Amphiphilic imidazolinium derivatives
U.S. Patent US5736395 | Filed: 05/19/1997 | Issued: 04/07/1998
Amphiphiles containing an imidazdinium ring system are provided that are non-toxic to the host mammal. The amphiphiles are used to produce liposomes useful as carriers for delivering macromolecules...
Assignee(s): Megabios Corporation | Inventor(s): Timothy D. Heath + 1 | Agent(s): McDonnell Boehnen Hulbert & Berghoff | Examiner(s): Floyd D. Higel |
Method for culturing t lineage precursor cells under conditions of high oxygen concentration
U.S. Patent US5792655 | Filed: 09/11/1995 | Issued: 08/11/1998
The present invention provides culture methods of T lineage precursor cells comprising a step of culturing the T lineage precursor cells under a condition that a dissolved oxygen concentration in t...
Assignee(s): Japan Tobacco, Inc. | Inventor(s): Yoshihiro Watanabe | Agent(s): Birch, Stewart, Kolasch & Birch, LLP | Examiner(s): Marian C. Knode |
Method for in vitro proliferation of dendritic cell precursors and their use to produce immunogens
U.S. Patent US5994126 | Filed: 06/17/1994 | Issued: 11/30/1999
A method for producing proliferating cultures of dendritic cell precursors is provided. Also provided is a method for producing mature dendritic cells in culture from the proliferating dendritic ce...
Assignee(s): The Rockefeller University | Inventor(s): Ralph M. Steinman + 2 | Agent(s): Morgan & Finnegan, L.L.P. | Examiner(s): Lankford, Jr.; Leon B. |
Monoclonal antibodies to ceftiofur
U.S. Patent US5908781 | Filed: 12/10/1996 | Issued: 06/01/1999
Hybridoma cell lines have been generated which produce and secrete monoclonal antibodies which selectively bind to the ceftiofur. These hybridomas may be obtained by using as an immunization agent ...
Assignee(s): The United States of America as represented by the Secretary of Agriculture | Inventor(s): Larry H. Stanker + 3 | Agent(s): Randall E. Deck | Examiner(s): Lila Feisee |
Monoclonal antibody to human mx protein mxa
U.S. Patent US6180102 | Filed: 10/02/1998 | Issued: 01/30/2001
This invention provides a monoclonal antibody which recognizes an epitope corresponding to amino acids 10 to 220, amino acids 221 to 297, or amino acids 469 to 662, counting from the N-terminus of ...
Assignee(s): Kyowa Hakko Kogyo Co., Ltd. + 1 | Inventor(s): Nobuo Hanai + 4 | Agent(s): Nixon & Vanderhye P.C. | Examiner(s): Marianne P. Allen |
Anti-fas ligand antibody and assay method using the anti-fas ligand antibody
U.S. Patent US6114507 | Filed: 05/17/1996 | Issued: 09/05/2000
An anti-Fas ligand antibody capable of suppressing Fas ligand-induced apoptosis to a high degree, especially humanized antibodies having less antigenecity to human, and a method for assaying the Fa...
Assignee(s): Mochida Pharmaceutical Co., Ltd. + 1 | Inventor(s): Kamon Shirakawa + 4 | Agent(s): Birch, Stewart, Kolasch & Birch, LLP | Examiner(s): Jeffrey Stucker |
Antithrombotic agent and humanized anti-von willebrand factor monoclonal antibody
U.S. Patent US6228360 | Filed: 08/19/1998 | Issued: 05/08/2001
Anti-thrombotic agents containing humanized antibodies which bind to von Willebrand factor.
Assignee(s): Ajinomoto Co., Inc. | Inventor(s): Man Sung Co + 1 | Agent(s): Oblon, Spivak, McClelland, Maier & Neustadt, P.C. | Examiner(s): Phillip Gambel |
Ip-10/mig receptor designated cxcr3, antibodies, nucleic acids, and methods of use therefor
U.S. Patent US6184358 | Filed: 03/31/1997 | Issued: 02/06/2001
The present invention relates to proteins or polypeptides, referred to herein as isolated and/or recombinant mammalian (e.g., human) IP-10/Mig receptor proteins designated CXC Chemokine Receptor 3 ...
Assignee(s): Millennium Pharmaceuticals, Inc. + 1 | Inventor(s): Marcel Loetscher + 3 | Agent(s): Hamilton, Brook, Smith & Reynolds, P.C. | Examiner(s): Prema Mertz |
Humanized antibodies reactive with l-selectin
U.S. Patent US6210671 | Filed: 12/27/1995 | Issued: 04/03/2001
Humanized immunoglobulins specifically reactive with L-selectin are prepared employing recombinant DNA technology for use in e.g., treatment of inflammatory disorders.
Assignee(s): Protein Design Labs, Inc. | Inventor(s): Man Sung Co | Agent(s): Townsend & Townsend & Crew | Examiner(s): Phillip Gambel |
Transgenic non-human animals for producing heterologous antibodies
U.S. Patent US6300129 | Filed: 12/02/1996 | Issued: 10/09/2001
The invention relates to transgenic non-human animals capable of producing heterologous antibodies and methods for producing human sequence antibodies which bind to human antigens with substantial ...
Assignee(s): GenPharm International | Inventor(s): Nils Lonberg + 1 | Agent(s): Townsend & Townsend & Crew | Examiner(s): Karen M. Hauda |
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