Hexenoic acid derivatives, processes for the preparation thereof, pharmaceutical compositions comprising them, and therapeutic applications thereof

Share
Save

Share On Facebook Share On Twitter Share By Email
Save Item
Add to
my lists

Filing Information

  • Patent Number: US7632846
  • Application Number: US11579361
  • Filing date: 04/06/2005
  • PCT 371 date: 11/02/2006
  • Issue date: 12/15/2009
  • Prior Publication Data:
  • Predicted expiration date: 01/19/2026
  • Patent term adjustment: 288
Explore Your Innovation Network™ for an introduction to:

Innovation Network Your First Name:
 Last Name:
  
Already a member? Sign In
  • U.S. Classifications: 514/311  · 549/80  · 514/571  · 546/152  · 549/79  · 514/433  · 549/81  · 549/49  · 549/58  · 562/465  · 514/438  ·
  • International Classifications: A61K31381 · A61K3147 · A61K31192 · C07D33328 · C07D21504 · C07D33352 · C07C5911 · C07C59115 ·
  • PCT Application Number: WO20PCTEP2005003606 - 04/06/2005
  • PCT Publication Number: WO2005105724 - 11/10/2005
  • Foreign Priority: FR0404713 - 05/03/2004 ·
7 Claims, No Drawings


Abstract

Compounds of the formula (I): in which R, R1, R2 and R3 are as defined in the description, the use thereof for the treatment of dyslipidaemia, atherosclerosis and diabetes, pharmaceutical compositions comprising them, and processes for the preparation of these compounds.

References Cited

U.S. Patent Documents

Document NumberAssigneesInventorsIssue/Pub Date
US4335249* Rohm and Haas Company Johnson et al. Jun 1982
US4562287 Scharper S.p.A. per l'Industria Farmaceutica Del Vecchui et al. Dec 1985
US7465752* Merck Patent GmbH Zeiller et al. Dec 2008
* cited by examiner

Referenced By

The current document is not referenced by other documents.

Patent Family

The current document is not in a family.

Read Patent

Read patent

View Drawings


Independent Claims | See all claims (7)

  1. 1. A compound, which is 2-(4′-methoxybiphenyl-4-yloxy)hex-5-enoic acid; 2-(4′-fluorobiphenyl-4-yloxy)hex-5-enoic acid; 2-(4′-phenoxyphenoxy)hex-5-enoic acid; 4-cyclohex-1-enyl-2-[4-(2-methylthiazol-4-yl)phenoxy]butanoic acid; 4-cyclohex-1-enyl-2-[4-(trifluoromethyl)phenoxy]butanoic acid; 4-cyclohex-1-enyl-2-(4′-methoxy-1,1′-biphenyl-4-yloxy)butanoic acid; 2-[4-(5-chlorothiophen-2-yl)phenoxy]-4-cyclohex-1-enylbutanoic acid; 2-(4-chlorophenoxy)-4-cyclohex-1-enylbutanoic acid; 2-(4-benzo[b]thiophen-2-ylphenoxy)-4-cyclohex-1-enylbutanoic acid; 2-(4-benzo[b]thiophen-3-ylphenoxy)hex-5-enoic acid; 2-(3′-fluorobiphenyl-4-yloxy)hex-5-enoic acid; 2-(4-trifluoromethylphenoxy)hex-5-enoic acid; 2-[4-(2-methylthiazol-4-yl)phenoxy]hex-5-enoic acid; 2-(2′,5′-dimethylbiphenyl-4-yloxy)hex-5-enoic acid; 2-(4′-trifluoromethoxybiphenyl-4-yloxy)hex-5-enoic acid; 2-(4′-chlorobiphenyl-4-yloxy)hex-5-enoic acid; or 2-[3-(quinolin-2-ylmethoxy)phenoxy]hex-5-enoic acid, or an optical isomers thereof, or a pharmaceutically acceptable salt thereof.