, Molecular Staging, Inc., Letter Dealing with Oral Proceedings, Nov. 29, 2005.

EP, 01946712.5, Jun. 27, 2001, Molecular Staging, Inc., Consultation by Phone, Nov. 16, 2005.

EP, 01946712.5, Jun. 27, 2001, Molecular Staging, Inc., Letter Dealing with Oral Proceedings, Oct. 31, 2005.

EP, 01946712.5, Jun. 27, 2001, Molecular Staging, Inc., Summons to attend Oral Proceedings, Jul. 1, 2005.

EP, 01946712.5, Jun. 27, 2001, Molecular Staging, Inc., Preparation for Oral Proceedings, Jun. 28, 2005.

EP, 01946712.5, Jun. 27, 2001, Molecular Staging, Inc., Response to Examination Report, Dec. 21, 2004.

EP, 01946712.5, Jun. 27, 2001, Molecular Staging, Inc., Examination Report, Nov. 11, 2004.

EP, 01946712.5, Jun. 27, 2001, Molecular Staging, Inc., Acknowledgment of Receipt of Third Party Observations, Oct. 29, 2004.

EP, 01946712.5, Jun. 27, 2001, Molecular Staging, Inc., Observations by Third Parties, Oct. 19, 2004.

EP, 01946712.5, Jun. 27, 2001, Molecular Staging, Inc., Response to Examination Report, Jul. 29, 2004.

EP, 01946712.5, Jun. 27, 2001, Molecular Staging, Inc., Examination Report, Mar. 19, 2004.

EP, 01946712.5, Jun. 27, 2001, Molecular Staging, Inc., Response to Examination Report, Jan. 30, 2004.

EP, 01946712.5, Jun. 27, 2001, Molecular Staging, Inc., Examination Report, Jul. 24, 2003.

FR, 01946712.5, Jun. 27, 2001, Molecular Staging, Inc.

GB, 01946712.5, Jun. 27, 2001, Molecular Staging, Inc.

IL, 153097, Jun. 27, 2001, Molecular Staging, Inc.

IT, 01946712.5, Jun. 27, 2001, Molecular Staging, Inc.

JP, 2002/506247, Jun. 27, 2001, Molecular Staging, Inc.

PCT/US01/20217, Jun. 27, 2001, Molecular Staging, Inc., International Preliminary Examination Report, Dec. 6, 2004.

PCT/US01/20217, Jun. 27, 2001, Molecular Staging, Inc., International Search Report, Apr. 3, 2003.

AU, 200253328, Jun. 12, 2000, Molecular Staging, Inc.

EPC, 938263.1, Jun. 12, 2000, Molecular Staging, Inc.

JP, 469290-19, Jun. 12, 2000, Molecular Staging, Inc.

PCT/US00/16130, Jun. 12, 2000, Molecular Staging, Inc., International Preliminary Examination Report, Dec. 28, 2004.

PCT/US00/16130, Jun. 12, 2000, Molecular Staging, Inc., International Search Report, Nov. 22, 2001.

AU, 2002/239809, Jan. 4, 2002, Molecular Staging, Inc.

CA, PCT/US02/00005, Jan. 4, 2002, Molecular Staging, Inc.

EPC, 2705674.6, Jan. 4, 2002, Molecular Staging, Inc.

PCT/US02/00005, Jan. 4, 2002, Molecular Staging, Inc., International Preliminary Examination Report, Jul. 5, 2003.

PCT/US02/00005, Jan. 4, 2002, Molecular Staging, Inc., International Search Report, May 22, 2003.

AU, 18040/01, Nov. 28, 2000, Molecular Staging, Inc.

CA, 2360342, Nov. 28, 2000, Molecular Staging, Inc.

EP, 00980827.0, Nov. 28, 2000, Molecular Staging, Inc., Response to Communication Pursuant to Rules 109 and 110 EPC, Oct. 17, 2001.

EP, 00980827.0, Nov. 28, 2000, Molecular Staging, Inc., Communication Pursuant to Rules 109 and 110 EPC, Sep. 13, 2001.

JP, 469290-68, Nov. 28, 2000, Molecular Staging, Inc.

PCT/US00/32370, Nov. 28, 2000, Molecular Staging, Inc., International Search Report, Jul. 11, 2002.

AU, 2001/251359, Apr. 5, 2001, Molecular Staging, Inc.

CA, 2405687, Apr. 5, 2001, Molecular Staging, Inc.

EPC, 1924731.1, Apr. 5, 2001, Molecular Staging, Inc.

JP, 2001-575244, Apr. 5, 2001, Molecular Staging, Inc.

PCT/US01/11151, Apr. 5, 2001, Molecular Staging, Inc., International Preliminary Examination Report, Oct. 15, 2004.

PCT/US01/11151, Apr. 5, 2001, Molecular Staging, Inc., International Search Report, Oct. 18, 2002.

