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US7645925: Tobacco products with increased nicotine

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Filing Information

Inventor(s) Mark A. Conkling · Wen Song · Nandini Mendu ·
Assignee(s) North Carolina State University ·
Attorney/Agent(s) Myers Bigel Sibley & Sajovec, P.A. ·
Primary Examiner Russell Kallis ·
Application Number US11416574
Filing date 05/03/2006
Issue date 01/12/2010
Prior Publication Data
Predicted expiration date 02/10/2018
U.S. Classifications 800/317.3  · 536/231  · 800/298  · 435/320.1  · 435/419  · 800/293  · 536/232  · 536/236  · 131/360  · 131/366  · 800/287  ·
International Classifications A01H500  · A01H510  · C12N1529  · C12N1554  · C12N1582  ·
Kind CodeB2
Related U.S. Application DataCROSS REFERENCE TO RELATED APPLICATION
This application is a continuation application of, and claims priority to, U.S. application Ser. No. 10/356,076, filed Jan. 31, 2003, and issued as U.S. Pat. No. 7,304,220 on Dec. 4, 2007, which is a continuation application of U.S. application Ser. No. 09/021,286, filed Feb. 10, 1998 and issued as U.S. Pat. No. 6,586,661 on Jul. 1, 2003 and which claims the benefit of U.S. Provisional Application No. 60/049,471, filed Jun. 12, 1997. The entire contents of each of these applications is incorporated by reference herein.
10 Claims, 7 Drawings


Abstract

DNA encoding a plant quinolate phosphoribosyl transferase (QPRTase) enzyme, and constructs comprising such DNA are provided. Methods of altering quinolate phosphoribosyl transferase expression are provided.

Independent Claims | See all claims (10)

  1. 1. A tobacco product produced from a transgenic tobacco plant of the genus Nicoriana having increased quinolate phosphoribosyl transferase (QPRTase) production relative to a non-transformed control plant, said transgenic plant comprising transgenic plant cells comprising: an exogenous nucleic acid construct comprising, in the 5′ to 3′ direction, a promoter operable in said plant cell and a heterologous nucleic acid operably associated with said promoter; said plant exhibiting increased QPRTase production compared to a non-transformed control plant and; said heterologous nucleic acid comprising a nucleotide sequence selected from the group consisting of: (a) the nucleotide sequence of SEQ ID NO:1; (b) a nucleotide sequence that encodes an enzyme having the amino acid sequence of SEQ ID NO:2; (c) a nucleotide sequence having at least 95% identity with the nucleotide sequence of (a) or (b) above and that encodes a plant quinolate phosphoribosyl transferase; and (d) a nucleotide sequence that differs from the nucleotide sequence of (a) or (b) above due to the degeneracy of the genetic code and that encodes a plant quinolate phosphoribosyl transferase enzyme.
  2. 2. A tobacco product produced from a transgenic tobacco plant of the genus Nicotiana having an increased level of nicotine in leaves of said plant, wherein said transgenic plant comprises transgenic plant cells comprising: an exogenous nucleic acid construct comprising, in the 5′ to 3′ direction, a promoter operable in said plant cell and a heterologous nucleic acid operably associated with said promoter; said plant exhibiting increased nicotine production compared to a non-transformed control plant and; said heterologous nucleic acid comprising a nucleotide sequence selected from the group consisting of: (a) the nucleotide sequence of SEQ ID NO:1; (b) a nucleotide sequence that encodes an enzyme having the amino acid sequence of SEQ ID NO:2; (c) a nucleotide sequence having at least 95% identity with the nucleotide sequence of (a) or (b) above and that encodes a plant quinolate phosphoribosyl transferase; and (d) a nucleotide sequence that differs from the nucleotide sequence of (a) or (b) above due to the degeneracy of the genetic code and that encodes a plant quinolate phosphoribosyl transferase enzyme.
  3. 3. A tobacco product comprising a tobacco cell comprising an exogenous nucleotide sequence encoding a plant quinolate phosphoribosyl transferase enzyme, wherein the exogenous nucleotide sequence is selected from the group consisting of: a) the nucleotide sequence of SEQ ID NO:1; b) a nucleotide sequence that encodes the amino acid sequence of SEQ ID NO:2; c) a nucleotide sequence having at least 95% identity with the nucleotide sequence of (a) or (b) above and that encodes a plant quinolate phosphoribosyl transferase; and d) a nucleotide sequence that differs from the nucleotide sequence of (a) or (b) above due to the degeneracy of the genetic code, and that encodes a plant quinolate phosphoribosyl transferase.

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