PCT/US02/19443, Jun. 19, 2002, Molecular Staging, Inc., International Preliminary Examination Report, Feb. 16, 2006.

PCT/US02/19443, Jun. 19, 2002, Molecular Staging, Inc., International Search Report, Oct. 10, 2003.

PCT/US02/27097, Aug. 14, 2002, Molecular Staging, Inc., International Preliminary Examination Report, Oct. 12, 2004.

PCT/US02/27097, Aug. 14, 2002, Molecular Staging, Inc., International Search Report, Jan. 29, 2003.

EPC, 7118804.9, Oct. 18, 2007, Qiagen GMBH, European Search Report, Feb. 15, 2008.

AU, 97915/98, Oct. 8, 1998, Yale University, Issue Notification, Oct. 10, 2002.

AU, 97915/98, Oct. 18, 1998, Yale University, Notice of Acceptance, May 20, 2002.

AU, 97915/98, Oct. 8, 1998, Yale University, Response to Examination, Mar. 27, 2002.

AU, 97915/98, Oct. 8, 1998, Yale University, Examination Report, May 25, 2001.

CA, 2308004, Oct. 8, 1998, Yale University, Notice of Abandonment, Dec. 4, 2007.

CA, 2308004, Oct. 8, 1998, Yale University, Notice of Acceptance, Oct. 23, 2006.

CA, 2308004, Oct. 8, 1998, Yale University, Response to Examination, Dec. 23, 2004.

CA, 2308004, Oct. 8, 1998, Yale University, Examination Report, Jun. 30, 2004.

EP, 98952147.1, Oct. 8, 1998, Yale University, Decision to Grant, Dec. 6, 2007.

EP, 98952147.1, Oct. 8, 1998, Yale University, Response to Communication under Rule 51(4), Oct. 5, 2007.

EP, 98952147.1, Oct. 8, 1998, Yale University, Communication under Rule 51(4), Jun. 6, 2007.

EP, 98952147.1, Oct. 8, 1998, Yale University, Response to Examination Report, May 15, 2007.

EP, 98952147.1, Oct. 8, 1998, Yale University, Consultation by Phone, Apr. 16, 2007.

EP, 98952147.1, Oct. 8, 1998, Yale University, Response to Examination Report, Mar. 13, 2007.

EP, 98952147.1, Oct. 8, 1998, Yale University, Consultation by Phone, Dec. 29, 2006.

EP, 98952147.1, Oct. 8, 1998, Yale University, Response to Examination Report, Mar. 6, 2006.

EP, 98952147.1, Oct. 8, 1998, Yale University, Examination Report, Sep. 21, 2005.

JP, 2000-515033, Oct. 8, 1998, Yale University, Notice of Allowance, Feb. 3, 2009.

JP, 2000-515033, Oct. 8, 1998, Yale University, Argument and an Amendment to the outstanding Official Action, Dec. 22, 2008.

JP, 2000-515033, Oct. 8, 1998, Yale University, Notice of Rejection, Dec. 2, 2008.

JP, 2000-515033, Oct. 8, 1998, Yale University, Report Concerning Reconsideration by Examiner before Appeal, Oct. 2, 2007.

JP, 2000-515033, Oct. 8, 1998, Yale University, Letter from Foreign Associate re Filing Amendment and Response to Official Action, Mar. 24, 2006.

JP, 2000-515033, Oct. 8, 1998, Yale University, Instructions to Foreign Associate re Sep. 2, 2005, Final Rejection, Feb. 8, 2006.

JP, 2000-515033, Oct. 8, 1998, Yale University, Instructions to Foreign Associate re Sep. 2, 2005 Final Rejection, Dec. 2, 2005.

JP, 2000-515033, Oct. 8, 1998, Yale University, Final Rejection, Sep. 2, 2005.

JP, 2000-515033, Oct. 8, 1998, Yale University, Response to Examination (no translation), Nov. 11, 2004.

JP, 2000-515033, Oct. 8, 1998, Yale University, Instructions to Foreign Associate re May 7, 2004 Examination Report, Aug. 9, 2004.

JP, 2000-515033, Oct. 8, 1998, Yale University, Examination Report, May 7, 2004.

PCT/US98/21177, Oct. 8, 1998, Yale University, International Preliminary Examination Report, Oct. 12, 1999.

PCT/US98/21177, Oct. 8, 1998, Yale University, International Search Report, Apr. 15, 1999.

EP, 99935725.4, Jul. 20, 1999, Yale University, Examination Report, Aug. 13, 2003.

PCT/US99/16373, Jul. 20, 1999, Yale University, International Search Report, Nov. 9, 2000.

Referenced By

Document Number	Assignee	Inventors	Issue/Pub Date
US7955795	QIAGEN GmbH	Gyanendra Kumar	Jun 2011
US8043834	Qiagen GmbH	Patricio Abarza et al.	Oct 2011
US8309303	QIAGEN GmbH	Christian Korfhage et al.	Nov 2012

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